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Biomedical subjects

E Rudzki

Publications and source records attributed to E Rudzki.

At least 19 recordsLinked to original sources

[Coexistence of asthma and certain symptoms of atopic dermatitis].

The frequency of basic and minor features of atopic dermatitis were compared between 86 patients with coexistent asthma, and 269 without asthma. The coexistence of asthma caused a statistically significantly more frequent presence of one of the basic features: personal or family history of atopy and five minor features. The latter included: early age of onset, recurrent conjunctivitis, tendency toward cutaneous infections, elevated serum IgE and keratosis pilaris.

Adolescent

Clinical features of atopic dermatitis and a family history of atopy.

In 365 children and 213 adults the characteristics of atopic dermatitis isolated by Hanifin and Rajka were analysed in relation to a family history of allergy. A positive history in both parents and/or their families was associated with higher IgE titres, earlier appearance of skin changes, more frequent occurrence of urticaria, allergic respiratory diseases, cheilitis, and, in women, nipple eczema. These changes were less frequent and the IgE titre was lower in patients with one atopic parent, and even less frequent (or lower IgE titre) in patients with no family history of atopic disease, although the latter difference was sometimes slight.

Adolescent

RAST and PRIST in children with atopic dermatitis.

The study was carried out in 535 children. The frequency of positive RAST for food allergens decreased with age, whereas the frequency of positive RAST for inhalant allergens increased with age. Coexistence of asthma and/or rhinitis was not related to the results of RAST with food allergens. Positive RAST and multiple sensitivity for inhalant allergens were significantly greater in children with coexistence atopic respiratory disease. Total IgE was significantly higher in children with coexistent atopic respiratory disease in all age groups. This study provides information for the critical analysis of a RAST in atopic dermatitis.

Adolescent

Contact sensitivity to systemically administered drugs.

Allergic occupational dermatitis to drugs usually administered systemically is found most often in nurses. Affected less frequently are physicians, veterinarians, dentists, hospital cleaning people, and pharmaceutical manufacturing workers. The drug most often involved in the author's experience is penicillin.

Dermatitis, Contact

Patch tests with occupational contactants in nurses, doctors and dentists.

In this study, 333 nurses, 92 dentists and 167 doctors were investigated. Most positive patch tests obtained were unrelated to occupation. Nurses were most often sensitized to penicillins and, of the disinfectants, formaldehyde was the commonest cause of occupational dermatitis. Among dentists, the most common occupational allergens were eugenol and mercuric chloride. Among surgeons, as compared with physicians, there were frequent reactions to mercuric chloride and balsam of Peru, and a higher number of positive patch tests with other contactants. Among those sensitized to chromium, 4 doctors found that contact with chromic catgut was harmful. 6 other doctors were intolerant to surgical gloves. A number of nurses and doctors had an irritant contact dermatitis from chlorhexidine.

Dentists

Contact sensitivity to phenylglycidyl ether.

From among 40 workers with dermatitis who did not have contact with phenylglycidyl ether but worked with epoxy resins, 5 were positive to Epidian 5 and phenylglycidyl ether. Cross reactions between these contactants were noted in 3 of the 17 guinea pigs with primary sensitization to epoxy resin or the tested diluent. For 58 persons coming into contact with phenylglycidyl ether the frequency of sensitization to the contactant was determined and the mean period between starting work and the occurrence of dermatitis was calculated.

Animals

Occupational dermatitis among health service workers.

Health service workers in the number of 152 suffering of dermatitis were examined. They included 43 physicians, 25 stomatologists, 59 nurses, 14 hospital-wards and 12 other persons working in hospitals, clinics and pharmacies. In physicians occupational contact dermatitis occured in ten patients, exclusively among those performing operations, most frequently surgeons and ginecologists. Rubber gloves (5 patients) disinfectants and chromic catgut were the sensitizing objects. Moreover, a woman gynecologist positive to nickel observed that also the use of a speculum exacerbated her lesions. A laryngologist with seborrhoic dermatitis, strongly positive to formaldehyde, had exacerbations when using--during surgery--a microscope disinfected with formalin solution. Allergic occupational contact dermatitis was diagnosed in 12 stomatologists; they were positive to eugenol, mercury, novocaine or formaldehyde. Among 24 nurses with allergic occupational contact dermatitis, those positive to antibiotics (specially to semisynthetic penicillins) or to disinfectants (most of them to formaldehyde) were most numerous. Some nurses were sensitive to such drugs as Propranolol, Aminophyllinum or chlorpromazine hydrochloride. To the latter drug also a ward attendant was positive.

Dermatitis, Contact