Biomedical subjects

E Ryan

Publications and source records attributed to E Ryan.

At least 73 records · Page 4Linked to original sources

PubMed1987

Predictive value of CA 125 for ovarian carcinoma in patients presenting with pelvic masses.

Between November 1984 and May 1986, 56 patients presenting with a pelvic mass to the Gynecologic Oncology Service of McMaster University and the Hamilton Regional Oncology Center underwent laparotomy for possible ovarian cancer. All patients had blood drawn for CA 125 three days before operation. Levels above 35 U/mL were considered positive; CA 125 had a positive predictive value of 60%. False positives occurred in patients with nongynecologic malignancies and with benign gynecologic conditions. On the other hand, CA 125 had a negative predictive value of 100%, suggesting that this test may be useful in identifying those patients with pelvic masses at higher risk for malignancy, who may require transfer for surgery at a tertiary care center.

Adolescent↗

PubMed1985

The effects of changes in intracellular calcium on rat synaptosomal cyclic adenosine monophosphate.

Cyclic adenosine monophosphate (cAMP) concentration was measured in rat striatal and hippocampal synaptosomes. Incubation in 50 mM K+ medium caused a decrease in both striatal and hippocampal cAMP: this effect was dependent on extracellular Ca2+. Replacement of NaCl with sucrose in the incubation medium increased cAMP. Incubation with 0.5 mM ouabain was without effect.

Animals↗

PubMed1984

The effect of repeated mild stress on cerebral cortical adrenoceptors and noradrenaline synthesis in the rat.

The effects of repeated mild stress on cortical alpha 2- and beta-adrenoceptor binding sites and on the rate of noradrenaline synthesis in cortical synaptosomes were measured. The stressful stimuli were either daily handling (1 min) or daily handling which included an i.p. saline injection. In both cases, rats killed 24 h after the last of 14 daily treatments showed an increase in noradrenaline synthesis rate and a decrease of alpha 2- and beta-adrenoceptor density. There were no changes in adrenoceptor density or the noradrenaline synthesis rate after either a single or 5 daily handlings plus saline injections. At no time was a change found in the Kd of either alpha 2- or beta-adrenoceptor binding sites. The results are discussed in relation to the effects on adrenoceptors of chronic antidepressant treatments.

Animals↗

PubMed1983

Efficacy of antibiotic therapy in preventing spontaneous pregnancy loss among couples colonized with genital mycoplasmas.

Evidence suggests that genital mycoplasmas play a role in spontaneous abortion, prematurity, and perinatal morbidity and mortality rate. Since these organisms are sensitive to antibiotics, three treatment regimens were assessed for efficacy in preventing spontaneous pregnancy loss. The pregnancy loss rate was significantly reduced from 96% to 47.4% among those treated with doxycycline prior to conception and to less than 20% among those treated with erythromycin stearate only during pregnancy or with both regimens. The reduction in pregnancy loss rate was independent of maternal age, the number of previous abortions, gestational age at abortion, or other minor abnormalities. Diagnosis and treatment of mycoplasma infection following a first or later pregnancy loss equally prevented spontaneous loss in the next pregnancy. These observations suggest that appropriate treatment of mycoplasma infection could also prevent recurrent spontaneous abortion syndrome in couples with positive cultures.

Abortion, Habitual↗

PubMed1983

Serologic evidence of ureaplasma urealyticum infection in women with spontaneous pregnancy loss.

Among 71 couples with histories of pregnancy wastage, 84.5% were colonized with Ureaplasma urealyticum and/or Mycoplasma hominis; whereas in couples with successful deliveries the incidence was 25.4%. The distribution of U. urealyticum and M. hominis was comparable in the fertile and infertile populations. Of women with positive cultures, 96% aborted, compared with an expected rate of 19% to 45%. Serologic studies revealed that, at delivery, 42.9% of infants of mothers with pregnancy losses had fourfold elevations in titers above the mothers' level compared with 15% of normal infants. Mothers with pregnancy wastage histories had elevated titers above their infants in 42.9% of cases compared with 10% of normal mothers. Thus, both mothers and fetuses had responded immunologically to the presence of U. urealyticum. When the mean antibody titers in the normal and pregnancy wastage groups were calculated for each ureaplasma serotype, the infants of mothers with pregnancy losses exhibited significantly elevated mean titers to serotypes 6 and 8, while the mothers had elevated mean titers to serotypes 4 and 8. These observations suggest that U. urealyticum causes infection in mothers and fetuses and that certain ureaplasma serotypes may be more pathogenic than others.

Abortion, Spontaneous↗

PubMed1983

Antidepressant activity of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols.

A series of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols was prepared and evaluated for potential antidepressant activity in the reserpine-induced hypothermia model and selected central nervous system and autonomic activity tests. Several members of the series, notably the 4-chloro- and 4-fluorophenyl analogues, demonstrated pharmacological activity in the range of imipramine. Both compounds provided a marked potentiation of the 5-hydroxytryptophan-facilitated monosynaptic spike in the spinal cat preparation.

Animals↗

PubMed1983