Search PubMed⌕ Search

Biomedical subjects

E Smith

Publications and source records attributed to E Smith.

At least 145 records · Page 8Linked to original sources
PubMed1997

[HIV/AIDS development in Denmark and Sweden. Are there differences?].

National surveillance data from Denmark and Sweden were analyzed for trends in the incidence of HIV and AIDS. By the end of 1995, the cumulative number of AIDS cases was higher in Denmark than in Sweden, but since the annual incidence was still increasing in Sweden and slightly decreasing in Denmark, the Denmark:Sweden ratio of the overall annual AIDS incidence has decreased since 1992, and so has this ratio of incidence among homo/bisexual men. The cumulative number of acquired infections was estimated to be higher in Denmark than in Sweden, although the bi-annual proportional increase in incidence from 1987 to 1993 was higher in Sweden than in Denmark. In both countries, the annual number of new identified HIV infections among homo/bisexual men has become stable, although the Denmark:Sweden ratio has decreased since 1990. In conclusion, the national epidemiological data do not indicate that the Swedish strategy has been more effective than the Danish in preventing new HIV infections.

Acquired Immunodeficiency Syndrome↗
PubMed1997

[Status on the HIV/AIDS epidemic in Denmark by the end of 1995].

Data from the national Danish surveillance of HIV and AIDS were analysed in order to describe the epidemiological trends and to estimate the HIV incidence and the future AIDS-epidemic. An increasing number of AIDS cases were women and were heterosexually acquired. A stable number of new HIV-infections were identified during the 1990's, among whom women represented an increasing proportion. Half of identified women were immigrants and 40% of all cases were heterosexually acquired. An increasing number of female AIDS cases and AIDS cases heterosexually acquired can be expected in the near future. Estimates showed that probably 5000 people have acquired HIV, among whom 1400 have died. The HIV incidence may be 236 cases per year, close to the number of AIDS deaths, giving a steady-state like situation. The number of living HIV-infected persons who are homosexual men is probably decreasing, while the number with heterosexually acquired HIV may increase. However, the HIV-incidence and -prevalence is still especially high among homosexual men.

Acquired Immunodeficiency Syndrome↗
PubMed1997

Upregulation of cortactin expression during the maturation of megakaryocytes.

Cortactin is a potent filamentous actin-binding protein acting as a prominent substrate of Src tyrosine kinases. We have evaluated cortactin expression in a series of murine tissues and shown an abundant expression of cortactin in megakaryocytes and platelets. Cortactin, but not its related protein HS1, is upregulated during the phorbol 12-myristate 13-acetate (PMA)-mediated maturation of a human megakaryoblastic cell line CMK. Although the expression of Src-related kinases is also upregulated more rapidly than cortactin in PMA-treated CMK cells, tyrosine phosphorylation of cortactin appears to be only transiently elevated 4 days after PMA stimulation. In addition, cortactin expression is induced by thrombopoietin and interleukin-3 in megakaryocytes derived from murine bone marrow cells. Thus, cortactin represents a megakaryocyte-specific gene in bone marrow and the interaction of Src kinases with cortactin may be involved in the maturation of megakaryocytes.

Animals↗
PubMed1997

Frequency and effects of teachers' voice problems.

This study compared the frequency and effects of voice symptoms in teachers to a group of individuals employed in other occupations. Teachers were more likely to report having a voice problem (15 vs. 6%), having 10 specific voice symptoms, and having 5 symptoms of physical discomfort. They averaged almost 2 symptoms compared with none for nonteachers. Likewise, teachers were more likely to perceive that a voice problem would adversely affect their future career options, had done so in the past, and was limiting their current job performance. Over 20% of teachers but none of the nonteachers had missed any days of work due to a voice problem. These findings suggest that teaching is a high-risk occupation for voice disorders and that this health problem may have significant work-related and economic effects.

Adult↗
PubMed1997

Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.

After 582 allogeneic bone marrow transplants, we have encountered four patients (0.7%) who developed transient unilateral or bilateral sixth nerve palsies. Three of the four patients also had bilateral ptosis. These signs resolved 24-48 h after cyclosporin and ganciclovir were discontinued. One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity. We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.

Abducens Nerve↗
PubMed1997

Prevalence of specific language impairment in kindergarten children.

This epidemiologic study estimated the prevalence of specific language impairment (SLI) in monolingual English-speaking kindergarten children. From a stratified cluster sample in rural, urban, and suburban areas in the upper midwest, 7,218 children were screened. The language screening failure rate was 26.2%. Children who failed the screening and a similar number of controls were then administered a diagnostic battery (n = 2,084) that provided for a diagnosis of SLI using common diagnostic standards. Results provided an estimated overall prevalence rate of 7.4%. The prevalence estimate for boys was 8% and for girls 6%. Variation in prevalence was found among children of different racial/cultural backgrounds; however, these background variables were found to be correlated with parental education, which was also associated with SLI. The parents of 29% of the children identified as SLI reported they had previously been informed that their child had a speech or language problem. The prevalence estimates obtained fell within recent estimates for SLI, but demonstrated that this condition is more prevalent among females than has been previously reported. Also, the clinical identification of these children remains low among kindergarteners.

Child↗
PubMed1997

Epidermal growth factor (EGF) and EGF receptor in hypospadias.

OBJECTIVE: To determine whether alterations in epidermal growth factor (EGF), which plays a major role both in the masculinization of the genitourinary tract and in wound healing, or EGF receptor (EGFR) expression are associated with hypospadias. PATIENTS AND METHODS: The prepuces from 22 children undergoing circumcision (median age 27 months, range 5-87) and skin biopsies from 16 children undergoing surgery for hypospadias (median age 12 months, range 3-57) were studied. Fourteen patients had distal, one had mid-shaft and one had penoscrotal hypospadias. Immunoperoxidase staining was carried out for EGF and EGFR and the density of the staining quantified using image cytometry by an operator unaware of the diagnosis. RESULTS: The median EGF density in foreskins obtained by circumcision was 75% (mean 73, SE 2.1) compared with 54% (mean 52, SE 3.9) for tissue samples from patients with hypospadias (P < 0.001); the mean EGFR was similar in both materials. CONCLUSION: The mean EGF value was deficient in skin adjacent to hypospadias defects compared to normal phallic skin, suggesting that the inadequate expression of EGF may be related to the aetiology of hypospadias and to possible wound complications following surgery for hypospadias.

Child↗
PubMed1997

A thalamic contribution to arousal-induced, non-photic entrainment of the circadian clock of the Syrian hamster.

It is well established that the circadian clock of the suprachiasmatic nuclei (SCN) is entrained by light. More recently, the potent effects of arousing, non-photic cues on the clock have been recognized. The neural mediators of non-photic entrainment are yet to be identified. To examine the contribution of the thalamic intergeniculate leaflet (IGL) and its NPY-immunopositive projection, the geniculo-hypothalamic tract to non-photic entrainment by arousal, male Syrian hamsters received lesions of the IGL (IGLX) which ablated NPY-immunoreactivity in the SCN. Their circadian responses to both photic and non-photic cues were then tested. Lesions resulted in a delay in the timing of activity onset following lights out, but had no effect on the behavioural or cellular circadian responses to phase-advancing light pulses presented at circadian time (CT) CT19 (where CT12 represents the time of activity onset). Injection with a benzodiazepine (chlordiazepoxide, 100 mg/kg) at CT6 suppressed wheel-running, increased general locomotion of intact controls and induced large phase advances of the circadian rhythm of wheel-running. Chlordiazepoxide also inhibited wheel-running in lesioned animals, but there was no significant increase in general locomotion and the lesioned animals did not phase advance. Serial arousal by injection of saline at intervals of 23.5 h for 6 days entrained the circadian rhythm of wheel-running of intact hamsters and was associated with an increase in general locomotor activity. Entrainment by serial arousal was abolished by IGLX. However, the lesioned animals did show a clear behavioural response to every presentation of the non-photic cue. These results show that the IGL is a necessary component of the neural pathways mediating both arousal- and benzodiazepine-induced non-photic entrainment.

Animals↗
PubMed1997

Impact of follow up letters on non-attenders for breast screening: a general practice based study.

OBJECTIVE: To determine the effectiveness of follow up letters to non-attenders for screening on the breast screening uptake in practices with a low preliminary uptake of screening. DESIGN: Observational study of two groups of general practices. In 40 of these practices, the preliminary uptake of screening was less than 60%. These 40 practices were offered help from a clerical officer to check names and addresses of non-attenders, and to send non-attenders a reminder letter. SETTING: 93 general practices in South West London in 1995-96. MAIN OUTCOME MEASURES: Preliminary and final uptake of breast screening. RESULTS: Breast screening uptake increased by an average of 4.6% in the 40 intervention practices compared with 1.6% in the 53 control practices (difference 3.0%, P < 0.0001). However, the absolute increase in the uptake of screening in the intervention group was small (from 53.8% to 58.5%). The marginal cost for each additional women screened was Pounds 7 (compared with an average cost for each women screened of Pounds 27). CONCLUSIONS: Reminder letters can help increase the uptake of screening in practices with a low preliminary uptake of breast screening. However, they have a limited role in improving the uptake of breast screening in inner city areas, and other methods of increasing uptake therefore need to be developed and evaluated.

Breast Neoplasms↗
PubMed1997

Fluorine-18-FPCT: a PET radiotracer for imaging dopamine transporters.

UNLABELLED: Fluorine-18-labeled 2 beta-carbomethoxy-3 beta-(4-chlorophenyl)-8-[-3-fluoropropyl) nortropane (FPCT) has been synthesized as a new dopamine transporter imaging agent. METHODS: Fluorine-18 was introduced into 2 beta-carbomethoxy-3 beta-(4-chlorophenyl)-8-[-3-fluoropropyl) nortropane by preparation of 1-[18F]fluoro-3-iodopropane followed by alkylation of 2 beta-carbomethoxy-3 beta-(4-chlorophenyl)nortropane. RESULTS: Tissue distribution studies in rats with [18F]FPCT showed high striatal uptake (0.70% dose/g at 60 min; 0.38% dose/g at 120 min) and good striatal-to-cerebellum ratios (5.5 at 60 min; 6.2 at 120 min). Imaging studies in rhesus monkeys (n = 2) with [18F]FPCT showed high uptake and retention in the putamen (P) (P = 0.03%-0.12% dose/g; at 115 min) and good putamen-to-cerebellum ratios of 3.40-3.43 at 115 min. Plasma metabolites were analyzed in rhesus monkeys (n = 2) by ether extraction and HPLC. The radioactivity in the ether-extractable fraction displayed a single peak that corresponded on HPLC to unmetabolized authentic FPCT. CONCLUSION: These results suggest that [18F]FPCT is an excellent candidate for PET imaging of dopamine transporters.

Animals↗
PubMed1997

Bribery and co-operation.

NHS trusts are still looking for ways to maintain intensive continuing care in the community for people with severe mental illness. The US model of assertive community treatment (ACT) may be the answer.

Community Mental Health Services↗