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Biomedical subjects

E Straub

Publications and source records attributed to E Straub.

At least 37 records · Page 2Linked to original sources
PubMed1977

Renal sonography in pediatric patients. A comparative study between sonography and urography.

Renal sonograms of 260 children were compared with the corresponding excretory urograms. Since each kidney was evaluated separately 520 sonographic and urographic findings could be compared. The study is based on single investigations only, serial investigations were not included. 326 kidneys could be classified as being normal, primarily on the basis of the urogram. By sonography only 10 out of these 326 were misinterpretated as being pathological, 2 by urography. 194 kidneys could be classified as being pathological either by urography or- if necess -by other methods. In 16 out of these 194 no evidence for a pathological process could be found in the sonogram (7 cases of destructive pyelonephritis, 3 cases of double kidneys, 2 cases of slight obstruction of urine flow, 2 cases of small kidneys, 2 cases of ureteral buds), in 10 cases no evidence was seen in the urogram (6 cases of glomerulonephritis, 2 cases of polycystic kidneys, 1 case of preversial ureteral buds), in 10 cases no evidence was seen in the urogram (6 cases of glomerulonephritis, 2 cases of polycystic kidneys, 1 case of prevesical ureterolith, 1 case of ureteral bud). In 2 cases pathological alterations of the kidney was found by both methods, however, the diagnosis differed. Nonfunctioning kidneys were found in 15 cases. In all of these the sonogram provided important complementary information. Our results show 1) that by a systematic application of sonography the early diagnosis of urinary tract malformations can be improved 2) that renal sonography provides the basis for a stricter application of excretory urography and 3) that by the combination of both methods the diagnosis of renal diseases can be improved.

Adolescent↗
PubMed1977

Influence of L-thyroxine upon enzymatic activity in the renal tubular epithelium of the rat under normal conditions and in mercury-induced lesions. I. Histochemical studies of alkaline phosphatase, acid phosphatase, adenosine- tri-phosphatase and leucine-aminopeptidase.

HgC12-induced renal tubular lesions in the rat present histochemically with a transitory decrease of alkaline phosphatase, adenosinetriphosphatase (ATPase), and leucine-aminopeptidase activity. The toxic alterations of enzyme activity were more pronounced in the pars recta of the proximal tubule and in the loop of Henle, as compared with the tubulus contortus I. L-thyroxine treatment leads to an accelerated reversal of that enzymatic defect, followinga characteristic pattern, and to a differentiating increase of acid phosphatase and ATPase activity in certain parts of the normal renal tubule. The observations are discussed with reference to the specific mode of action of sublimate and l-thyroxine upon the tubular enzymes and to the well-known metabolic and functional influences of thyroid hormone on the kidney.

Acid Phosphatase↗
PubMed1977

Influence of L-thyroxine upon enzymatic activity in the renal tubular epithelium of the rat under normal conditions and mercury-induced lesions. II. Histochemical studies of lactate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, unspecific esterase, and glucose-6-phosphate dehydrogenase.

Mercury-induced renal tubular lesions in the rat present histochemically with a decrease of succinate dehydrogenase (SDH), malate dehydrogenase (MDH), glucose-6-phosphate dehydrogenase (G-6-PD), and unspecific esterase (UE), but with an increase of lactate dehydrogenase (LDH), indicating a drop of energy supply as well as a switch from oxidative to glycolytic energy production. L-thyroxine has the same effect on SDH, G-6-PD, and LDH, but an inverse effect on MDH and UE, pointing to stimulation of gluconeogenesis. However, administration of L-thyroxine to animals which have been submitted to sublimate intoxication even further decreases the MDH and UE activity while raising or partly restoring the activity of LDH, SDH, and G-6-PD. This observation is interpreted as an attempt of the damaged epithelial cell, as the gluconeogenesis ceases, to gain relatively more energy supply for the benefit of the vitally indispensable tubular Na+ reabsorption.

Acute Kidney Injury↗
PubMed1977

Nephrotic syndrome of childhood and disorder of T cell function.

In thirty-two patients with nephrotic syndrome (NS) phytohemagglutinin (PHA)-induced lymphocyte proliferation was studied at various stages of the disease. We demonstrated that lymphocyte transformation during acute exacerbation is markedly decreased, especially if cells are cultured in patient serum. During treatment with steroids PHA-stimulation improves. During full remission all patients showed their maximal lymphocyte stimulation. On the basis of these results and reports from the literature we postulate that patients with the NS have a T cell clone which inhibits the transformation capacity of the remaining lymphocytes through production of a heat stable serum factor. The same or a second factor produced by these lymphocytes could at the same time exert a toxic effect on the glomerular basement membrane.

Acute Disease↗
PubMed1977

[Vesicorenal reflux (author's transl)].

Antireflux procedures show high efficiency and relatively few technical complications. A tabulated comparison between the intravesical procedure (Politano-Leadbetter) and the extravesical procedure (Lich-Grégoir) reveals an overall success rate of 80%. To simplify the nomenclature, the term primary refluxing ureter is suggested for cases with a freely draining IVP and primary obstructive ureter for a dye collumnating dilated ureter. The indication for antirefluxplasty is divided into urgent cases and those with secondary priority, with immunologic tests providing helpful criteria.

Child↗
PubMed1976

Effects of L-thyroxine in acute renal failure.

Eight pediatric patients presenting with acute renal failure (shock kidney, anuria continuing for three to five days) were treated with L-thyroxine (p.o. 5-6 mug per kg per day). Dialysis was not used. Diuresis started within 34 to 46 hours. Serum levels of urea and creatinine normalized within a very short time. The results are discussed on the basis of a new hypothesis concerning the RPF- and GFR-raising action of thyroid hormone in the normal situation and in acute renal failure.

Acute Kidney Injury↗
PubMed1976

[Pyelonephritis in patients with congenital malformations of the urinary tract after corrective operation and under antibiotic therapy (author's transl)].

398 (otherwise unselected) children with certain types of congenital urinary tract malformation were followed up for a period of not less than three years for evaluation of the infection rate after surgical correction (the latter performed in 1968 to 1972). During a six month course post op., all patients received appropriate antibacterial drugs, thereafter cessation of medical treatment depending upon normal findings in urinalysis. The over-all cure rate was 77% after six months, 85% after twelve months, 95% after two years and 97% after three years. No recurrence of urinary tract infection was observed three years after surgery of in frapelvic ureteral stenosis/hydronephrosis (n=86; Anderson-Hynes procedure) in 100%; of distal ureteral stenosis/megaureter (n=76; Politano-Leadbetter or occasionally Boari approach) in 92%; and of primary reflux (n=236; Lich-Grégoir technique) in 98%. The incidence of infectious relapse following any normal cytological and bacteriological control was 1% resp. 7% resp. 2%, with an average of 3% for all three groups.

Adolescent↗
PubMed1976

[Leptospirosis epidemic (L. grippothyphosa) in the Mainz area, concerning the pediatric age group (author's transl)].

31 children, presenting with rather uncharacteristic symptoms of an infectious disease and being referred to this clinic mostly because of lymphadenitis of the neck (81%) and/or signs of meningitis (45%), were seen within a period of only eight weeks and proved to suffer from Leptospirosis (L. grippotyphosa). The majority of the patients belonged to the age group of one to six years and lived in rural environs. Our observation is considered to relate to a Leptospirosis epidemic and suggests, as opposed to the general acceptance, a much higher incidence of Leptospirosis in this country and, moreover, in children.

Ampicillin↗
PubMed1975

[Influence of L-thyroxine upon the ratio between protein-bound SH- and S-S-groups (author's transl)].

In normal rats and in rats with mercury-induced tubular lesions without or with successive L-thyroxine treatment, the number of SH-groups and the total of SH- and S-S-groups in different segments of the nephron were calculated over a period of time by means of a photometric assay. The quantity of SH-groups was increased by low doses of sublimate but reduced by exogenous L-thyroxine, the whole of SH- and S-S-groups summing up to a constant quantity throughout. (Following application of high doses of sublimate, a loss of SH- as well as S-S-groups was observed, due to cellular destruction.) Connection and splitting of S-S-bridges, respectively, corresponded to changes in certain parameters of cell function, for instance resorptive capacity. A hypothesis is proposed stating that a fundamental effect of thyroid hormone is exerted by a biochemical action upon the ration between SH- and S-S-groups, permeability of the cellular and mitochondrial membranes being raised when the numerical proportion of S-S-bonds is high. Stimulation of enzymatic activity and metabolic processes would therefore result adaptively from the augmentation of substrate supply within the cell organells.

Animals↗
PubMed1975

[99mTc-iron complex for demonstrating reflux without the use of a catheter (author's transl)].

99mTc-iron complex was used in 35 patients (20 adults and 15 children) in an investigation into ureteric reflux without using a catheter. The results were compared with the findings on micturating cysto-urethrography. Agreement in the findings was observed in 56 of the 69 kidneys examined. In only four kidneys, showing reflux radiologically, was this not observed on the isotope examination; in view of the low radiation dose, the catheter-free isotope method can be recommended as the most suitable investigation. The need for serial investigations or contrast allergies are important indications for using this method. The relatively high frequency with which reflux shown by the isotope method could not be confirmed radiologically (nine kidneys) indicates that the isotope is more sensitive than the radiological investigation.

Adolescent↗
PubMed1975

[Thyroxine treatment in acute renal failure (author's transl)].

8 patients suffering from acute renal failure (shock kidney) with anuria extending over 3 to 5 days, were treated with L-thyroxine for 5 to 9 days (5-6 mug per kg body weight per day orally). Diuresis was restored within 34 to 46 hrs. Plasma levels of urea and creatinine decreased earlier and much more rapidly to normal than was to be expected from the natural history of the disease, indicating the prompt and extensive increase of glomerular filtration rate. Polyuria seemed less pronounced and also shortened as compared with the ordinary course of that form of sudden renal insufficiency. Obviously, the well-known diuretic response in the normal individual to high doses of thyroid hormones in not a factor in the induction of diuresis in acute renal failure. The tendency with L-thyroxine treatment to dilate the preglomerular arterial vessel is considered a consequence of the stimulation of sodium reabsorption in the upper nephron. High values of RPF and GFR, regularly observed in hyperthyroidism or after L-thyroxine administration, do not depend on any augmentation of cardiac output or on arterial hypertension, since such symptoms were missed in our patients and, in our view, such an interpretation is excluded by the very existence of the so-called autoregulation of the kidney which leaves RPF (and therefore GFR) independent of systemic blood pressure. The same intrarenal feed-back mechanism, normally adapting the glomerular blood supply to the resorptive capacity of the proximal-tubular epithelium (mediation via the juxta-glomerular apparatus), is responsible for the GFR- and RPF-raising effect of exogenous L-thyroxine in the intact kidney as well as in acute renal failure: both sodium reabsorption and sodium filtration are accelerated.--The special conditions under which L-thyroxine interferes with the pathogenetic process of acute renal failure, the latter being characterised by the critical insufficiency of tubular sodium reabsorption and therefore by preglomerular arterial constriction, is discussed on the basis of a new hypothesis concerning the thyrogenic nephrotropic effects in general.

Acute Kidney Injury↗