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Biomedical subjects

E Rubin

Publications and source records attributed to E Rubin.

At least 325 records · Page 18Linked to original sources
PubMed1968

Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol.

The feeding of ethanol increased significantly the activities of hepatic pentobarbital and benzpyrene hydroxylases in rats, and, in human volunteers, doubled pentobarbital hydroxylase activity. In vitro ethanol inhibited aniline, pentobarbital, and benzpyrene hydroxylases. These data may explain, at least in part, the increased tolerance of alcoholics to sedatives when sober, and the enhanced sensitivity to sedatives when inebriated.

Alcoholism↗
PubMed1968

Ethanol increases hepatic smooth endoplasmic reticulum and drug-metabolizing enzymes.

Rats were fed ethanol for 2 weeks along with diets either adequate or deficient in protein and choline, the latter intake being similar to that of many alcoholics. Hepatic lipids, smooth endoplasmic reticulum, and the activities of drug-metabolizing enzymes (aniline hydroxylase and nitroreductase) were increased with the adequate diet but more so with the deficient one. These results may explain the increased tolerance by alcoholics of drugs such as sedatives.

Alcoholism↗