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Biomedical subjects

E Rudzki

Publications and source records attributed to E Rudzki.

At least 55 records · Page 3Linked to original sources

Contact sensitivity to systemically administered drugs.

Allergic occupational dermatitis to drugs usually administered systemically is found most often in nurses. Affected less frequently are physicians, veterinarians, dentists, hospital cleaning people, and pharmaceutical manufacturing workers. The drug most often involved in the author's experience is penicillin.

Dermatitis, Contact↗

Patch tests with occupational contactants in nurses, doctors and dentists.

In this study, 333 nurses, 92 dentists and 167 doctors were investigated. Most positive patch tests obtained were unrelated to occupation. Nurses were most often sensitized to penicillins and, of the disinfectants, formaldehyde was the commonest cause of occupational dermatitis. Among dentists, the most common occupational allergens were eugenol and mercuric chloride. Among surgeons, as compared with physicians, there were frequent reactions to mercuric chloride and balsam of Peru, and a higher number of positive patch tests with other contactants. Among those sensitized to chromium, 4 doctors found that contact with chromic catgut was harmful. 6 other doctors were intolerant to surgical gloves. A number of nurses and doctors had an irritant contact dermatitis from chlorhexidine.

Dentists↗

Dermatitis from quinazoline oxide.

Dermatitis from 2-chloromethyl-4-phenyl-6-chloroquinazoline-3-oxide, an intermediate product in the preparation of chlorodiazepoxide, is described in 29 workers at a pharmaceutical plant. All were patch test positive to quinazoline oxide (1%) and six to 0.05%. In most patients, the face was earlier and more severely involved than the hands. Some were sensitized even if they did not have much contact with it, doing such work as washing the clothing of other workers, or working at a distance of 100 m from the production line building.

Dermatitis, Contact↗