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Biomedical subjects

E Sander

Publications and source records attributed to E Sander.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Fracture of the tibial shaft--still a traumatology problem?].

Diaphyseal fractures of the lower leg have continued to hold a special position in terms of incidence, type, severity, and frequency of typical complications as well as healing disorders. Despite general consensus regarding fracture healing and major factors of influence, there still is discrepancy of opinions and recommendations, in the context of pathophysiology, mechanics, and therapy. All in all, 302 fresh fractures and 134 cases of delayed healing or pseudoarthrosis in the diaphyseal region were treated, between 1971 and 1985. It has been the authors' experience that conservative treatment, according to the classical school, should be applied whenever possible. The trend in surgery, primarily for open fractures, is towards adequately dimensioned fixateur externe. Accurately defined minimum instability and healing with callus formation are nowadays appreciated and preferred. The fibula-ligament-membrane-complex may assume great importance to instable or defective forms of tibial fractures. Experimental and clinical investigations are likely to suggest that, depending on the individual case, the fibula should be included in the overall therapeutic concept, when it comes to impaired or delayed healing and pseudoarthrosis.

Adolescent↗
PubMed1982

Monoclonal antibodies against a plant virus.

Eight stable hybridoma clones derived from fusion of spleen cells of Tobacco Mosaic Virus (TMV) immunized mice with murine myeloma cells were grown in mass culture. They were obtained by 2 subsequent limiting dilution cloning cycles and subcultivation. Five of these clones secreted monoclonal antibodies which reacted with TMV nucleocapsid but not with capsid monomers and the monoclonal antibodies secreted by 3 other clones reacted with the TMV capsid monomer but not with the nucleocapsid. The specificity was determined by Enzyme Linked Immunosorbent Assay (ELISA) adjusted for the detection of antibodies in hybridoma culture supernatants.

Animals↗
PubMed1981

[Fatal subarachnoid hemorrhage originating from the region of the great vein of Galen following a "fight" (author's transl)].

Report of the case of a 12-year-old boy who had died due to a massive basal subarachnoid hemorrhage after moderate fight with a class mate. Findings at autopsy and by microscopic examination indicated that a lesion in the system of the great vein of Galen and the internal cerebral veins might have been the source of the bleeding. The nature of an underlying pre-existing vascular change favoring a rupture is discussed on the basis of the clinical history and the pathoanatomic findings.

Brain↗
PubMed1981

The pathology and biology of uremic pneumonitis.

Uremic pneumonitis is included in the "adult respiratory distress syndrome". Diffuse alveolo-capillary damage, interstitial and intraalveolar edema, widespread atelectases, alveolar haemorrhages and pulmonary hyaline membranes are characteristic but not pathognomonic findings in uremic pneumonitits. Investigations showed that uremic pneumonitis results from diffuse permeability disorders of the alveolo-capillary permeability combined with an intrarenal or generalized consumption of coagulation factors, and a subsequent state of hypercoagulability. A comparative morphological and clinical analysis of 66 autopsy cases with severe uremia showed that neither the intensity of the urea retention nor the intensity of the creatinine retention correlate with the morphologic symptoms of uremic pneumonitis. Uremia may induce the basic alveolocapillary damage and the subsequent plasmatic leakage into the alveoli and alveolar ducts but uremia has obviously no influence on the simultaneous formation of pulmonary hyaline membranes and intraalveolar bleedings. Hyaline membranes and intraalveolar bleedings are the entire equivalents of the immediate procoagulative activity of the underlying diseases.

Creatinine↗
PubMed1981

[Results of the operative treatment of fractures of the shaft of the femur- collective study contributed by the German Democratic Republic to the International Orthopedic Association].

The permanent increase of fractures of the shaft of the femur are due to the rising traffic density. Problems are especially arising by complicated fractures. The results of the operative treatment of these fractures in 15 clinics of the GDR are analysed. Medullary nailing is used in most cases of simple forms of fractures. Second degree and third degree open fractures should be treated by osteosynthesis or exterior fixation. (It has been proven that the early osteosynthesis performed in these patients immediately after the accident is better than the delayed one.

Accidents, Traffic↗
PubMed1979

Basement membrane thickness, insulin antibodies and HLA-antigens in long standing insulin dependent diabetics with and without severe retinopathy.

The study was designed to show whether there was any relation between muscle capillary basement membrane thickness, HLA-antigens, anti-insulin antibodies and proliferative retinopathy. Electron microscopic measurements of muscle capillary basement membrane thickness were performed on muscle biopsies from 15 insulin-dependent diabetics and severe proliferative retinopathy, 24 insulin-dependent diabetics with minimal retinopathy and 18 age- and sex matched non-diabetics. All the patients had had diabetes for 20 years or more. None had biochemical or clinical evidence of diabetic nephropathy. Basement membrane thickness was measured according to the methods of Siperstein and Williamson. Muscle capillary basement membrane thickening occurred in 32 of 39 diabetics, using the Siperstein method, but patients with proliferative retinopathy did not exhibit thicker basement membranes than patients with no or minimal changes in the retina. There were apparent differences in HLA-antigens between diabetics with and without proliferative retinopathy, but they did not reach statistical significance. There was no correlation between muscle capillary basement membrane thickness and the quantity of insulin antibodies. The results indicate that factors other than basement membrane thickening and genetic factors in the HLA-region, are responsible for the development of proliferative retinopathy.

Adult↗