Search PubMed⌕ Search

Biomedical subjects

E Schaefer

Publications and source records attributed to E Schaefer.

At least 37 records · Page 2Linked to original sources
PubMed1988

Doppler echocardiographic assessment of left ventricular filling dynamics in patients with coronary heart disease and normal systolic function.

The purpose of this study was to assess altered left ventricular diastolic filling by noninvasive means in patients with coronary artery disease and normal systolic pump function. Mitral inflow velocity was measured by pulsed Doppler, and left ventricular volumes were obtained from cross-sectional echocardiography at rest and during upright bicycle exercise. Peak and integrated early and late diastolic filling velocities were calculated from Doppler-derived time-velocity curves. Studies were performed in normal subjects (group I, n = 8) and in patients with angiographically proven coronary artery disease (Group II, n = 18). The ejection fraction was not significantly different in group II as compared to group I (group I, 60 +/- 7%; group II, 55 +/- 11%). During exercise, ejection fraction increased significantly in group I by 7.6%, but did not increase in group II. In all cases, diastolic filling showed a biphasic pattern. At rest, the major part of diastolic filling occurred during early diastole: the ratio of early filling velocity integral (E) to the late filling velocity integral (L) was significantly greater in group I than in group II (group I, 1.74 +/- 37; group II, 1.19 +/- 3, P less than 0.001). During exercise, early diastolic filling was unchanged in normal subjects but decreased in patients, with a significant decrease in E/L index of 34% (P less than 0.001). Thus, pulsed Doppler echocardiography provides a useful method for assessing noninvasively exercise-induced changes in left ventricular diastolic filling dynamics in patients with coronary artery disease.

Adult↗
PubMed1988

[Noninvasive determination of left ventricular diastolic filling parameters using Doppler echocardiography: clinical application in patients with coronary heart disease].

The purpose of this study was to characterize noninvasively left ventricular diastolic filling in patients with coronary artery disease (CAD), by the use of pulsed Dopplerecho. 139 consecutive patients with CAD (with myocardial infarction, MI, n = 110; without MI, n = 29) were included in the study and compared to 67 normal subjects. Analyzing age-matched subgroups, patients with CAD and MI showed a significantly lower peak early diastolic filling velocity (R) as compared to normal subjects. The ratio (E/L) of early (E) to late (L) filling velocity integral as well as the ratio of peak early (R) to peak late (A) filling velocity were significantly lower in patients with MI than in normal subjects. Furthermore, A was lower in patients with MI, as compared to patients without MI. There were no significant differences between patients with single-vessel and multi-vessel disease. The ejection fraction was not significantly related to the diastolic filling parameters. In the normal population (aged 15-66 years) all diastolic filling parameters tested showed a significant correlation with age. The best correlation was found with the E/L ratio (r = -0.63, p less than 0.001). In contrast, there was no significant correlation between age and any of the diastolic filling parameters in patients with CAD. In patients with MI and left ventricular enddiastolic pressure (LVEDP) greater than or equal to 20 mm Hg, E/L was within normal limits, however, and was higher than in patients with LVEDP less than or equal to 14 mm Hg (LVEDP greater than or equal to 20 mm Hg: 2.1 +/- 1.5 SD vs. LVEDP less than or equal to 14 mm Hg: 1.09 +/- 0.38 SD, p less than 0.003).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1987

[Cerebro-costo-mandibular syndrome without cerebral involvement in a 4-year-old boy].

In a four year old boy the combination of Robin sequence and multiple dorsal rib defects on the first day of life could be classified as cerebro-costo-mandibular syndrome. In contrast to an unfavorable clinical course with cerebral involvement which has repeatedly been observed, in our patient psychomotor development has been normal so far. A brief literature review of a total of 36 patients shows that despite a unfavorable prognosis quoad vitam, roughly half the patients have survived. Half of the surviving patients showed functional disorders of the central nervous system, and only one third was mentally retarded. The favorable clinical course documented here thus supports the hypothesis that cerebral symptoms are not an obligatory component of the syndrome, but are only to be regarded as a facultative risk in the "costo-mandibular" syndrome. Accordingly, therapeutic nihilism does not seem to be justified. The etiology of the cerebro-costo-mandibular syndrome could not be clarified unequivocally up to now. A series of family observations indicate a monogenic cause, but genetic heterogeneity can not be ruled out.

Child, Preschool↗
PubMed1986

[Coffin-Siris syndrome in a 5-year-old girl].

A 5 1/2 year old female patient with Coffin-Siris syndrome is described. This syndrome is characterised by multiple congenital anomalies and mental retardation. The important clinical features include postnatal growth retardation, microcephaly, considerable psychomotor retardation, coarse facies with thick lips, sparse scalp hair with hypertrichosis of the face and body, as well as hypoplasia or even aplasia of distal phalanges of fingers and toes. Chromosomal aberrations, which could be considered as differential diagnosis are excluded by the finding of a normal karyotype. The aetiology or pathogenesis of this syndrome are not really known.

Abnormalities, Multiple↗
PubMed1985

[Traumatic pancreatitis with peripheral osteolysis suggesting child abuse].

In a nine year old girl pancreatitis was suspected after roentgenologic demonstration of osteolytic lesions in the short bones of her hands and feet. Similar to the 18 cases found in the literature she had upper abdominal trauma in her history, and as in 6 other cases there was a history of child abuse and battering. There was complete remission of the lesions following operation of the pancreatic pseudocyst. In this disease pseudocysts develop very often, they were found in 12 of the 18 cases reported. There is no valid explanation of the pathogenetic mechanism leading to osteolytic lesions. Intracapillary coagulation might contribute to the development of necrotic areas in the bone. It is concluded that especially in patients with only slight upper abdominal pain roentgenologic examination of part of the skeleton might be helpful in establishing the diagnosis.

Abdominal Injuries↗
PubMed1983

The Weaver syndrome in a girl.

This paper reports the first female case of the Weaver syndrome. The prominent clinical features are gigantism, macrocephaly, and the characteristic facial dysmorphism. Hypertonia and bone maturation acceleration are somewhat less pronounced than in the formerly published cases of male patients. The etiology of the syndrome remains unclear, but if genetic, X-linked recessive inheritance can be excluded.

Bone Development↗
PubMed1980

Mesomelic dysplasia with short ulna, long fibula, brachymetacarpy, and micrognathia. Clinical and radiological differential diagnostic features.

A girl with a "new" variant of mesomelic dysplasia is reported. The disorder is characterized by mesomelic brachymely, especially of the arms, a short ulna, relatively long fibula, brachymetacarpy, minor symmetrical changes at the hands, developmental arrest of the spine, contractures, and micrognathia. The clinical and radiological differential diagnostic features are discussed.

Bone Diseases, Developmental↗
PubMed1980

[Intussusception in the newborn (author's transl)].

A five day old male neonate had bloody stools and decreasing appetite. He was subjected to laparotomy after x-ray investigations had shown an intussusception. This was due to a cystic duplication of the ileum just before the ileocecal valve. After an ileocecal resection the postoperative course was uneventful. Special problems of the intussusception in the newborn are discussed.

Humans↗