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Biomedical subjects

E S V'iuchnova

Publications and source records attributed to E S V'iuchnova.

At least 19 recordsLinked to original sources
PubMed2004

[Comparative efficacy of different therapeutic schemes in gastropathies induced by nonsteroid anti-inflammatory drugs].

AIM: To study efficacy of colloid bismuth subcitrate (de-nol, Yamanuchi) in therapy of gastropathies provoked by nonsteroidal anti-inflammatory drugs (NSAID). MATERIAL AND METHODS: 63 patients (38 women and 25 men, mean age 54.2 +/- 12.8 years) with rheumatoid arthritis (n = 14), osteoarthrosis (n = 47), gouty arthritis (n = 2) regularly taking NSAID were examined. The patients were randomized into two groups. The patients of the control group 1 received therapy with omeprasol (40 mg/day), patients of group 2 were given omeprasol (40 mg/day) and de-nol (480 mg/day). RESULTS: Epithelization of erosive-ulcerous lesions were observed on the treatment day 28 in 93.9% patients of group 1 and all the patients of group 2. Normalization of the level of prostaglandin E1 by the end of the treatment was registered in 57% and 93.3% patients of groups 1 and 2, respectively. CONCLUSION: Colloid bismuth subcitrate (de-nol) effectively improves the condition of NSAID gastropathy patients, stimulates healing of erosive-ulcerous lesions of gastroduodenal zone in elevation of prostaglandins levels.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed2003

[Esomeprazole in treating duodenal ulcer in various modes of anti-Helicobacter therapy].

AIM: To assess efficiency of esomeprazole in the treatment of duodenal ulcer (DU) associated with H. pylori in various eradication regimens. MATERIAL AND METHODS: 80 patients with duodenal ulcer at least 0.5 cm in diameter were randomized into three groups. 23 patients of group 1, 28 patients of group 2 received esomeprazole for 7 days in a dose 20 mg twice a day, in a single morning dose 40 mg, respectively. 29 patients of group 3 received omeprazole 20 mg twice a day for 7 days and further 3 weeks 20 mg twice a day. All the patients were also given amoxicillin 1000 mg twice a day and clarithromycin 500 mg twice a day for a week. RESULTS: An antisecretory effect of esomeprazole as shown by 24-h monitoring of gastric secretion was longer and more stable than that of omeprazole: a latent period averaged 1.5 +/- 0.6 h in a pharmacological test with 20 mg esomeprazole, 1.2 +/- 0.4 h in intake of 40 mg esomeprazole and 2.1 +/- 0.3 h in intake of 20 mg omeprazole. Overall duration of the antisecretory effect averaged 16.8 +/- 1.9, 20.3 +/- 1.7 and 12.5 +/- 1.9 h, respectively. The time of intragastric pH > 4 was 13.1 +/- 1.6, 17.2 +/- 1.6 and 9.8 +/- 1.5 hours, respectively. Eradication of H. pylori in group 1, 2 and 3 was 91.3, 89.3 and 89.6%, respectively. Complete epithelization of ulcer occurred in 95.6, 92.8 and 93.1% cases, respectively. In 77 patients who finished the treatment according to the protocol the treatment resulted in eradication in 95.6, 92.5 and 92.8%, respectively; in epithelization--in 100, 96.3 and 96.4% patients of groups 1, 2 and 3, respectively. Side effects were mild or moderate but not causing changes of the regimen or treatment discontinuation. CONCLUSION: Esomeprazole in three-component treatment was highly effective in eradication of H. pylori and epithelisation of duodenal ulcer defects in various regimens of administration. Esomeprazole in combination with amoxicillin and clarithromycin reduces the time of treatment of DU associated with H. pylori to 1 week without further monotherapy with antisecretory drugs.

Adult↗
PubMed2002

[Chronotherapy approaches in the treatment of gastroduodenal ulcer].

Each patient with ulcer has his/her own 24-h biorhythm of acid production, features of food alkalization, duration of duodenogastric and gastroesophageal reflux. Pharmacological test conducted in prolonged 24-h pH-metry helps to select the most effective antisecretory drug, while analysis of 24-h biorhythm of acid production--optimal time for drug intake and number of its daily doses.

Anti-Ulcer Agents↗
PubMed2002

[The response to combined therapy of hepatic encephalopathy in patients with hepatic cirrhosis].

Combined therapy with gepa-merz (L-ornitine-L-aspartate) and lactulose (a synthetic disaccharide) was given to 40 patients with hepatic encephalopathy and toxic hepatic cirrhosis in decompensation. Combination of gepa-merz with lactulose was effective in the above patients. Moreover, it is an optimal one as it has a double impact on ammonia toxicity which is a basic neurotoxin in pathogenesis of hepatic encephalopathy.

Adult↗
PubMed2002

[Side effects of current anti-Helicobacter therapy].

The article deals with side effects of present-day antihelicobacter therapy including side effects of some drugs with antisecretory and antibacterial action and complications observed in using combined treatment of helicobacteriosis (triple and quadrotherapy).

Anti-Ulcer Agents↗
PubMed1995

[The correction of the hemodynamic disorders in patients with IHD complicated by intraventricular blocks by using beta-adrenergic agents].

Basing on ECG findings, the authors compare hemodynamic effects of a single dose of isadrin, obsidan and spesicor in patients with coronary heart disease complicated by bundle-branch block. Isadrin improves left ventricular contractility, reduces pulmonary hypertension and right heart overload. Obsidan and spesicor aggravate the existing hemodynamic disorders in the above patients.

Adrenergic beta-Agonists↗
PubMed1994

[Characteristics of external respiration function and pulmonary circulation in patients with ischemic heart disease complicated by disorders of intraventricular conduction].

The authors provide evidence on the condition of external respiration and hemodynamic shifts in the lesser and greater circulation in coronary patients with bundle-branch block; establish early objective quantitative criteria of the diagnosis of hemodynamic impairment arising in formation of the above blocks basing on ECG, phonocardiography, echocardiography findings; compare hemodynamic effects of single-dose nitrosorbide and corinfar in the above patients. Nitrosorbide and corinfar correct hemodynamics and external respiration, the former being more effective in normalizing the greater, while corinfar the lesser circulation.

Adult↗
PubMed1992

[Hemodynamic changes in bundle-branch block].

The paper gives the data on hemodynamic features in patients with bundle-branch block. Based on the data available in the literature, the authors outline hemodynamic abnormalities occurring in various bundle-branch blocks, mechanisms of their development, influences of hemodynamic changes occurring in the blocks on the general condition of patients.

Blood Pressure↗
PubMed1992

[Doppler echocardiographic assessment of left atrial and left ventricular function during right bundle branch block].

Electrocardiographic, echocardiographic and Doppler echocardiographic studies were performed in 44 patients with coronary heart disease and complete right bundle branch block. The patients were found to have an impaired phase pattern of left ventricular systole and diastole as more prolonged length of its isometric relaxation and contraction, lower economic feasibility and efficiency of its contraction, moderate dilation and hypertrophy. Hemodynamic abnormalities in the left heart in these patients are closely correlate with the changes in the phase pattern of right ventricular systole and they turn out to be so greater as the degree of its hypertrophy is. In complete right bundle branch block, left ventricular pump dysfunction leads to decreased cardiac output and cardiac index, increased total peripheral vascular resistance, thus predisposing to impaired greater circulation.

Adult↗
PubMed1992

[The action of the new beta-adrenoblocker Lopressor on the hemodynamics of hypertension patients].

The authors carried out a complex clinico-instrumental investigation of the effect of a new cardioselective beta-blocking agent leprozor in 116 patients with hypertensive disease (stage II). A quantitative evaluation of the hemodynamics of the left compartments of the heart with two-dimensional echocardiography was carried out. Evaluation of the efficacy of using leprozor in this category of patients was based on an analysis of the state of their hemodynamics against the background of systematic intake of the drug for 7 months. Selection of the dosage was individual under the control of circulation parameters. It is concluded that leprozor proved effective in normalization of the hemodynamics in patients with hypertensive disease.

Adult↗