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Biomedical subjects

E Scherfig

Publications and source records attributed to E Scherfig.

30 records · Page 2Linked to original sources

Trilateral malignant lymphoma: primary malignant B-cell lymphoma of the eyes and brain. Diagnosis by transvitreal retinochoroidal biopsy.

A 59-year-old woman with therapy-resistant bilateral involvement of posterior uvea and retina of some months' duration was examined. Diagnostic vitrectomy was inconclusive, but subsequent transvitreal retinochoroidal biopsy gave ample material for the immunohistopathological diagnosis of a malignant B cell lymphoma. Despite systemic and intrathecal cytostatics and ocular X-ray therapy, central nervous system involvement was observed 2 months later. The ocular lesions regressed after treatment and have not recurred.

B-Lymphocytes↗

Treatment of senile macular degeneration by laser photocoagulation.

117 eyes of 103 patients among 476 patients with senile macular degeneration fulfilled a criterion for treatment with blue-green Argon (n = 20 eyes), green Argon (n = 15 eyes) Krypton-red (n = 58 eyes) and combined treatment (24 eyes). In 50 consecutive treated eyes (= 50 patients) with an observation time exceeding one year a visual acuity greater than or equal to 6/18 was preserved in 34 eyes. This post-laser course differs from the spontaneous course of the disease reported in literature indicating that about 70% of eyes with perifoveal neovascular lesion will develop legal blindness within 2 years. Even though the spontaneous course in this material is unknown, and the comparability to patient material in literature is questionable, it might be concluded that a considerable part of the patients with senile macular degeneration with neovascular lesions might benefit from laser-treatment.

Aged↗

Flash visual evoked potential as a prognostic factor for vitreous operations in diabetic eyes.

In 116 diabetic eyes scheduled for vitreous surgery, the visual evoked potential (VEP) after flash stimulation was recorded prior to surgery. Latencies of the flash evoked potentials show a distribution suggestive of a Gaussian curve with an abnormal extension. Dividing the material into two groups based on a latency shorter or longer than 100 milliseconds revealed a highly significant difference in the visual improvement following surgery between patients with a short and patients with a long latency (P less than 0.001). With a latency longer than 100 millisec. most patients showed no visual change after operation, and among the few who did the change, consisted more often in visual reduction than improvement. Additional investigations in the study reveal that it is likely that the prolonged latency of the flash VEP is due to pathology of the retina or visual pathways.

Diabetic Retinopathy↗

Visual evoked potential as a prognostic factor for vitrectomy in diabetic eyes.

To determine whether or not the electrophysiological status of the eye can give information as to the result of vitreous surgery, the visual evoked potential to flash stimulation was measured prior to vitreous surgery. Seventy-four eyes were submitted to surgery. Latencies of flash evoked potentials showed a distribution suggestive of a Gaussian curve with an abnormal extension. Dividing the material into 2 groups based on a latency longer or shorter than 100 millisec revealed a highly significant difference in visual improvement after surgery between patients with long latency and patients with short latency (P less than 0.001). With a latency longer than 100 millisec the patient has an almost equal chance of visual improvement or visual reduction by surgery. The frequency of operative complications was twice as high in patients with latency longer than 100 millisec compared to patients with a latency shorter than 100 millisec.

Diabetic Retinopathy↗

Prognostic parameters in pars plana vitrectomy.

Based on a period of introduction with the vitrectomy technic the visual acuity results in 143 consecutive cases performed between 1976 and 1980 are related to the anamnestic information, the pre-, per- and post-operative findings. In this introductional period the patients referred had longstanding retinovitreal changes, and, because of lack of prognostic parameters, all patients were offered surgery regardless of the observed pathology. All vitrectomies were carried out with the Klöti macrostripper and diathermy unit, without any additional instrumentation. From the results of these early cases, we have changed our surgical method to a three-port entrance with a separate infusion canula, a separate fiberoptic illumination and an interchange between vitrector, automatic scissors, hook, stilleto, vacuo needle, forceps and intravitreous photocoagulation through a third port. Diabetics should be offered vitrectomy if vitreous haemorrhages last for more than 3 months. Vitrectomy is considered useless or contraindicated in diabetics with lack of light perception or light projection, neovascular glaucoma, extinguished visual evoked potential. Only an improvement in the peripheral vision can be expected in diabetics with macular detachment. In rhegmatogenous detachment cases with intravitreal traction, vitreous operations should be performed only where intraretinal or retroretinal changes do not prevent mobilization or unfolding of the retina. Traumatic vitreoretinal disorders should be operated upon early.

Adolescent↗

A pressure pulse amplitude lowering effect of retinal xenon photocoagulation in normotensive diabetic eyes.

In 20 diabetic patients with normal intraocular pressures (IOP) the effect of monocular panretinal xenon photocoagulation of intraocular pressure pulse amplitudes (IOPA) was recorded with the applanating suction cup applied bilaterally. One month after the treatment the photocoagulated eye showed an average decrease in IOPA of 32% which was statistically significant when compared to the untreated fellow eye. The decrease was greater than expected from the simultaneous fall in IOP, this indicated that the photocoagulations affected the vascularity of the choroid. The ocular rigidity was unchanged.

Adult↗

A pressure lowering effect of retinal xenon photocoagulation in normotensive diabetic eyes.

In 10 diabetic patients with normal intraocular pressures, the effect of monocular panretinal xenon photocoagulation was recorded with the applanating suction cup tonograph applied bilaterally. One month after the treatment, the photocoagulated eyes showed an average decrease in pressure of approximately 3 mmHg, which was statistically significant (P < 0.001) when compared to the untreated fellow eye. On a percentage basis the falls were of a similar magnitude (approximately 25%) as those observed by others after photocoagulation in neovascular glaucoma.

Adult↗

Direct ophthalmoscopy with simultaneous colour television transmission.

The authors have developed a direct ophthalmoscope with simultaneous television transmission. The ophthalmoscope is used clinically for student as well as postgraduate teaching and for intercollegial discussion of retinal changes which give rise to differential diagnostic difficulties.

Diagnosis, Differential↗