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Biomedical subjects

E Straus

Publications and source records attributed to E Straus.

67 records · Page 4Linked to original sources
PubMed1975

Effect of secretin on release of heterogeneous forms of gastrin.

The effect of an intravenous injection of secretin on plasma gastrin concentration is shown to be dependent upon the relative concentration of the major forms of immunoreactive gastrin present in the plasma at the time of injection. Secretin suppressed gastrin secretion in the fasting state in patients in whose plasma heptadecapeptide and big gastrins predominated and did not suppress when big big gastrin comprised more than 90% of plasma gastrin immunoreactivity. The post-secretin decrease in plasma gastrin was due entirely to the disappearance of the smaller, more rapidly degraded forms. Food-stimulated gastrin response was suppressed by secretin for the initial 40 minutes after a test meal but was greater than usual from 40 to 120 minutes.

Anemia, Pernicious↗
PubMed1975

Migration of peripheral leukocytes in the presence of carcinoembryonic antigen. Studies in patients with chronic inflammatory diseases of the intestine and carcinoma of the colon and pancreas (32568).

The leukocyte migration technique was employed to study in vitro cell-mediated immune responses to purified CEA in patients with Crohn's disease and active ulcerative colitis and in those with colonic and pancreatic carcinoma. No significant inhibition of leukocyte migration was demonstrated by CEA, with the exception of one patient with pancreatic carcinoma. Thus, with the leukocyte migration technique, no consistent in vitro cell-mediated immunity to CEA was demonstrated supporting the hypothesis that CEA is not the antigen toward which cell-mediated host response phenomena are directed.

Adenocarcinoma↗
PubMedDate not supplied

Ontogeny of immunoreactive CCK and VIP in pig brain and gut.

The concentrations and hormonal forms of CCK and VIP have been determined in extracts of the brain and duodenum of the developing and adult pig. In methanol extracts of the brain cortex, the single hormone form, CCK8, increased from 130 +/- 20 (Mean +/- SEM) pmol/g at birth to an adult level of 300 +/- 50 pmol/g. In acid extracts of brain, the predominant immunoreactive form had N-terminal immunoreactivity and increased from 240 +/- 20 pmol/g at birth to an adult level 490 +/- 30 pmol/g; the C-terminal immunoreactivity was about 10-fold lower. The concentrations and hormonal forms of immunoreactive CCK in duodenal extracts did not appear to be age-related. C-terminal immunoreactivity in methanol extracts averaged 140 +/- 20 pmol/g and in acid extracts 240 +/- 60 pmol/g. The concentration of N-terminal immunoreactivity in acid extracts averaged 490 +/- 70 pmol/g. The VIP concentrations in acid extracts of the brain cortex was 13.5 +/- 2 pmol/g at birth and rose gradually to 30 +/- 9 pmol/g in the adult; in duodenal extracts it was 240 +/- 18 pmol/g at birth and 195 +/- 38 pmol/g in the adult. These results are in marked contrast with the ontogeny of these hormones in the rat in which brain concentrations of CCK and VIP in the neonate are less than 10% of adult levels and in which there are age-related changes in the content of these hormones in the duodenum as well.

Aging↗