Search PubMed⌕ Search

Biomedical subjects

E Seiler

Publications and source records attributed to E Seiler.

30 records · Page 2Linked to original sources
PubMed1981

Effects of sexual maturation on serum lipoproteins.

In 503 healthy Dresden children aged 1 to 17 years we evaluated triglyceride (TG) and total cholesterol (TC) concentrations. The mean TG level decreases up to the 7th year of life followed by a slow increase. During adolescence we found a difference with higher TG levels in females than in males. TC concentrations remain constant from the first to the 11th year of life in both boys and girls. In the 12th and 13th year TC sharply decreases in girls followed by a rise one year later. The same phenomenon occurs in males 1-2 years later. In a second study 372 pupils were investigated consisting to two age groups: 250 boys and girls aged 8 years and 167 young men and women aged 17 years. We estimated TG, TC, high-density lipoprotein cholesterol (HDL-C), and in quite a number of cases HDL apoproteins, estradiol (E2), and testosterone (T). HDL-C concentrations do not differ between sexes in childhood, whereas they do after puberty. We found reduced HDL-C levels in young men. The apoprotein pattern of HDL in male adolescents differs from those of boys, girls, and young women showing an increased relative amount of apo A II. The comparison of E2 and T levels with HDL-C concentrations allows to draw conclusions on the importance of testosterone for the HDL metabolism

Adolescent↗
PubMed1977

[Radioimmunological determination of ACTH and its clinical use].

Since radioimmunological methods have been introduced, it has become possible to measure the concentration of ACTH in human plasma directly. We report on first experiences with commercial testing sets. We proved the clinical usefulness of the determination of ACTH in the cases of 13 healthy adult subjects and 8 healthy children. Furthermore patients with evidence of primary adrenal insufficiency and with disturbances in the hypothalamicpituitary system were included in our investigations. The obtained values are in agreement with the known conception of the hypothalamic-pituitary-adrenal system.

Adrenal Insufficiency↗
PubMed1976

[Radioimmunological determination of unconjugated plasma estradiol and estriol after administration of dehydroepiandrosterone sulfate in late pregnancy].

In 16 normal and pathologic pregnancies we carried out the dehydroepiandrosterone-sulphate loading test by injection of 50 mg DHEA-S-Na intravenously. The plasma concentrations of unconjugated estradiol and estriol were measured by radioimmun-assay. The level of estradiol increased continuously, rising to a maximum 60 min after the injection. In pre-eclamptic patients and cases of intrauterine growth retardation the rise was significantly reduced. There was a good correlation between result of the test and clinical dates. In plasma concentrations of unconjugated estriol no changes could be observed within 3 hours after the injection.

Dehydroepiandrosterone↗