Biomedical subjects

E S Falk

Publications and source records attributed to E S Falk.

76 records · Page 5Linked to original sources

PubMedDate not supplied

Use of antigenic markers and genomic fingerprinting to study epidemiology of meningococcal disease.

The usefulness of the restriction enzyme fingerprinting was investigated for epidemiological studies of meningococci isolated from three patients who fell ill in meningococcal disease within a short period of time. The strains belonged to serogroup B and had similar serotype patterns. Epidemiological connections could not be excluded but genomic fingerprinting showed that the strains were probably of different origin. It is concluded that genomic fingerprinting is a potential and sensitive tool for epidemiological studies.

Adult↗

PubMedDate not supplied

Ketotifen in the treatment of atopic dermatitis. Results of a double blind study.

In a double-blind study, half of 56 adult patients with atopic dermatitis were treated systemically for 3 months with ketotifen capsules 1 mg two times daily, while the other half was given placebo. The patients in the ketotifen group improved significantly during the treatment by all the clinical assessments. On the other hand, the patients in the placebo group were improved by only one assessment. The overall efficacy of treatment was significantly increased in the ketotifen group. No drug-related side-effects were observed.

Adolescent↗

PubMedDate not supplied

Irradiances and health risks associated with the use of UV lamps and sunbeds.

UV spectra of old sun lamps have been measured and found to contain significant amounts of UVC in addition to UVB and UVA irradiances. Their spectra are compared with that of a modern sunbed, a solar spectrum obtained with a solar elevation of 29.3 degrees and the extraterrestrial UV spectrum. The effects of UVC on human skin is rarely studied, but we know that UVB can be harmful. Old UVR lamps for cosmetic tanning irradiate significant amounts of UVB and UVC, and are therefore not recommendable. However, several action spectra indicate small health risks with limited UVA exposure, but a drastic increase in the UVA doses may be one reason for the increasing skin malignancies observed in western countries. Further research to clarify these observations has to be carried out.

Heliotherapy↗

PubMedDate not supplied

Serum alpha 2-macroglobulin levels in psoriatic patients treated with UVB and PUVA.

BACKGROUND: Abnormalities in proteinase metabolisms have been found in psoriasis and higher concentrations of neutral proteinases in psoriatic skin lesions than in unaffected skin of psoriatic patients have been observed. AIM: The aim of the study was to determine whether repeated whole body UV-(UVB and PUVA) irradiation is associated with changes in proteinase inhibitor alpha 2-macroglobulin (alpha 2-M) in patients with active plaque psoriasis. PATIENTS AND METHODS: In this study, the sera alpha 2-M levels were evaluated in cases of active plaque psoriasis before UV-, four weeks UVB (15 patients) and PUVA (11 patients) irradiation, and two weeks after completed treatment. RESULTS: Both UVB and PUVA treatment had no significant influence on alpha 2-M levels in psoriatic sera, it was, however, sufficient to treat most of the skin lesions. DISCUSSION: The beneficial effect of phototherapy in psoriasis seems not to be mediated through increased binding of proteinases by proteinases inhibitor alpha 2-M from serum.

Adult↗