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Biomedical subjects

E Scapa

Publications and source records attributed to E Scapa.

87 records · Page 5Linked to original sources
PubMed1982

[Ventral pancreas].

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Diagnosis, Differential↗
PubMed1981

Effect of N-methylpyridinium-2-aldoxime methane sulphonate (P2S) on rat intestinal, (Na-K)ATPase and adenyl cyclase activities.

The effect of N-methylpyridinium-2-aldoxime methane sulphonate (P2S), a drug recommended for prophylactic and therapeutic purposes in organophosphate poisoning, on intestinal (Na-K) ATPase and adenyl cyclase activities, was tested in rats. Intestinal (Na-K) ATPase activity was determined 5 h after intragastric administration of either 0.15 M NaCl or P2S 200 mg/kg body weight. P2S decreased significantly jejunal and colonic (Na-K)ATPase activity, 17.1 +/- 4.8 (S.E.) and 13.5 +/- 3.0, as compared to that in saline-treated rats, 41.5 +/- 3.0 (S.E.) and 25.4 +/- 1.2 mumol Pi/mg protein per h, respectively. Pretreatment with methyl prednisolone did not prevent the decrease in enzyme activity induced by P2S. Mucosal PGE2 and cAMP contents, adenyl cyclase and phosphodiesterase activities, were similar in P2S and saline-treated rats. It is thus suggested that P2S-induced inhibition of intestinal (Na-K)ATPase activity might be among the mechanisms contributing to looseness of the stool frequently observed following P2S administration.

Adenylyl Cyclases↗
PubMed1981

Prolonged opacification of the gallbladder after oral cholecystography: a reevaluation of its clinical significance.

The frequency of prolonged opacification of the gallbladder after oral cholecystography was determined in several conditions that are manifestly or reputedly associated with gallbladder dysfunction: in patients with gallstones, in cases of "biliary colic" with normal cholecystograms, in postvagotomy patients, and in diabetics. These groups were compared with asymptomatic controls and to patients with irritable bowel syndrome. A dietary fat intake of at least 50 g between the first and last films taken was ensured in all subjects. The effect of fat deprivation was separately studied in asymptomatic controls. Prolonged opacification was encountered in approximately two-thirds of patients with gallstones, in two-thirds of patients with "acalculous biliary colic," in two-thirds of healthy subjects deprived of fat, and in about one-third of postvagotomy patients and diabetics. It was not seen in a single patient with irritable bowel syndrome, and it was encountered in only 1 out of 17 controls whose diet included a fat supplement. These differences were highly significant (p less than 0.0001).

Adult↗
PubMed1979

[Whipple's disease].

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Anti-Bacterial Agents↗
PubMed1979

Anuria in childhood due to bilateral urolithiasis. A report of four cases.

Four children with anuria due to occlusion of both ureters by calculi are presented. A plain film of the abdomen revealed faintly radiopaque urinary calculi bilaterally in three patients. In the fourth case, one calculus was visualized in the right ureter, but further contralateral exploration showed an obstructing ureteral calculus in the left ureter as well. It is concluded that in children with acute anuria, the possibility of bilateral ureteral obstruction due to calculi should be the physician's first consideration.

Acute Disease↗
PubMedDate not supplied

Does laparoscopic cholecystectomy influence peri-sinusoidal cell activity?

BACKGROUND/AIMS: To investigate the influence of laparoscopic procedures on perisinusoidal cell function. METHODOLOGY: In 31 patients who underwent laparoscopic cholecystectomy for symptomatic cholelithiasis, the serum levels of beta-N-acetyl hexosaminidase (beta-NAH) and hyaluronic acid (HA) were measured. Six female patients, who underwent other laparoscopic procedures, not involving the hepatobiliary system, served as controls. RESULTS: HA serum levels increased significantly in both study and control groups, while beta-NAH serum levels remained within normal values. Post-operative AST and ALT serum levels increased significantly only in the study group. No elevation of serum ALP was noted in any of our patients, and post-operative bilirubin levels did not increase in patients with normal pre-operative levels. CONCLUSIONS: Laparoscopic procedures caused detectable damage to Kupffer and endothelial cells as reflected by elevation of post-operative HA serum levels. The damage to the liver hepatocytes and perisinusoidal cells has no clinical significance and the laparoscopic procedure itself is the probable cause of the Kupffer and endothelial cells damage, while other mechanisms caused damage to the hepatocytes.

Adult↗
PubMedDate not supplied

Elevated carcinoembryonic antigen (CEA) levels in a patient with no malignancy.

Carcinoembryonic antigen rarely exceeds serum levels of 10-12 ng/mL in benign diseases and has never been found above 24 ng/ml. We report a case in which carcinoembryonic antigen serum levels reached the value of 44.9 ng/ml without any overt reason (after 22 months of follow-up). A decline of the carcinoembryonic antigen to normal ranges was noticed after a radiolabeled anti-carcinoembryonic antigen monoclonal antibody scan was performed. The reason for this phenomenon is unclear.

Aged↗
PubMedDate not supplied

Does general anesthesia affect sinusoidal liver cells as measured by beta-N-acetyl hexosaminidase serum activity level?

BACKGROUND/AIMS: General anesthesia causes temporary hypoxia of liver tissue, resulting in several metabolic changes. The purpose of this study was to explore whether the function of hepatic sinusoidal cells, especially the Kupffer and endothelial cells, are damaged following general anesthesia. METHODOLOGY: Liver sinusoidal cell (LSC) function was evaluated by means of measuring the serum level of activity of the lysosomal hydrolase beta-N-acetyl hexosaminidase before and 24 hours after general anesthesia in 20 patients who underwent orthopedic surgery. RESULTS: The only change in liver function which might be of clinical significance was a mild decline in the serum albumin level. CONCLUSIONS: Liver sinusoidal cells, especially Kupffer and endothelial cells, most probably remain undamaged after 1 to 5 hours of general anesthesia.

Adolescent↗