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Biomedical subjects

E Smythe

Publications and source records attributed to E Smythe.

22 records · Page 2Linked to original sources
PubMed1988

Itraconazole in the treatment of acute vaginal candidiasis.

In a multicentre open prospective study itraconazole was evaluated in the treatment of acute vaginal candidiasis. Two dosage regimens were tested--200 mg twice a day for 1 day and 200 mg twice a day for 2 days. There were no statistically significant differences between these dosages, and cure rates at 7 and 28 days after treatment were 83% and 75% respectively. These are marginally lower than those produced by longer courses of oral ketoconazole (Nizoral; Janssen) and vaginal econazole nitrate but the advantages are better patient compliance and greater cost-effectiveness.

Adolescent↗
PubMed1985

Analgesics for pain relief after gynaecological surgery. A two-phase study.

A two-phase, double-blind study was performed to assess the efficacy of various drugs in the relief of postoperative pain. Oral analgesia with two compounds (paracetamol 320 mg, caffeine 32 mg, codeine phosphate 8 mg and meprobamate 150 mg (Stopayne; Rio Ethicals) and dipyrone 500 mg, pitofenone hydrochloride 5 mg and fenpiverinium bromide 0,1 mg (Baralgan HS; Albert)) was found to produce satisfactory pain relief, and it is suggested that these oral compounds may be used from 12 hours postoperatively in uncomplicated cases. Parenteral administration of either pethidine 100 mg or dipyrone 2500 mg was found to be an ineffective form of pain relief, and it is suggested that the use of these drugs should be reviewed. In both phases of the study side-effects were infrequent and mild, and smoking did not have an influence on the results.

Acetaminophen↗
PubMed1985

Ketoconazole in the treatment of vaginal candidiasis.

In a preliminary open prospective study ketoconazole (Nizoral; Janssen) 200 mg twice daily for 5 consecutive days was found to be extremely effective in treating vulvovaginal candidiasis, producing cure rates of 96% at 7 days and 92% at 28 days. The oral route of administration has definite advantages over the vaginal route and improves patient compliance. No side-effects related to treatment were found in this study.

Administration, Oral↗