Biomedical subjects

E Santoro

Publications and source records attributed to E Santoro.

129 records · Page 8Linked to original sources

PubMedDate not supplied

Enoxaparin in the prevention of deep venous thrombosis after major surgery: multicentric study. The Italian Study Group.

DVT is a very frequent complication of general surgery. Heparin and, more recently, LMWHs can successfully prevent post surgical thromboembolism. One thousand one hundred and twenty-two patients (533 males and 589 females; mean age 62.2 +/- 11.4 yrs) were enrolled in a multicentre controlled study, to evaluate the efficacy and safety of enoxaparin in comparison to calcium heparin in the prevention of deep venous thrombosis (DVT) following general surgery. Patients assigned to the enoxaparin and the calcium heparin groups received 1 daily dose of 20 mg (2000 I.U.) and 2 daily doses of 0.2 ml (5000 I.U.), respectively starting 2 hours before the operation. Both drugs were given by subcutaneous route. A Doppler or Duplex Scan diagnosis of DVT was made in 3 (0.5%) patients in the enoxaparin group (2 cases during treatment and 1 patient at the end of treatment) and in 6 (1.1%) patients in the calcium heparin group (5 cases during treatment and 1, bilateral, after the end of treatment). Pulmonary embolism (PE) was ascertained by angiography in 1 patient (0.18%) in the enoxaparin group and in 2 patients (0.36%) in the calcium heparin one. Hemorrhagic complications occurred in 29 patients (5.2%) in the enoxaparin group and in 34 (6.1%) in the calcium heparin group. Haematomas located in the injection site were reported in 16.1% and 25.3% in the enoxaparin and calcium heparin groups respectively (p = 0.0001). Local pain in the injection site at the 5th day of treatment was reported in 8.4% and 16.6% in the enoxaparin and calcium heparin groups respectively (p = 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

PubMedDate not supplied

DNA ploidy, proliferative index and EGF-R status in 130 cases of resected gastric cancer--a multivariate analysis.

BACKGROUND/AIMS: The purpose of this study was to define the prognostic role of DNA ploidy, proliferative index and EGF-R status in resected gastric cancer. MATERIALS AND METHODS: Ten clinico-pathological parameters and three biological factors obtained from flow cytometry and immunohisto-chemistry were evaluated in a series of 130 gastric cancer patients who received surgical treatment, including 28 stage IV cases (21.6%), using paraffin-embedded and fresh specimens in 77.7% and 22.3% of the cases, respectively. These variables were first analyzed and tested for correlation within the whole series and then weighted against survival in 117 applicable cases through univariate and multivariate analyses. RESULTS: Aneuploidy was significantly related to higher proliferative activity, EGF-R expression and deeper stomach wall infiltration. Higher proliferative activity was significantly related to deeper stomach wall infiltration and larger tumor diameter. The latter showed a significant relationship to EGF-R expression. Univariate analysis showed the significant variables for survival to be DNA ploidy, pT, pN, M, stage, histological type according to Lauren and tumor diameter. Multivariate analysis calculated on these significant variables using the Cox multiple stepwise regression model detected three factors which independently influence survival: pathological stage (p < 0.00001), histological type according to Lauren (p < 0.002) and DNA ploidy (p < 0.03). CONCLUSIONS: DNA ploidy was shown to be a significant prognostic parameter in resected gastric cancer after pathological stage and histological type according to Lauren. The prognostic roles of proliferative activity and EGF-R status require further investigation.

Adenocarcinoma↗

PubMedDate not supplied

Primary adenocarcinoma of the duodenum: treatment and survival in 89 patients.

BACKGROUND/AIMS: Primary adenocarcinoma of the duodenum is a rare disease and diagnosis is always late in being confirmed because of the non-specific symptoms, consequently leading to poor prognosis. METHODOLOGY: A retrospective review of 89 patients with non-ampullary duodenal adenocarcinoma treated in 36 different surgical departments in Italy between 1980 and 1994 was performed. The signs and symptoms, diagnostic studies conducted, tumor locations, surgical treatment, and survival were analyzed. RESULTS: Duodenography and endoscopy were the most effective diagnostic tests, showing an accuracy of 81.9% and 88%, respectively. The most common tumor site was periampullary, observed in 62.9% of the cases. A curative resection was performed in 65 of the 89 patients (73%), a partial pancreatoduodenectomy in 37, a segmentary duodenal resection in 15 and a wide local excision in 11. The postoperative mortality rate was 10.1% (9 patients), and the overall 5-year survival was 25%, which was significantly better after resection. The most important prognostic factors were stage and tumor location. CONCLUSION: Early diagnosis of primary duodenal adenocarcinoma is the only way to improve the results, by providing a higher resectability rate.

Adenocarcinoma↗