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Biomedical subjects

E Schippers

Publications and source records attributed to E Schippers.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Gastroesophageal reflux--surgical indications, laparoscopic surgical technique, results].

OBJECTIVE: To investigate criteria for indication to surgery and results of laparoscopic fundoplication. BACKGROUND: Gastroesophageal reflux is a common problem in well developed countries. Beside clinical symptoms of heartburn and regurgitation complications may occur like esophagitis, bleeding, ulceration, mucosal metaplasia and loss of motility. A connection of reflux disease, Barrett's esophagus and adenocarcinoma of motility. A connection of reflux disease, Barrett's esophagus and adenocarcinoma of the esophagogastric junction is discussed. In some patients medical treatment is complicated by relapse, persistent or progressive disease. For these patients laparoscopic antireflux surgery may be an effective alternative. PATIENTS: 22 patients with chronic gastroesophageal reflux disease. METHODS: Since 9-2-1922 patients with gastroesophageal reflux disease were prospectively evaluated and treated by laparoscopic Nissen fundoplication. RESULTS: 11 patients had frequent recurrent disease, 9 persistent reflux and 2 a stricture while on medical treatment. All had pathologic reflux on 24 hour pH monitoring and defective sphincter on standard manometry. Beside an intraoperative pneumothorax there was no intraoperative complication. Postoperative 2 patients had a temporary and 1 mild persisted dysphagia. None had recurrent reflux. 10 patients were reevaluated one year after surgery. None had an esophagitis, abnormal reflux or an insufficient or hypercontinent sphincter. CONCLUSIONS: Patients with recurrent or persistent reflux while on medical treatment with abnormal reflux on pH monitoring and defective sphincter on manometry can be treated by laparoscopic Nissen fundoplication with good results.

Adult↗
PubMed1996

[Pro-Shouldice: primary tension-free hernia repair--conditio sine qua non?].

Protagonists of laparoscopic hernia repair with mesh emphasize the tension-free repair as a main advantage. Thus, conventional techniques of hernia repair with tissue approximation and suture lines are questioned. Postulated advantages of the tension-free repair are less postoperative pain, shorter labour disability, less recurrences and less complications. The results of our own patients (primary hernia n = 2025, recurrent hernias n = 897) operated with the Shouldice technique were evaluated with regard to the postulated advantages of the tension-free repair. 95% of our patients were operated under local anesthesia. The amount of analgetic drugs/patient decreased from 45% first postoperative day to 20% second postoperative day. The individual judgement of pain with a visual analogue scale decreased to zero at the second postoperative day. Chronic groin pain persisted in 1.4% after primary hernia repair and 2.6% after repair of recurrent hernias in our patients. Mobilizing the patient from the operating table the postoperative hospital stay is 3,7 days after primary hernia and 6,7 days after recurrent hernia. The length of labour disability correlated significantly with the occupation. 90% of self-employees are back at work 3 weeks postoperatively while, in the group of employers, it lasts 8 weeks. 5-year follow-up reveals a recurrence rate of 1.3% after primary hernia and 3.1% after recurrent hernia. With the Shouldice repair the modern goals of hernia surgery are feasible. Therefore, a primary tension-free repair is not a "conditio sine qua non".

Anesthesia, Local↗
PubMed1996

Small intestinal myoelectrical activity and bacterial flora after Roux-en-Y reconstruction.

Small bowel myoelectrical activity and intestinal microflora were examined after partial gastrectomy and Roux-en-Y reconstruction in six dogs. Bacteriological analysis revealed a predominance of faecal bacteria. The basal electrical rhythm of the Roux limb was significantly decreased, while the frequency of phase III was increased (P < 0.05). In the bypassed duodenum, activity fronts occurred in only 25 per cent of experiments. Food intake led to an increase in the mean(s.e.m.) motility index in the Roux limb (from 46.1(9.4) to 75.0(21.5), P < 0.05), but not in the bypassed intestine (from 27.0(3.6) to 27.8(4.1), P not significant). Stimulation of the hypomotile bypassed intestine with cisapride induced an increase in the motility index from 27.0(3.6) to 111.2(16.5) (P < 0.001).

Anastomosis, Roux-en-Y↗
PubMed1996

[Minimal invasive surgery--impact on conventional surgery].

The impact of minimal invasive surgery on conventional surgery is diverse. The fields it involves include: (1) pathophysiology of surgical trauma; (2) instrumental technique; (3) medical-industrial interaction; (4) laparoscopic diagnostic procedures; (5) intraoperative endoscopy; (6) patients' comfort; (7) quality control; (8) changing hierarchy; (9) loss of surgical dogmas and (10) globalization.

Diffusion of Innovation↗
PubMed1996

[Synergistic effects of intracavitary and endoluminal endoscopic surgery].

The extended application of laparoscopic techniques led to complications related to the procedure (resection of wrong segments, non-curative resections, perforation, anastomotic stenosis/leakage). Main aetiology is the missing tactile sense. The combined action of laparoscopy and intraoperative endoluminal endoscopy is here an alternative. Intraoperative endoscopy is useful at the upper GI tract during total vagotomy, SPV, Taylor procedure, myotomy, fundoplication, perforated ulcer and BI/BII resections. During colorectal procedures, intraoperative endoscopy provides localisation of the tumor, determination of margins for resection, identification of anatomy (i.e. Hartmann stump) as well as inspection of the anastomoses. A consequent combination of intraabdominal and endoluminal endoscopy is helpful in prevention of the observed complications due to laparoscopic surgery.

Endoscopes↗
PubMed1995

Intraabdominal humidity and electromyographic activity of the gastrointestinal tract. Laparoscopy versus laparotomy.

The purpose of this study was to observe electromyographic activity of stomach, small bowel, and colon during and early after identical laparoscopic and conventional operations to compare the operative trauma. In nine dogs a cholecystectomy was performed laparoscopically (n = 5) or by laparotomy (n = 4). Analysis of electromyographic activity focused on rhythm, frequency, and amplitudes of slow waves. Furthermore, oxygenation of blood and tissue, intestinal impedance, intraabdominal humidity, and temperature were documented to investigate their influence on slow waves. Open cholecystectomy caused an evident decrease of frequency and amplitude of colonic slow waves in comparison to laparoscopic cholecystectomy. Arrhythmic slow waves were observed only in the stomach during conventional cholecystectomy. Stomach and small intestine showed no significant difference of frequency and amplitude of slow waves in both operation groups. Intraabdominal humidity and intestinal impedance differed significantly in laparoscopy and laparotomy. Laparoscopic cholecystectomy proceeded with a minor abdominal trauma documented by smaller alterations of slow waves. This may be caused by reduced peritoneal desiccation.

Animals↗
PubMed1994

[Laparoscopy versus laparotomy. An animal experiment study comparing adhesion formation in the dog].

We performed laparoscopy (n = 7) or laparotomy (n = 7) for exploration of the small intestine, cecal resection with Endo-GIA or TA-30, deserosation of 2 cm2 of the abdominal wall and resection of the omentum majus in dogs. After 8 days all dogs were re-examined and the adhesions were quantified by computer-aided measurement. Laparoscopic operations were followed by significantly (P < 0.001) fewer adhesions. After conventional operations extensive adhesions to the abdominal incision and interenteric adhesions were found, together with frequent conglomerates of adhesions, intestinal kinkings or adhesive bands. Identical manipulations, such as cecal resection or deserosation of the lateral abdominal wall, led to the same frequency and severity of adhesions in both groups. Based on our results, the risk of adhesion-related complications may be reduced by the laparoscopic approach.

Abdomen↗
PubMed1994

[Motility disorders in the blind loop after Roux-en-y reconstruction. Electromyography studies in the animal experiment].

Disturbances of intestinal motility, bacterial overgrowth and pancreocibal asynchrony are frequent findings in patients after Roux-en-y reconstruction (RYR). In dogs (n = 6) electromyographic recording of motility after partial gastrectomy with Roux-en-y reconstruction revealed no significant differences from controls in the Roux limb. However, changes in intestinal motility were extensively in the blind loop. The electromyographic pattern was characterized by an extreme loss of activity in the fasted and postprandial state. The activity front of the migrating motility complex occurred only in 25% of the fasting studies and was not correlated in time with motility patterns of connected small intestine. Food intake led to a significant increase in the motility index in the Roux limb (60.2 +/- 10.5), but not in the blind ending loop (27.8 +/- 4.1). Pharmacological stimulation of the hypomotile blind loop with cisapride is successful: increase of the motility index to 111.2 +/- 16.5. It might be useful in the treatment of symptomatic patients after RYR.

Anastomosis, Roux-en-Y↗
PubMed1994

[Todani type I choledochal cyst--diagnosis and surgical therapy].

Ultrasound, ERC and computed tomography are the main preoperative diagnostic procedures of common bile duct cysts. In individual cases the definitive diagnosis can be confirmed only intraoperatively. The high rate of complications and the risk of carcinoma requires a radical surgical treatment.

Adult↗
PubMed1994

[Video thoracoscopic therapy of spontaneous pneumothorax. Technique and initial results].

The acceptance of operative therapy of spontaneous pneumothorax (SPT) has been tempered by the serious trauma of thoracotomy access. Development of videoequipment and miniaturized instruments allows now a thoracoscopic resection of bulla with minimal access. 25 patients with recurrent SPT (n = 15), primary resistant SPT (n = 5), and first SPT (n = 5) were treated from January 1991 thoracoscopically. Bullae resection was performed with an Roeder ligature or an Endo-GIA. Pleurodeses was induced by mechanical irritation or coagulation of the upper thoracic aperture with the argon beamer. Postoperative lung reinflation was rapid and without patchy collapse. The analgetic drug demand was dramatically reduced and patients were mobilised on the 1st postoperative day. Patients were discharged on the 4th postoperative day. Major complication were one hematothorax and one recurrence of SPT. The advantages of the thoracoscopic surgical treatment are rapid full expansion of the lung, decreased postoperative pain, short postoperative hospital stay and early return to normal activity.

Adult↗
PubMed1994

[Laparoscopic resection of bleeding Meckel's diverticulum].

The most malformations of the gastrointestinal tract are the Meckel's diverticula. In 25% of all complications of this disease you will find a bleeding of the diverticulum. We report a case of a 12 year old boy treated laparoscopically for a bleeding diverticulum and we describe the technical procedure. The first choice in diagnosis in the scintigraphy with 99mTc-pertechnate, at which the proof of ectop stomach mucous membrane is necessary. Laparoscopic resection of a bleeding Meckel's diverticulum performed by an experienced surgeon is a safe and considerate procedure in laparoscopic technique.

Child↗
PubMed1992

[Intestinal motility after laparoscopic vs conventional cholecystectomy. An animal experiment study and clinical observation].

First descriptions of clinical courses after laparoscopic cholecystectomy indicate a shorter period of postoperative ileus in comparison to conventional cholecystectomy. Early postoperative motility was registered in dogs (n = 10) by implanted serosal electrodes. Further on clinical signs of postoperative motility were documented in patients (n = 100) after laparoscopic and conventional cholecystectomy. In animal experiments a significantly reduced period of postoperative ileus (5.5 +/- 1 h) occurred after laparoscopic cholecystectomy in comparison with the conventional technique (46 +/- 5 h). Experimental data correlate well with earlier clinical signs of normal motility after laparoscopic cholecystectomy in patients. The shorter period of postoperative ileus is a further evidence for the minor abdominal trauma of laparoscopic techniques.

Adult↗
PubMed1992

[The effects of the carbon dioxide pneumoperitoneum in laparoscopic cholecystectomy on postoperative spontaneous respiration].

Laparoscopic cholecystectomy (LSC) is being performed increasingly often. The carbon dioxide cavity increases end-expiratory carbon dioxide (exCO2), which can be regulated by mechanical ventilation. Because about 20-40% carbon dioxide remains in the patient at the end of surgery, we were interested in its influence on spontaneous respiration. PATIENTS AND METHODS. Fifteen patients classed as ASA 1-2 and undergoing LSC were compared with 15 patients (also ASA 1-2) undergoing laparotomy for cholecystectomy (LAP). All patients had balanced anaesthesia with fentanyl, enflurane, nitrous oxide and vecuronium. After surgery they were extubated when spontaneous respiration and vigilance were adequate. In the next 3 h we continuously determined exCO2 in the expired air through an intranasal catheter, and oxygen saturation (SAT), respiratory rate (RR) and heart rate (HR) using Oscar (Datex) and Ohmeda (Braun) apparatus while the patients were breathing room air. The blood pressure (BP) was determined intermittently. Postoperative pain treatment was standardized. RESULTS. The groups were reduced comparable with respect of the anthropometric data, because the weight was significantly higher in the LAP group. Fentanyl consumption was also significantly higher in the LAP group, reflecting the more pronounced trauma than with LSC. Mean exCO2 was 46 mmHg after LSC and 36 mmHg after LAP (P less than or equal to 0.05), continuously decreasing in the LSC group and increasing in the LAP group to 40 mmHg after 3 h. Mean RR was 18-20.min-1 after LSC and 12-15.min-1 after LAP during this period (P less than or equal to 0.05). There were no differences in SAT (94-96%), HR (75.min-1) and BP (130/80 mmHg). DISCUSSION AND CONCLUSIONS. The remaining carbon dioxide after LSC has important implications for postoperative spontaneous respiration. Probably due to an activation of carbon dioxide receptors, RR is increased to eliminate residual carbon dioxide. This is confirmed by a significantly increased exCO2 compared with that in the LAP group. This effect lasts at least 3 h, exCO2 being comparable in both groups, but RR is still increased after LSC. This different respiratory pattern does not affect SAT, being normal without hypoxic episodes. Cardiovascular parameters were also normal without group differences. We conclude that the carbon dioxide peritoneal cavity has important consequences for postoperative ventilation. Using our anaesthetic technique and postoperative treatment exCO2 reaches normal values after about 3 h due to an increased RR. If other methods, e.g., stronger opioids, which decrease carbon dioxide response are used, this effect may even be prolonged and more pronounced. We are now performing an investigation to evaluate this effect.

Adult↗
PubMed1992

[Rectal cancer--results of continence-preserving resections].

In a series of 586 patients with rectal carcinoma who underwent potentially curative resection between January 1977 and December 1990 postoperative complications, incidence of local recurrence and disease free survival are investigated. Of the 401 patients undergoing low anterior resection (LAR) and 89 patients with coloanal anastomosis (CAA) 389 anastomoses were fashioned with staples. The hospital mortality rate was 4.6%. Clinical anastomotic leakage occurred in 5.5% (handsewn 10.3% stapled 4.3% (p less than 0.05), anastomotic strictures in 7.5% and 2.4% (p less than 0.05). 20% of patients undergoing restaurative resection (RR) (handsewn 23%, stapled 20%) developed local recurrences compared with 21% for the group with abdominoperineal resection (APR). The corrected 5-year survival rate was 63% for RR respectively 55% for APR (p greater than 0.05). After CAA, incidence of local recurrence and survival rate for patients with carcinoma of the lower rectum was 11% respectively 63%. It is concluded that innovative advances like the development of circular stapling devices and the adoption of a more aggressive sphincter-saving policy like CAA cause not an increased risk of recurrent diseases and no decrease of the 5-year survival rate.

Adult↗
PubMed1991

Return of interdigestive motor complex after abdominal surgery. End of postoperative ileus?

Gastrointestinal mechanical activity was studied in 13 patients after different surgical procedures in a fasted and fed state and after pharmacological stimulation. Mechanical activity was recorded by means of a multi-pressure sensor probe placed intraoperatively into the jejunum. Abdominal surgery abolished normal motility only for a short period of time. The time for the reappearance of regular recurring activity fronts varied with the type of the surgical procedure from 3 hr after cholecystectomy to the sixth postoperative day after colon resection. The fed pattern occurred after the first postoperative interdigestive motor complex in all experiments. Stimulation was observed with ceruletide, which induced contractile activity in the small intestine during postoperative ileus. No coordinated caudad propagating activity was observed. The postoperative interdigestive motor complex did not correlate in time with the first passage of flatus and stool in our patients. Thus, the restoration of motility in the small intestine did not coincide with the clinical relief from the so-called "physiological" postoperative ileus.

Aged↗