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Biomedical subjects

E Sener

Publications and source records attributed to E Sener.

29 records · Page 2Linked to original sources
PubMed1997

Synthesis and microbiological activity of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides as the possible metabolites of antimicrobial active benzoxazoles.

Synthesis of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides (5a-k) were described in order to determine their in vitro antimicrobial activity against 3 Gram-positive, 3 Gram-negative bacteria and the fungus Candida albicans comparing with several control drugs. The derivative 5e was found active at a MIC value of 25 micrograms/ml against the whole tested Gram-positive bacteria strains and the Gram-negative microorganism Klebsiella pneumoniae. Moreover, the synthesized compounds 5a-k exhibited significant antibacterial activity against the enterobacter Pseudomonas aureginosae when compared to the control drugs. For the antifungal avtivity against C. albicans, the compound 5k was found more active than the other synthesized derivatives. On the other hand, the antimicrobial activity of some of these acetamide derivatives (5c, 5d, 5e, 5j and 5k) which are the possible metabolites of benzoxazoles, were also compared with their cyclic analogues 6-10. However, most of the MIC values of the benzoxazole derivatives provided better activity than the compared acetamides, while some others of the acetamide derivatives possessed either one fold improved (5d, 5e and 5j) or the same potency (5c, 5d, 5e, 5j and 5k) against the tested microorganisms.

Acetamides↗
PubMed1996

Hemodynamic effects of acute intestinal ischemia.

Twelve animals entered in this study with the aim of documenting that superior mesenteric artery small occlusions lasting for one hour have adverse effects on the myocardium. Three hours after cross clamp removal CO decreased to 1.07 +/- 0.11 from 1.99-0.09 a preoperative value (p < 0.01) and PCWP increased to 17 +/- 3 from 8 +/- 3 a preoperative value. MOE reduced to 40-5% 3 hours after cross clamp removal. MLE was -0.21 +/- 0.11 three hours after clamp removal. Changes in MOE and MLE were commented as a defect in myocardial aerobic metabolism. As a result of this study it was concluded that toxic mediators are released from the intestine being reperfused after temporary occlusions of the SMA impair myocardial metabolism, resulting in decreased hemodynamic functions.

Animals↗
PubMed1995

Late results of mitral valve replacement with Carpentier-Edwards high profile bioprosthesis in young adults.

Carpentier-Edwards (C/E) high profile supra-annular porcine bioprostheses were implanted in 163 patients between September 1982-February 1987 in the mitral position due to rheumatic disease. The patients' ages ranged between 15 and 58 years (mean: 36.5 +/- 11.5). One hundred-two of the patients (62.5%) were female. The hospital mortality was 9.8% (16/163). The total cumulative follow-up period was 1093 patient-years (p-y) with a mean of 7.3 +/- 3.5 p-y (range 6 months-12 years). Linearised occurrence rates of the late complications were as follows: Thromboembolism 0.82%/p-v, anticoagulant-related bleeding 1.0%/p-y, prosthetic valve endocarditis 0.09%/p-y. Actuarial survival rates for 5 and 12 years were 87% +/- 6% and 76% +/- 9%, respectively, with 95% confidence limits. Freedom from structural deterioration was 92% +/- 5% for 5 years and 44% +/- 11% for 12 years. Freedom from all valve-related complications was 81% +/- 7 for 5 years and 26% +/- 9 for 12 years. In conclusion, this prosthesis provides satisfactory clinical performance in young population despite the high risk of degeneration with good prognosis and better tolerability of reoperation.

Actuarial Analysis↗
PubMed1995

Risk factors of reoperations for prosthetic heart valve dysfunction in the ten years 1984-1993.

From January 1984 to December 1993 a total of 154 patients (89 men and 85 women) required 160 reoperations for prosthetic heart valve dysfunction. Four patients required a second, two patients a third reoperation. Age was (mean +/- SD [range]) 38.8 +/- 10.2 (17 to 64) years. The primary operation was mitral valve replacement in 105 patients, aortic valve replacement in 20, and both aortic and mitral valve replacement in 29. The time interval between initial valve replacement and reoperation was 66.4 +/- 40 (3 to 288) months for the mechanical prostheses and 68.7 +/- 32 (24 to 140) months for bioprostheses; the difference was not statistically significant. Primary tissue failure was the most common cause of the reoperation for bioprostheses and valve thrombosis for mechanical prostheses. The hospital mortality rate was significantly higher in the replacement of mechanical prostheses (14/58 = 24.1% vs. 7/102 = 6.8%, p = 0.004). Low preoperative functional capacity and valve thrombosis were linked to higher mortality rates. It is discussed that monoleaflet mechanical valves yielded the highest operative mortality and that, excluding these, the risk of mortality in prosthetic valve reoperations today does not differ much from that in primary valve replacements.

Adult↗
PubMed1995

Low dose anticoagulation after St. Jude Medical prosthesis implantation in patients under 18 years of age.

Between September 1986 and January 1994, 129 St. Jude Medical prostheses were implanted in 113 patients who were 18-year-old or younger at the Cardiovascular Surgery Clinic of Turkiye Yuksek Ihtisas Hospital. Thirty-seven patients underwent aortic, 60 patients mitral and the remaining 16 patients double valve replacement. Overall hospital mortality was 7.9% (9/113). All patients received 2.5 mg/day warfarin from the first postoperative day, in addition 225 mg/day dipyridamole and 100 mg/day aspirin was given following the removal of mediastinal tubes. This regimen was continued indefinitely thereafter. Follow up period ranged between 2-94 months. Total follow up experience was 276.4 patient-years. There were five late deaths; the cause of death was prosthetic valve thrombosis in two patients, intracerebral hemorrhage in one, cardiomyopathy in one, and sudden death in one. Other late complications included one endocarditis, a further anticoagulant related bleeding and one paravalvular leak. There was no case of cerebral or peripheral embolism reported. Seven-year actuarial survival was 92.4 +/- 6.8% for the entire group, 84.6 +/- 13.8% after mitral and 100% after aortic or double valve replacement. In conclusion, low dose oral anticoagulation after heart valve replacement with St. Jude Medical prosthesis in this age group showed satisfactory clinical results.

Adolescent↗
PubMed1993

Pseudoaneurysm of the tibioperoneal trunk.

A young woman with an iatrogenic coagulation defect related to a mechanical mitral valve prosthesis developed a pseudoaneurysm of the tibioperoneal trunk after a minor blunt injury. The importance of minor blunt trauma in such cases and the surgical approach are reviewed.

Adult↗
PubMed1992

Surgical approach to pseudoaneurysms with Behçet's disease.

One of the arterial complications of Behçet's disease, arterial false aneurysms, has a sudden onset of symptoms and high mortality risk if left untreated. Four cases with arterial pseudoaneurysms of 3 male patients is reported and the choice of surgical intervention is emphasized. It is underlined that PTFE grafts are the graft of choice in reconstructions for arterial complications of Behçet's disease.

Adult↗
PubMedDate not supplied

Results of right coronary artery endarterectomy with or without patchplasty.

We report preoperative and early postoperative findings of 286 coronary bypass patients operated between 1988 and 1998 who had endarterectomy and/or patchplasty to the right coronary artery. In this retrospective study there were 61 cases with only saphenous vein patchplasty to the right coronary artery (patch group), 57 patients who underwent endarterectomy and patchplasty (open-patch group), and 229 patients having closed endarterectomy to the right coronary artery (closed group). A group of 150 patients having a saphenous vein graft to the right coronary artery without endarterectomy were chosen as a control group. Gender, age, family history, smoking history, diabetes, hyperlipidemia, hypertension, nature of the angina, severity of the coronary artery disease, left ventricular functions, preoperative rhythm, and electrocardiographic patterns were evaluated for their effect on early mortality among groups. No significant difference was detected. Positive inotropic and mechanical support need was higher in the closed group at the end of the operation and in the intensive care unit. Duration of cardiopulmonary bypass and clamp time was higher in the open-patch group. Atrial fibrillation in the early postoperative period was more frequent in the patch and closed groups. Complete atrioventricular block development and the need for a pacemaker were higher in the open-patch and closed groups. Non-Q wave myocardial infarction was more frequent in the closed group. Mortality rates were higher in the open-patch and closed groups. We conclude that endarterectomy to right coronary artery should be avoided if possible, and patchplasty with saphenous vein should be preferred.

Cardiopulmonary Bypass↗
PubMedDate not supplied

Is left main coronary artery stenosis a risk factor for early mortality in coronary artery surgery?

It is accepted universally that the treatment of critical left main coronary artery (LMCA) stenosis is surgical revascularization. This study was designed to evaluate critical LMCA stenosis as a risk factor in coronary artery bypass surgery. We compared the surgical results of 760 patients with critical LMCA disease, including 58 cases who were operated under emergency conditions (LMCA-em) and 702 patients who were operated electively (LMCA-el), with randomly chosen 707 coronary bypass patients (CONT-el) without LMCA disease, but who had double- or triple-vessel disease. Another group of patients (n = 99) who were operated on under emergency conditions (CONT-em) but without LMCA disease were also compared with the corresponding groups. The mortality of LMCA-em group and CONT-em group was markedly higher from the other two groups. Univariate analysis revealed that female gender, older age, presence of diabetes mellitus, poor left ventricular function, and the presence of unstable angina were major risk factors for fatal outcome in LMCA-el and CONT-el groups. Age was also a risk factor in LMCA-em group, as well as unstable angina pectoris. The coexistence of critical right coronary artery disease did not affect the early outcome in both groups with LMCA lesions. In the multivariate analysis, critical LMCA disease was not a risk factor for mortality. Logistic regression analysis revealed diabetes [odds ratio (OR): 3.66], poor left ventricular function (higher left ventricle end-diastolic pressure, OR: 1.08), and emergent operations (OR: 5.09) were risk factors for early mortality. Patients with LMCA disease should have surgery promptly for favorable results, because emergency conditions have higher mortality rates.

Adult↗