Biomedical subjects

E Sohar

Publications and source records attributed to E Sohar.

At least 73 records · Page 4Linked to original sources

PubMed1976

Effects of exposure to Finnish sauna.

Pathophysiological effects of exposure to Finnish sauna (80 to 90 C, 30 to 40% relative humidity) were investigated in 60 volunteers--33 men and 27 women aged between 18 and 63 years. The volunteers entered the sauna after a rest period of 20 min, and remained there for 20 min or until they suffered discomfort. Weight, height, rectal and skin temperatures, blood pressure, heart and respiratory rates and ECG were recorded 20 min prior to the sauna, during the sauna, and 20 min after leaving the sauna. Marked physiological changes appeared in the first few minutes in the sauna without any prodromal warning. At the 20th min the mean heart rate was 143 +/- 25 (SD) beats/min (greater than 160 beats/min in 32% of the subjects). Mean rectal temperature was 38.6 +/- 0.6 (SD) C (greater than 39 C in 22%): mean skin temperature was 40.4 +/- 1 (SD) C (greater than 40 C in 35%); mean systolic blood pressure was 130.5 +/- 26.6 (SD) mm Hg (greater than 160 mm Hg in 17%); and mean diastolic pressure was 66.6 +/- 15.9 (SD) mm Hg (greater than 50 mm Hg in 17%). The mean total sweat loss was 457 +/- 264 (SD) g. Three subjects experienced syncope, and one developed an anginal attack; ECG changes suggestive of coronary insufficiency were recorded. No decrease in blood pressure occurred in patients with preexisting high blood pressure. It is concluded that sauna bathing involves dangers to the bather's health, which may appear suddenly, without prodromal warning signs.

Adolescent↗

PubMed1976

Heat stress: comparison of short exposure to severe dry and wet heat in saunas.

Sixty subjects, 33 males and 27 females, from 18 to 63 years of age, were exposed to two kinds of saunas: the Finnish sauna (dry sauna) with an air temperature of 80 to 90 C and a relative humidity of 50%, and the wet sauna with an air temperature of 45 to 50 C and a relative humidity of 100%. There was a rest period of one week between the two experiments. For the 60 subjects the mean duration in the wet sauna was 19.6 minutes and in the dry sauna it was 17.4 minutes. After 10 and 20 minutes of exposure in the wet sauna the mean rectal temperature was 38.1 and 38.5 respectively, the mean skin temperature 40.2 and 40.4 C, the respiratory rate 21 and 22.9 breaths/min, the pulse rate 113 and 135.4 beats/min, the mean diastolic pressure 76.1 and 71.9 mm Hg, and the mean systolic pressure 115.7 and 123.5 mm Hg. Comparing the different physiological parameters in both saunas showed significant differences only during the first 10 minutes: a greater drop in diastolic blood pressure, a higher increase in systolic blood pressure, and a greater rise in pulse rate in the dry sauna. After 20 minutes there were no significant differences between any of the above parameters. It is concluded that the heat strain and hence the risk in both saunas are similar and exposure in either sauna exceeding 10 minutes may be dangerous.

Adolescent↗

PubMed1976

In vitro synthesis of "amyloid"fibrils from insulin, calcitonin and parathormone.

Insulin, calcitonin and parathyroid hormone subjected to one of two procedures-acidification and heating or incubation with mouse kidney lysosomal extracts-assumed a nonbranching fibrillar structure, 7 to 10 nm in diameter. The preparations showed green birefringence after Congo red staining. The in vitro synthesis from different hormonal polypeptides of fibrils, fulfilling the criteria for the identification of amyloid, indicates that these criteria are related to conformational rather than to compositional properties, and suggests that these hormones may provide the subunit of the amyloid formed in the corresponding endocrine organs.

Amyloid↗

PubMed1975

Hyperglycemia during acute myocardial infarction. A six-year follow-up study.

Fasting blood glucose (FBG) level and oral glucose tolerance (OGT) were determined in 169 patients within 72 hours of an acute myocardial infarction. Elevated FBG levels were found in 47.5% and a reduced OGT in 72.5%. Of 32 patients who died in the hospital, FBG value was elevated in 72% and the OGT was abnormal in 89%. Of 91 patients who survived longer than six years, the initial FBG level had been elevated in 33%, and the OGT had been abnormal in 67%. Eighty percent of the group with initially raised FBG values had either latent or overt diabetes, while more than 95% of the patients with initially normal FBG values had a normal OGT. Fifty-five percent of the patients with abnormal OGT during myocardial infarction showed normal OGT six years later. The FBG level shortly after an acute myocardial infarction is a better guide to prognosis and to the prediction of subsequent development of diabetes mellitus than the OGT test.

Acute Disease↗

PubMed1975

The effect of heat treatment on the damage and recovery of the protein synthesis mechanism of human kidney cell line.

The effect of supraoptimal temperature on the suppression and recovery of protein synthesis activity in cultures of human kidney cell line was studied. It was shown that 44 degrees C is a critical temperature to these cells, and after exposure to this temperature for 3 hours no recovery of protein synthesis activity could be detected. The cloning efficiency of cells exposed to 44 degrees C for 2 hours was irreversibly reduced to zero. Protein synthesis at 43 degrees C was much less affected, showing considerable recovery after eight hours exposure. Differences in heat susceptibility of individual cells in the culture were observed, but the reason for this heterogeneity is not yet known.

Autoradiography↗

PubMed1975

Stimulation of murine amyloidosis by a dializable product from pretreated donors.

Amyloid was obtained in recipient mice by implantation into their peritoneal cavity of a dialysis bag containing spleen cells obtained from donor mice which were treated with casein for 6 days and while no amyloid was found in their implanted spleens. The transplantations were performed with 2 cell systems, one containing whole spleen suspension and the other washed cells. Amyloid was obtained in the recipient mice within 6 days after the implantation and in a more massive quantity than in mice treated by casein for a similar period.

Amyloid↗

PubMed1974