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Biomedical subjects

E Romero

Publications and source records attributed to E Romero.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Effect on quality of life with a new insulin injection device in elderly patients with diabetes mellitus type 2.

OBJECTIVE: The aim was to investigate the efficacy, safety, and satisfaction of a new insulin injection device in elderly subjects with type 2 diabetes on suboptimal glycemic control with two doses of insulin NPH alone. RESEARCH DESIGN AND METHODS: This study was a prospective no-blind study performed. We selected 25 patients (13 men and 12 women) with type 2 diabetes, only treated with two doses of NPH insulin (injection pen device) for more than 6 months, who did not achieved optimal glycemic control. Additional inclusion criterion was age 55 to 75 years (mean 65.6+/-8.6). All subjects were required to be able to comply with the protocol and carry out home blood glucose monitoring. RESULTS: HbA1c decreased significantly from 7.8% to 7.6% (P<.05) (2.6% decreased from baseline), and breakfast and lunch preprandial glucose controls decreased significantly. Significant decrease was detected in breakfast and dinner postprandial glucose level. Taken the patients as a whole, insulin dose change significantly (29.8+/-10.9 to 28+/-10.8 Ul/day; P<.05). The number of hypoglycemic events during the 3-month treatment was similar than before treatment with Innolet (2.3+/-3.9 to 1.4+/-2.6 events; ns). The summary results indicated significantly improvement satisfaction questionnaire before 23.9+/-9 points and after 34.5+/-6.5 insulin injection device (P<.05). CONCLUSION: Innolet improved glycemic control and satisfaction in a group of elderly patients with diabetes mellitus type 2 previously treated with pen devices.

Aged↗
PubMedDate not supplied

Fungaemia in hospitalized patients.

At various clinics of IRCCS S. Matteo Hospital, Pavia, Italy, 269 blood cultures recovered from immunocompromised patients over 4 years have been examined mycologically. Of the 269 cultures, 101 were from HIV-infected patients and five were from cardiac transplant recipients. Of the total examined 96 blood cultures were positive (36%). The most frequent genus was Candida: C. albicans (48%), C. tropicalis and C. parapsilosis (8% each), C. glabrata and C. guillermondii (3% each). Cryptococcus neoformans was detected in 21 patients (22%).

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

[Changes in intake pattern in obese patients treated with paroxetine].

GOAL: Drugs used in cases of obesity can be classified in several groups: those which increase thermogenesis; those which reduce the absorption of fats; and those which reduce the appetite. It seems that the last named group affects the intake pattern. The goal of our study was to assess the change in eating habits and the adherence to the diet by obese patients treated with paroxetin. SCOPE: The population studied comprised 14 obese patients. All of them were prescribed a diet of 1,500 calories/day in two groups: Group I (n = 7; only diet) and Group II (n = 7; diet plus paroxetin). After three months, a 24-hour nutritional survey was carried out to compare habitual intake with recommended intake. RESULTS: The intake of Group I was significantly greater than in Group II in terms of total calories (2,094.2 +/- 415 calories/day) versus 1,403.4 +/- 368 cal/day; p < 0.05), grammes of protein (100.2 +/- 19.6 g/day versus 63.2 +/- 8.1 g/day; p < 0.05) and carbohydrates (218.8 +/- 60.8 g/day versus 164.3 +/- 64.1 g/day; p < 0.05), and there were no significant differences in the amount or type of fat eaten. There were differences in the consumption of iron (14.2 +/- 2.4 mg/day versus 8.7 +/- 1.7 mg/day; p < 0.05), phosphorus (1,623.5 +/- 301.9 mg/day versus 1,001.8 +/- 255.6 mg/day; p < 0.05) and potassium (3,820 +/- 1,629 mg/day versus 2,560 +/- 557 mg/day; p < 0.05), with the remainder of minerals and vitamins not presenting significant differences. In conclusion, paroxetin modifies the intake pattern by reducing the amounts of calorie, proteins and carbohydrates consumed.

Adult↗
PubMedDate not supplied

[Non-pigmented melanoma of the rectum].

A 49 year-old woman underwent a palliative abdominoperineal resection because rectal adenocarcinoma that produced pain, bleeding and transanal tumor protrussion. Histologic studies showed and amelanotic melanoma. She died 3 months later. Any pigmented lesion in the anorectum must be excised to rule out melanoma. In some cases abdominoperineal resection may be done but as the majority of patients have metastases at the time of diagnosis, paliative wide local excision is the preferred treatment of this highly letal neoplasm.

Female↗
PubMedDate not supplied

Connection between two peripherical markers in a group of asthmatic patients.

We have studied the goniometric value of the tda angle and the alpha 1 antitrypsin phenotypes in a group of thirty atopic patients with the following patterns: 1) they were affected with asthma, atopic dermatitis and rhinitis. 2) they presented positive prick skin tests for pneumo-allergens and had. 3) positive allergic antecedents. There exists a significant statistical value for the lower tda angle in the right hand, in the MZ phenotypes of alpha 1 antitrypsin bearers, with P less than 0.05 significance. In the left hand there are many individual values that are identical (62% of the total test effected) thus the statistical methods cannot be applied satisfactorily, bearing in mind the significant difference as the statistical group recognized. From this and other previous works, we can conclude that an individual whose right hand tda angle reaches values near 75%, and with a MZ phenotype of alpha 1 antitrypsin, has a greater possibility of pertaining to one of the groups of asthma, atopic dermatitis and rhinitis symptomatology.

Asthma↗