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Biomedical subjects

E Sanz

Publications and source records attributed to E Sanz.

At least 91 records · Page 5Linked to original sources
PubMed1985

Influence of plasma renin content, intrarenal angiotensin II, captopril, and calcium channel blockers on the vasoconstriction and renin release promoted by adenosine in the kidney.

Our study was undertaken to assess whether the effect of intrarenal infusion of adenosine on renal blood flow and renin release in dogs is modified by the degree of stimulation of the intrarenal renin-angiotensin system. This system was modified by sodium deprivation, extracellular volume expansion, beta-adrenergic blockade and stimulation, angiotensin II infusion, and inhibition of converting enzyme by captopril. In addition, the effect of blocking slow calcium channels with verapamil on the vasoconstrictor effect of adenosine was also studied. Results demonstrate that the vasoconstrictor effect of adenosine was not modified by the status of stimulation or inhibition of the renin-angiotensin system or by the status of expansion of the extracellular volume. In all cases adenosine inhibited the renal secretion of renin. Verapamil abolished the vascular actions of adenosine, but it had no effect on the inhibition of renin release. We conclude that plasma renin or angiotensin II levels are not a necessary determinant of the renal vasoconstriction induced by adenosine. This effect seems to be mediated by the entry of calcium into the cell.

Adenosine↗
PubMed1984

Surgical repair of double-outlet right atrium.

The case of a patient with abnormal position of the atrial septum resulting in a right atrium with two atrioventricular valves and a disconnected left atrium is presented. The left superior vena cava drained into the left atrium; the right superior vena cava and the coronary sinus were absent. The surgical technique for repair of this anomaly is described. A possible explanation of the embryopathogenesis of double-outlet right atrium is given. To our knowledge, this is the second case of double-outlet right atrium to be reported in the thoracic surgical literature.

Cardiopulmonary Bypass↗
PubMed1983

Cardiogoniometry.

Cardiogoniometry is a new method to test heart function. It consists of a simple computerized vectorcardiography with a system of leads derived for the construction of three orthogonal projections. With the aid of these three-dimensional projections the cardiogoniometer, a microprocessor system, measures and computes the maximal vectors of depolarization (QRS) and repolarization (T). It also fixes the orientation of these two spatial vectors by projection on two planes (frontal and oblique sagittal) and determines the solid angle phi between them. Every third heart beat these five parameters and the preceding beat interval are printed out. In this way, a series of measurements is obtained in which only little disturbances of the signals of cardiac de- and repolarization occur. In patients with latent coronary insufficiency an abnormal position of the T vector can be detected long before the standard ECG shows a pathological pattern. Cardiogoniometry can be performed in the consulting room or at the bedside. It is noninvasive, painless, and free of risk. The value and limits of this new method are to be tested in comparison with the ECG and invasive methods in cardiology laboratories.

Adolescent↗
PubMed1983

Cardiogoniometry: a new noninvasive method for detection of ischemic heart disease.

Cardiogoniometry is a new vectorcardiographic method. The vector-loops are constructed from three orthogonal ECG leads and registered on-line by a microprocessor. The angle between the maximal QRS and T vectors, as well as the spatial orientation of these vectors are very constant in healthy individuals. Deviations of these vectors and angles are sensitive indicators for changes in repolarization occurring, for instance, during coronary insufficiency. The changes in these variables were evaluated in 50 patients with suspected coronary artery disease and correlated with angiographic findings. Cardiogoniometry showed a sensitivity of 79% and a specificity of 82%, which is comparable to exercise testing. In contrast to the latter cardiogoniometry can be performed at rest, is free of risk, and therefore also suitable for elderly patients.

Computers↗
PubMed1975

[Proceedings: The specific ECG of the mesosystolic click-telesystolic murmur syndrome (So-called subvalvular mitral insufficiency). Zäziwil study. III].

For the diagnosis of small ischemic areas of the posterior wall of the heart, and particularly in the papillary muscles of the left ventricle, the 12 standard leads of the ECG are insufficient. The leads of Nehb and especially the new unipolar lead a VH (of the dorsal Nehb point D but with switch scheme of Goldberger) will be found more helpful. In all 33 patients with the clinical findings of midsystolic click--late systolic murmur syndrome a negative T in lead aVH was found; only 9 patients also showed ischemic signs in lead D of Nehb and only 6 patients in standard leads as well. These findings suggest that the midsystolic click--late systolic murmur syndrome is always caused by a papillary muscle lesion, even in young patients. A negative T in lead aVH (isolated or combined with signs of ischemic alterations on other leads) appears to point to the existence of a papillary muscle defect, even with a normal auscultatory finding. In this case the lesion will be too small to cause papillary muscle dysfunction. Usually, however, the typical auscultatory finding will be subvalvular mitral insufficiency (i.e. midsystolic click--late systolic murmur or a murmur called "pa-futt" by Huchard, in our opinion the same finding). In view of the fact that papillary muscles are vascularized by the finest ends of the coronary arteries, it seems obvious that a negative T in lead aVH could also signify the beginning of coronary heart disease.

Electrocardiography↗