Biomedical subjects
Publications and source records attributed to E Selimoğlu.
A 67-year-old man with an enlarged left tonsil underwent a tonsillectomy for the suspicion of malignancy. He had had a dental extraction six months earlier. Clinical and histopathological investigations established the diagnosis of primary tonsillar tuberculosis.
All the aminoglycoside antibiotics now in clinical use are ototoxic. This study was designed to compare the toxic effects of four aminoglycoside antibiotics, streptomycin, gentamicin, amikacin and netilmicin, administered to guinea-pigs systemically (at respective doses of 125 mg/kg, 50 mg/kg, 150 mg/kg or 37.5 mg/kg, twice daily for 1 week) or topically via the transtympanic route (0.25 ml/kg in 4% saline, twice daily for 1 week). Chosen doses were 10-20 times higher than the recommended human dosage. Cochlear damage was observed in all animals that were given systemic and local aminoglycosides. The severity of the cochlear damage was in the order gentamicin, amikacin, streptomycin, netilmicin, with gentamicin being the most toxic. No statistically significant difference between the severity of cochlear damage resulting from the systemic and topical applications was detected.
Faltering growth may be associated with adenotonsillar hypertrophy, but its pathophysiological mechanism is unclear. This study included 29 pre-pubertal children with obstructive adenotonsillar hypertrophy, and aimed to investigate the probable difference in energy intake and serum insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) levels before and 6 months after adenotonsillectomy. Weight and height standard deviation scores, energy intake per kilogram and serum IGF-1 levels were found to be significantly higher 6 months after adenotonsillectomy, indicating that adenotonsillar hypertrophy is associated with poor growth.