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Biomedical subjects

E Stoupel

Publications and source records attributed to E Stoupel.

At least 37 records · Page 2Linked to original sources

Ventricular fibrillation secondary to ergotamine in a healthy young woman.

A 34-year-old woman collapsed secondary to ventricular fibrillation 3 hours following the ingestion of ergotamine tartrate for migraine. She underwent defibrillation and recovered rapidly without any subsequent consequences. The mechanism of action and the side effects of ergotamine and other antimigraine drugs are discussed. We hypothesize that a coronary spasm induced by ergotamine could be the aetiologic factor leading to ischaemic ventricular fibrillation.

Adult↗

Primary cardiac lymphoma: diagnosis by transvenous biopsy under transesophageal echocardiographic guidance.

A 64-year-old woman presenting with dizziness and atrioventricular conduction disturbances was found to have a right atrial mass by two-dimensional transthoracic echocardiography. Transesophageal echocardiography allowed further delineation of the tumor and safe performance of transvenous biopsy, thereby obviating the need for surgery. Pathological examination of the biopsy specimen as well as the absence of extracardiac location established the diagnosis of primary cardiac lymphoma.

Biopsy, Needle↗

Space proton flux and the temporal distribution of cardiovascular deaths.

The influence of solar activity (SA) and geomagnetic activity (GMA) on human homeostasis has long been investigated. The aim of the present study was to analyse the relationship between monthly proton flux (> 90 MeV) and other SA and GMA parameters and between proton flux and temporal (monthly) distribution of total and cardiovascular-related deaths. The data from 180 months (1974-1989) of distribution in the Beilinson Campus of the Rabin Medical Centre, Israel, and of 108 months (1983-1991) from the Kaunas Medical Academy, were analysed and compared with SA, GMA and space proton flux (> 90 MeV). It was concluded: (1) monthly levels of SA, GMA and radiowave propagation (Fof2) are significantly and adversely correlated with monthly space proton flux (> 90 MeV); (2) medical-biological phenomena that increase during periods of low solar and/or geomagnetic activity may be stimulated by physical processes provoked by the concomitant increase in proton flux; (3) the monthly number of deaths related (positively or negatively) to SA are significantly and adversely related to the space proton flux (> 90 MeV).

Adult↗

Distribution of deaths from ischemic heart disease and stroke. Environmental and aging influences in men and women.

UNLABELLED: The goal of this study was to check: 1) links between month of the year (1-12), monthly solar activity (SA) and monthly geomagnetic activity (GMA) with the temporal distribution of deaths from ischemic heart disease (IHD) and stroke in Israel and Lithuania (48 months); 2) related age and gender differences; 3) temporal connection between deaths from IHD and suicide and their relationship to SA and GMA, as was suggested in our previous study in Israel. RESULTS: Total deaths from IHD in Lithuania showed a trend towards a link with SA (r = 0.25, p = 0.09) and a highly significant correlation for females (r = 0.37, p = 0.00096) but not for males. Age < 74 showed no correlation with SA or GMA in females, but a negative correlation with SA in males (r = -0.513, p = 0.0002). At age > 74 both females (r = 0.467, p = 0.0006, n = 20763) and males (r = 0.476, p = 0.0006, n = 14682) showed a highly significant correlation with SA and a negative correlation with 1-12 months of the year, with deaths concentrating at the beginning of the year (r = -0.32, p = 0.002). Number of monthly suicide and IHD deaths were negatively related to each other (r = -0.45, p = 0.0014). CONCLUSIONS: 1) Around age 70 an increasingly positive relationship between the temporal distribution of deaths from IDH and SA is seen. 2) Gender differences in links to SA are partially a consequence of the higher number of deaths in females from IHD at age > 74.3) Monthly number of suicides is inversely related to number of deaths from IHD.

Age Factors↗

Severe syncope due to the application of a pacemaker telemetry wand.

We report a case of a transient defective anodal contact between pacemaker ground plate and patient's tissues (the so-called dry pocket). During unipolar-DDD pacing, mild compression of the pocket with the telemetry head caused a severe syncope, due to asystole and secondary to complete loss of ventricular capture. Normal pacemaker function resumed with bipolar pacing configuration.

Equipment Failure↗

Relationship between suicide and myocardial infarction with regard to changing physical environmental conditions.

In recent years, the possible association of changes in mortality from cardiovascular disease and myocardial infarction (MI) and deaths related to violence and the suicide rate has been repeatedly discussed. This study examined the relationship between cosmic physical changes (solar, geomagnetic and other space activity parameters) and changes in the total number of in-hospital and MI-related deaths and deaths from suicide to determine if a relationship exists between the distribution of total and MI-related deaths with suicide over time; some differences in the serotonergic mechanisms involved in the pathogenesis of MI and suicide were also taken into account. All suicides (n = 2359) registered in the State of Israel from 1981 to 1989 (108 months) were analysed and compared with the total number of deaths (n = 15601) and deaths from MI (n = 1573) in a large university hospital over 180 months (1974-1989). The following were the main features of the Results. (1) Monthly suicide rate was correlated with space proton flux (r = 0.42, P = 0.0001) and with geomagnetic activity (r = -0.22, P = 0.03). (2) Total hospital and MI-related deaths were correlated with solar activity parameters (r = 0.35, P < 0.001) and radiowave propagation (r = 0.52-0.44, P < 0.001), an with proton flux (r = -0.3 to -0.26, P < 0.01). (3) Monthly suicide distribution over 108 months was correlated with MI (r = -0.33, P = 0.0005) and total hospital mortality (r = -0.22, P = 0.024). (4) Gender differences were prominent.(ABSTRACT TRUNCATED AT 250 WORDS)

Cardiovascular Diseases↗

Clinical cosmobiology: the Lithuanian study 1990-1992.

The numbers of deaths from ischaemic heart disease (IHD), stroke (CVA), all accidents except vehicular, vehicular accidents and suicide (overall total, totals for men and women) per month for 36 months (1990-1992) in Lithuania were analysed in relation to: (1) month of the year (1-12); (2) geomagnetic activity; and (3) solar activity. A total of 122227 deaths (64490 men and 57737 women) was studied, and the results compared with those obtained in an earlier study in Israel, differing geographically and climatically from Lithuania. It was shown that the time of year, solar activity, and geomagnetic activity were related to the monthly death distribution, especially regarding death from IHD and suicide. Age and gender differences were apparent in the relationship between death distribution and physical environmental factors. At age > 70 years, many of these relationships change. The monthly distribution of deaths from IHD and suicide are adversely correlated with solar activity and with each other. Differences are presumed in serotoninergic effects as caused by environmental influences.

Accidents↗

QRST changes during and after percutaneous transluminal coronary angioplasty.

This study reports preliminary results on 45 patients who underwent percutaneous transluminal coronary angioplasty (PTCA); 120-lead data (including the 12-lead standard electrocardiogram [ECG]) were recorded before, during, and after balloon inflation. Twenty-one patients underwent PTCA for left anterior descending coronary disease, 13 for right coronary artery disease, and 10 for left circumflex; 1 patient had combined left anterior descending and right coronary artery disease. In each patient, voltage data recorded during the various phases of the procedure were compared with the patient's own baseline data. In 18 patients, 120 leads were also recorded 24 hours after PTCA. In this study, the usefulness of the standard 12-lead ECG was investigated in locating the coronary artery being occluded, in elucidating the mechanisms of the QRS changes, and in identifying changes occurring 24 hours after completion of the procedure. Results indicate that the observation of ST elevation in the 12-lead ECG may lead to ambiguous interpretation. Also, limiting observation to ST-T patterns alone instead of including QRS changes further hampers correct identification of the involved vessel. QRS modifications during inflation are interpreted as conduction disturbances, although other mechanisms are evoked: study of surface maps may contribute to the understanding of these mechanisms. Changes present 24 hours later are visible in the standard leads, but again, in the absence of the thoracic potential distribution, these are difficult to interpret. These changes were different from those observed after cessation of inflation at the end of the procedure. It is hypothesized that next-day changes may reflect reperfusion injury and/or represent myocardial stunning. Presence of injury and reversibility of changes require further investigation. Also, biochemical markers such as creatine kinase-MB mass, creatine kinase-MB activity, myoglobin, and troponin-T may help elucidate the significance of these findings.

Angioplasty, Balloon, Coronary↗

Intraocular pressure (IOP) in relation to four levels of daily geomagnetic and extreme yearly solar activity.

The link between geomagnetic field activity (GMA), solar activity and intraocular pressure (IOP) in healthy individuals was investigated. The IOP of 485 patients (970 eyes) was recorded over three nonconsecutive years (1979, 1986, 1989) which were characterized by maximal solar activity (1979, 1989) or minimal solar activity (1986). The measurements were also correlated with four categories of GMA activity: quiet (level I0), unsettled (II0), active (III0), and stormy (IV0). Participants were also differentiated by age and sex. We found that IOP was lowest on days of level IV0 (stromy) GMA. The drop in IOP concomitant with a decrease in GMA level was more significant during periods of low solar activity and in persons over 65 years of age. There was a trend towards higher IOP values on days of levels II0 and IV0 GMA in years of high solar activity. Differences between the sexes and among individuals younger than 65 years were not significant. Our results show an interesting aspect of environmental influence on the healthy population.

Adult↗

Geophysical variables and behavior: LXIX. Solar activity and admission of psychiatric patients.

Numbers of first admissions per month for a single psychiatric unit, from 1977 to 1987, were examined for 1829 psychiatric inpatients to assess whether this measure was correlated with 10 parameters of geophysical activity. Four statistically significant values were 0.197 with level of solar radioflux at 2800 MHZ in the corresponding month, -0.274 with sudden magnetic disturbances of the ionosphere, -0.216 with the index of geomagnetic activity, and -0.262 with the number of hours of positive ionization of the ionosphere in the corresponding month. Percentages of variance accounted for were very small.

Adolescent↗

Hospital cardiovascular deaths and total distribution of deaths in 180 consecutive months with different cosmic physical activity: a correlative study (1974-1988).

The dynamics of total hospital deaths from different kinds of cardiovascular diseases in one 1000-bed hospital were compared with 10 monthly cosmic/solar and geomagnetic physical activity parameters. Data used were of 180 consecutive months; 15,601 deaths including 5667 from cardiovascular diseases were included in this study. It was concluded that the number of monthly hospital deaths shows a highly significant correlation with monthly solar physical activity.

Cardiovascular Diseases↗

Admissions of patients with epileptic seizures (E) and dizziness (D) related to geomagnetic and solar activity levels: differences in female and male patients.

Admissions of 762 patients for epileptic seizures and 1553 for dizziness were studied for the connection with the level of monthly and yearly solar activity in the 11-year solar cycle and with four levels of daily geomagnetic activity levels (400 epileptic patients and 802 patients suffering with dizziness). The most significant differences of the studied groups were in the male/female ratio in different conditions of solar and geomagnetic activity. Changes in the group of epileptic patients were accompanied by similar, but adverse changes in the group suffering from dizziness. Different conditions of responses of females and males to environmental changes can explain the demonstrated results.

Adult↗