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Biomedical subjects

E T Jacob

Publications and source records attributed to E T Jacob.

At least 37 records · Page 2Linked to original sources
PubMed1981

Alleviation of experimental ischemic acute renal failure by dimethyl sulfoxide.

Acute, ischemic renal failure was induced in rats by clamping of the renal vessels for 1 h. Following the termination of the ischemic period 5 g/kg of dimethyl sulfoxide (DMSO) were administered intravenously as a 20% solution in saline. Control animals received normal saline. There were not deaths among the DMSO-treated animals. Urine flow began within 15 min of DMSO infusion. 24 h after the experiment the mean blood urea was 73 +/- (SEM) 14 mg/100 ml (n = 29). All the control rats died during the week following the experiment. The mean blood urea at 24 h was 276 +/- 18 mg/100 ml (n = 20). In 10 additional animals perfusion of the kidney with DMSO prior to the closure of renal vessels protected the organ from ischemic damage. These experiments have a bearing on the therapeutic approach to ischemic renal failure in man, and on preservation methods of donor kidneys for transplantation.

Acute Kidney Injury↗
PubMed1979

Angiotensin-converting enzyme inhibitor (SQ 20881) in the diagnosis of renovascular hypertension.

SQ 20881, an angiotensin-converting enzyme inhibitor, was given to 12 patients with renovascular hypertension and to 1 patient with unilateral parenchymatous renal disease in order to evaluate the role of renin-angiotensin systems in their hypertension. Plasma renin activity (PRA) and aldosterone were assayed in systemic blood before and after the injection of SQ 20881. In 5 patients PRA was also measured separately in each renal vein. Blood pressure decreased, PRA increased, and aldosterone level decreased in the 12 renin-dependent patients. When PRA was sampled separately from each renal vein, the increase was larger on the side of the affected kidney. Four patients with a positive test underwent corrective surgery, and in all blood pressure became normal. SQ 20881 is a useful agent in evaluating the contribution of renin in patients with hypertension.

Adolescent↗
PubMed1979

Renal transplantation in the amyloidosis of familial Mediterranean fever. Experience in ten cases.

Ten patients with familial Mediterranean fever (FMF) and histologically confirmed amyloidosis received cadaver kidney transplants for treatment of terminal renal disease. Colchicine, 1 mg daily, was included in the routine postoperative regimen from 1974 for amyloidotic patients. Graft and patient survival were compared with ten nonamyloidotic recipients of renal grafts matched for age, sex, type of allograft, and HLA compatibility. In the FMF group, five of ten grafts have survived from 20 to 64 months; in the control group, six of ten. While only recipients with functioning grafts survived in the FMF group, patient survival in the control group is eight of ten after one year. In all five FMF survivors, graft function is satisfactory, proteinuria is absent, and blood creatinine levels are normal. Amyloid involvement of an allograft was documented 16 months after transplantation in the only patient whose maintenance colchicine dosage had been reduced to 0.5 mg daily.

Adult↗
PubMed1977

Dacron arterio-venous interposition graft: an access to circulation in patients on chronic hemodialysis.

In a small percentage of cases, conventional a-v fistulae of the Brescia-Cimino type fail to provide long-term access facilities for chronic hemodialysis. When homologous venous interposition grafts are not available, the surgeon is forced to seek foreign interposition material. In three instances woven dacron arterio-venous interposition grafts were successfully constructed in the thigh, and uneventful hemodialysis was accomplished in all 3 patients.

Arteriovenous Shunt, Surgical↗
PubMed1977

Acute diaphragmatic hernia caused by blunt trauma.

Traumatic diaphragmatic hernia is being more frequently diagnosed in the acute phase because of a higher degree of alertness. Over a period of eight years the authors treated 16 patients. Associated injuries were present in eight cases and were responsible for the two deaths. The chest roentgenogram was diagnostic in most cases, but serial films and contrast examinations eventually were necessary. In order to attain a low morbidity and mortality rate, early surgery is recommended.

Accidents, Traffic↗
PubMed1976

Total anorectal reconstruction following congenital anorectal anomaly: report of a case.

Following several unsuccessful postnatal attempts at anoplasty to correct anal atresia with a rectovaginal fistula, the patient, 20 years later, underwent an anorectal sphincteric construction using a gracilis-muscle transplant. The five-stage procedure, which extended over a period of two years, resulted in highly satisfactory continence and full social rehabilitation of the patient. The continence achieved in this case seems to be in contradiction to some of the accepted concepts of the mechanisms of continence.

Adult↗