Sclerotherapy of esophageal varices--Argentinian experience.
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Adolescent↗
Biomedical subjects
E Segal
Publications and source records attributed to E Segal.
Trephine drill biopsy in the diagnosis of malignant pleural mesothelioma.
Trephine drill biopsy of the pleura was utilized to establish the diagnosis of malignant pleural mesothelioma in a patient with a thickened pleura without pleural effusion.
Biopsy↗
Adherence of Candida albicans to human vaginal epithelial cells: inhibition by amino sugars.
In vitro adherence of Candida albicans to human vaginal epithelial cells was studied, aimed at identifying the surface components involved in this binding. The inhibitory effect of yeast cell wall components and their constituents on the adherence of yeasts to epithelial cells was tested. Only chitin, its hydrolysate derivative and N-acetylglucosamine, the constituent of chitin, acted as inhibitors. Binding was also inhibited by the amino sugars glucosamine and mannosamine, while none of the other sugars tested (methylated or nonmethylated) exhibited such an effect. These data suggest that the amino groups of sugars are responsible for the inhibition of adherence of this eucaryotic microorganism to epithelial cells.
Acetylglucosamine↗
The effect of amphotericin B on the ultrastructure of Prototheca species.
Prototheca zopfii and prototheca wickerhamii stains were exposed to subinhibitory concentrations of the antimycotic amphotericin B, and the effect of the treatment on their ultrastructure was assessed. The results revealed ultrastructural changes in the treated cells, expressed by swelling of mitochondria, degradation of cell organelles, accumulation of microbody like structures, lipid droplets and starch granules in the cytoplasm, and changes in the inner layer of the cell wall.
Amphotericin B↗
Pulpal response to a glass-ionomer cement in primates.
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Animals↗
Moving boundary electrophoresis and sialic acid content of normal and polycythaemic red blood cells.
Moving boundary electrophoresis has been used for the assessment of the negative charge on erythrocyte membranes. The equipment is easy to construct and simpler to use than the microelectrophoresis technique. There is a direct relationship between the electrophoretic velocity measured by the moving boundary method and the sialic acid content of the red cell membrane. Polycythaemic erythrocytes have a higher electrophoretic mobility and higher sialic acid content than normals. Separation of the erythrocytes according to their densities shows that old polycythaemic erythrocytes have a higher electrophoretic mobility and sialic acid content than young normal ones. This suggests that the difference is not associated with a younger erythrocyte population in polycythaemia vera, but may represent a membrane change in the abnormal erythroid clone present in this disease.
Electrophoresis↗
Protective immunity against murine candidiasis elicited by Candida albicans ribosomal fractions.
Candida albicans ribosomes were prepared from mechanically disrupted cells through differential centrifugation and purification in a sucrose-ammonium sulfate solution. The ribosomes were analyzed chemically and physically and exhibited characteristics of eucaryotic ribosomes (78S). ICR female mice were immunized with two subcutaneous inoculations, 2 weeks apart, of 100 microgram of ribosomes (expressed as ribosomal protein). Immunized mice were challenged either intraperitoneally or intravenously with a lethal dose of live C. albicans cells. The 31-day survival rate of immunized mice challenged intraperitoneally was 64% (mean value) versus 27% in controls; in intravenously challenged mice the survival rate of the immunized animals was about 60%, with no survivors among the controls. In intravenously challenged mice, incomplete Freund adjuvant enhanced the protection elicited by the ribosomes. Protection by ribosomal immunization was obtained against challenge doses causing chronic and acute infection.
Animals↗
Bilateral hilar enlargement as a presenting sign of multiple primary bronchogenic carcinoma.
An asymptomatic patient presented with a chest roentgenogram showing bilateral hilar enlargement compatible with stage II sarcoidosis. However, evaluation revealed double primary bronchogenic carcinoma. A possible pitfall in the non-pathologic diagnosis of sarcoidosis and the implications of double primary bronchogenic carcinoma are discussed.
Carcinoma, Bronchogenic↗
Antibodies to inhalant fungal antigens in patients with asthma in Israel.
Thirty-eight of 97 asthmatic patients, seven of 26 normal subjects and two of 39 patients with chronic obstructive pulmonary disease (COPD) were found to have antibodies to one or more of the inhalant fungi and candida antigens assayed by both immunodiffusion and counterimmune electrophoresis. Atopy was demonstrated in 33 of the 38 asthmatic patients with antibodies. Eleven asthmatics had anti-alternaria antibodies while only two reacted to aspergillus.
Alternaria↗
Experimental vaccination with Candida albicans ribosomes in cyclophosphamide-treated animals.
A study was carried out to determine whether protection against experimental systemic candidiasis can be induced by vaccination with Candida albicans ribosomes in animals compromised by cyclophosphamide (CY) treatment. ICR mice treated with CY showed a reduction in the number of leukocytes and a decrease in spleen and body weights. CY-treated mice were more susceptible to intraperitoneal (IP) or intravenous (IV) challenge with live C. albicans than the untreated animals. Vaccination of CY-treated mice with C. albicans ribosomes, with or without addition of incomplete Freund's adjuvant, led to a partial protection against a lethal IP or IV challenge with live yeasts. These results indicate the possible effectiveness of ribosomal vaccination in protecting the compromised host against experimental candidiasis.
Animals↗
Suppressive action of cytoplasmic and metabolite extracts of Candida albicans on the immune response in guinea pigs.
This study investigated the possibility that Candida albicans components exert a suppressive effect on the immune response of guinea pigs (GP), similar to that of live C. albicans organisms as was previously shown. Hartley GP were inoculated with C. albicans crude cytoplasmic or metabolite (culture filtrate) extracts (containing most of the organism's cell contents or its metabolite and degradation products, respectively). Their immunological responses towards sheep red blood cells (SRBC) were compared with those of GP inoculated with SRBC alone or with SRBC together with live C. albicans organisms. The immunological responses were measured by: 1) rosette formation (RF) of SRBC with peritoneal macrophages, 2) haemolytic plaque formation (PFC) with lymph node-cells, 3) haemagglutination and 4) haemolysis tests. According to the RF tests, inoculation of GP with either cytoplasmic or metabolite extracts resulted in decreased RF as compared to GP inoculated with SRBC only; the decrease was correlated with the protein concentration of the extracts. Inoculation with metabolite extract led to a more diminished RF than with cytoplasmic extract, but less than with live C. albicans organisms. Inoculation of cytoplasmic extracts did not affect the haemagglutinin and haemolysin titers, while that of metabolite extracts resulted in a slight decrease of these titers. The assays for PFC were not conclusive enough to point to a suppressive effect of C. albicans extracts. In summary, it appears that both the cytoplasmic and metabolite extracts of C. albicans exert a partial suppressive effect on the immune response in GP, as judged primarily on the basis of the RF results.
Animals↗
Pathology of Shy-Drager syndrome.
In four patients with the Shy-Drager syndrome, detailed pathological findings in the central nervous system are described. All four patients had striatonigral degeneration, olivopontocerebellar atrophy, pyramidal tract degeneration and ventral horn cell loss. Along with the multisystem degeneration, there was widespread loss of thoracolumbar autonomic neurons, which was demonstrated by comparative cell counts of the intermediolateral horns in two of the four patients. In all four patients, autonomic nuclei of the sacral cord, particularly the Onuf's and intermediolateral nuclei, were severely affected and diffuse cell loss in the nuclei seems to account for disordered bladder, rectal and sexual functions in Shy-Drager syndrome.
Aged↗
Detection of Candida antigen in sera of patients with candidiasis by an enzyme-linked immunosorbent assay-inhibition technique.
A total of 37 serum samples from 27 cancer patients were tested by an enzyme-linked immunosorbent assay-inhibition technique for the detection of Candida antigen. In 20 randomly chosen sera from patients without clinical evidence of candidiasis and in 10 sera from patients proven by autopsy not to have candidiasis, the inhibition ranged up to 17%; in contrast, inhibition ranged from 22 to 56% in all seven patients proven by autopsy to have systemic candidiasis, indicating the presence of Candida antigen in the sera of these patients. This technique appears promising in diagnosing disseminated candidiasis in cancer patients.
Antigens, Fungal↗
Suppressive action of Candida albicans on the immune response in mice.
This study was carried out to determine whether Candida albicans infection has a suppressive effect on the immune response in mice and, if so, whether the suppressive effect influences the response towards T-dependent or T-independent antigens. ICR mice were injected with SRBC with or without C. albicans, or with bacterial LPS with or without C. albicans. The immune response of the mice towards SRBC or towards the LPS was compared by the assay for PFC, hemagglutination and hemolysis tests. The results showed a decrease in the number of PFC in spleens of mice inoculated with SRBC and C. albicans as compared to mice inoculated with SRBC alone, but no decrease in animals injected with LPS and C. albicans as compared to those immunized with LPS alone. No significant differences in the titers of hemagglutinins and hemolysins in sera of mice inoculated with SRBC or with SRBC and C. albicans were observed. C. albicans infection had no effect at all on the hemagglutinins and hemolysins titers in sera of mice inoculated with LPS. These data indicate that C. albicans affects the early phase of the immune response primarily towards T dependent antigens.
Animals↗
Antibody formation in experimental immunizations with Candida albicans ribosomal fractions.
Sera of mice immunized with ribosomal fractions of Candida albicans showed the presence of anti-C. albicans antibodies, detected by the gel-immunodiffusion, agglutination and immune adherence tests.
Agglutination Tests↗
Canaliculitis with isolation of Pityrosporum pachydermatis.
A case of canaliculitis with obstruction of the lacrimal canaliculus and accumulation of conglomerates is described. Pityrosporum pachydermatis was cultured from the conglomerates. To the best of our knowledge this organism has not been previously implicated in such infections. Cure was obtained by treatment with nystatin administered topically and as an irrigation of the lacrimal pathways. The possibility that the pathogenesis of the canaliculitis and obstruction of the lacrimal pathways lies in decreased function of the lacrimal pump is discussed.
Dacryocystitis↗
[Unusual acute lymphoblastic leukemia in an elderly patient].
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Aged↗