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Biomedical subjects

E Ross

Publications and source records attributed to E Ross.

At least 127 records · Page 7Linked to original sources

Pertussis vaccine and whooping cough as risk factors in acute neurological illness and death in young children.

The National Childhood Encephalopathy Study received reports on 1182 cases of serious acute neurological illnesses in children admitted to hospital in Britain. The frequency of risk factors in cases was compared with matched controls. A personal or family history of convulsions was found significantly more often in cases than in controls, but no such excess was found for a history of allergy. Case children were significantly more likely to have received diphtheria, tetanus and pertussis (DTP) vaccine within seven days before onset and to have a history of whooping cough during the month of onset. The risk of serious acute brain conditions after the disease was more than six times that of three doses of DTP. In addition, there is evidence that deaths attributed to whooping cough may seriously underestimate the number associated with pertussis infection.

Brain Diseases↗

Brain stem vascular malformation simulating a hemorrhagic metastasis: report of a case with pathologic correlation.

A 65-year-old woman with known breast carcinoma developed headaches, followed shortly by disequilibrium, vertical diplopia and dysarthria. Cranial computerized tomography (CCT) demonstrated a dense, irregularly enhancing pontine lesion with associated mass effect. She received dexamethasone (Decadron) and radiotherapy and subsequently expired. Postmortem examination disclosed a ruptured brain stem arteriovenous malformation within a massive hemorrhage along with necrotic atypical cells suggestive of metastatic disease.

Aged↗

Sleep apnea with unusual EEG changes in Jakob-Creutzfeldt disease.

Disruption of the periodic pattern in the EEG was observed in a patient with Jakob-Creutzfeldt disease. Periods of apnea (during 'sleep') were associated with abrupt cessation of the periodic complexes and their replacement by 7-9 c/sec waves which persisted throughout the apneic episode. The periodic complexes reappeared on termination of the apnea. This close temporal association between disruption of the periodicity and apneic episodes suggests proximity of respiratory neurons and the deep subcortical pacemaker.

Brain↗

Evaporative cooling of laying hens in Hawaii.

A study was conducted to determine the effects of evaporative cooling on laying hens in a tropical environment of high relative humidity. Four strains of Single Comb White Leghorn pullets totaling 1,248 birds were housed in two identical enclosed houses except that in one the incoming air was passed through an air wash prior to entering the unit. The maximum temperature averaged 3.0 C lower and the relative humidity 15% higher in the unit cooled by evaporation. No significant differences were noted among any of the production parameters measured, although there was a numerical advantage for the evaporatively cooled unit in egg production, egg size, egg specific gravity, cracked eggs, and mortality. There were no consistent differences among the strains between the two units.

Air↗

The physiological effects of feeding warfarin poultry.

A 20 week study using layer and broiler strain chicks of both sexes was undertaken to determine whether poultry were susceptible to warfarin-induced granulomatous endocardial lesions. Birds were fed a corn-soybean meal basal diet with no added vitamin K, supplemented with either 0, 25, 50, or 100 ppm of warfarin or vitamin K at .6 mg/kg of diet. Broiler chicks showed a higher incidence of hemorrhages, more mortality, and longer prothrombin times than did the layer strain fed the same diets. Regardless of the breed, female chicks fed the highest warfarin level had significantly longer prothrombin times than the male chicks. However, there were no sex differences associated with mortality or incidence of hemorrhages among birds fed the experimental diets. Growth was most significantly reduced for chicks fed the highest warfarin level and to a lesser degree for birds fed 50 ppm of warfarin. In contrast to the first 10 weeks of the study, there was a sharp decline in mortality, incidence of hemorrhages, and prothrombin times during the last 10 weeks of the study. Layer and broiler strains of chickens fed warfarin for 20 weeks showed no evidence of granulomatous endocardial lesions as was reported for swine (Oshiro and Brooks, 1975).

Animals↗

The effect of water sodium on the chick requirement for dietary sodium.

Two strains of broiler chicks fed a basal wheat-soybean diet designed to be complete in all known nutrients failed to achieve optimal growth at 3 weeks of age. Increments of dietary sodium resulted in increased growth responses and improved feed efficiencies (P less than .05) which were not related to genotype. The sodium requirements for optimum weight gain was found to be greater than the NRC (1971) requirement when the water sodium level was 3 ppm. The addition of 50 ppm of sodium to the drinking water improved growth and feed efficiency (P less than .05) of birds fed the basal diet. When 100 ppm of sodium was added to the drinking water, a further increase in growth was obtained equivalent to that of birds receiving the basal diet to which increments of sodium were added up to .15%. Sodium in the drinking water was shown to be utilized more effectively than was sodium in the feed.

Animals↗

A comparison of treatment effectiveness of nonaddict and exaddict professionals in an adolescent treatment program.

This paper examines the relative effectiveness of the nonaddict professional and the exaddict professional in an adolescent drug abuse treatment program. Based upon statistical and clinical considerations, the authors' conclusion is that exaddict professionals untrained in psychology or a related health field should perhaps not work with adolescents who present with drug and mental health problems. Strengths and weaknesses of each group are discussed, as is clinical effectiveness with respect to client retention and discharge rates. Age, race and sex were explored relative to length of employment. It was found that exaddict professionals left work significantly more often than nonaddict professionals as a result of negative or unethical behavior.

Adolescent↗

Apparent inadequacy of sodium requirement in broiler chickens.

Wheat-soy and corn-soy basal diets designed to be complete in all known nutrients failed to support normal growth and feed efficiency of male broiler chicks to two weeks of age. Highly significant growth responses to these diets were obtained from the addition of faba meal (Vicia faba L.) or of 0.2% Na2SO4. Subsequent studies showed these diets to be deficient in sodium even though they contained, by analysis, 0.13 or 0.14% of sodium. A very low sodium content of the drinking water (3 p.p.m.) is believed to be contributory to this deficient state. A significant growth response was obtained from the addition of 0.2% sodium (0.33% total sodium) whether from NaCl or a combination of NaCl and Na2SO4. These data suggest that it may be important to consider the sodium content of the drinking water when determining the sodium requirement of the chick. A further response was obtained from 5.0 p.p.m. procaine penicillin G suggesting the presence of some toxic substance in the feed ingredients or that a subclinical infection may also have contributed to the poor growth supported by the basal diets.

Animal Feed↗

Cytochrome c1 of bakers' yeast. I. Isolation and properties.

Cytochrome c1 has been purified from mitochondria of the yeast Saccharomyces cerevisiae. The procedure involves solubilization withcholate, ammonium sulfate fractionation, disruption of the dytochrome b-c1 complex with mercaptoethanol and detergents, and chromatography on DEAE-cellulose. The final product is psectrally pure, contains up to 62 nmol of covalently bound heme per mg of protein and does not react with oxygen or carbon monoxide. Sodium dodecyl sulfate disaggregates the purified cytochrome into a single 31,000 dalton subunit carrying the covalently attached heme group. Many cytochrome c1 preparations contain in addition an 18,500 dalton polypeptide which is devoid of covalently bound heme. Since this polypeptide can be removed from the heme-carrying polypeptide by relatively mild procedures, it is probably not an essential subunit of cytochrome c1. Cytochrome c1 is extremely sensitive to proteolysis. If it si purified in the absence of protease inhibitors, a family of heme polypeptides with molecular weights of 29,000, 27,000, and 25,000 daltons is obtained. In the presence of the protease inhibitor phenylmethylsulfonylfluoride the purification yields predominantly a 31,000 dalton heme protein with only little contamination by a 29,000 dalton degradation product. In order to show that only the 31,000 dalton heme-polypeptide is the native species, yeast cells were labeled with the heme-precursor delta-amino[3H]levulinic acid, converted to protoplasts and directly lysed with dodecyl sulfate in the presence of protease inhibitors. Subsequent electrophoresis of the lysate in the presence of dodecyl sulfate reveals the covalently bound heme of cytochrome c1 as a single symmetrical peak at 31,000 daltons.

Amino Acids↗