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Biomedical subjects

E Rolandi

Publications and source records attributed to E Rolandi.

At least 73 records · Page 4Linked to original sources
PubMed1983

Changes of pituitary secretion after long-term treatment with hydergine, in elderly patients.

The aim of this study was to evaluate the effects of long-term treatment with an ergot derivative, dihydroergotoxine mesylate (hydergine) 6 mg/day, on pituitary secretion on 10 elderly patients of both sexes. Samples were drawn at 120 min intervals during a 24 h period, before and after 1 month of therapy. Serum levels of Prl, GH, LH, FSH, TSH and cortisol were measured by RIAs. Hydergine induced a significant increase in the nocturnal serum GH peak. Conversely, no appreciable changes in the pattern of the other hormones studied were found. The observed endocrine effects could be due to the chronic dopaminergic stimulation induced by hydergine.

Age Factors↗
PubMed1983

Changes in pituitary secretion induced by an agonist-antagonist opioid drug, buprenorphine.

The im administration in 6 healthy subjects of buprenorphine, a derivative of the morphine alkaloid thebaine with agonist-antagonist properties, resulted in a significant rise of serum Prl within 45-240 min, a small and transient increase in serum GH and a significant fall in serum cortisol values. Conversely, no appreciable changes in the serum levels of the other hormones studied were found. The observed hormonal effects indicate that, in man, buprenorphine exerts an opiate agonist rather than an opiate antagonist effect.

Adult↗
PubMed1982

Influence of low doses of naloxone on pituitary secretion in man.

Naloxone 0.8 mg im administered to eight healthy subjects did not affect the serum levels of GH, LH, FSH, PRL, TSH and cortisol. Pretreatment with naloxone 0.8 mg increased TRH-induced TSH and PRL release in six healthy subjects. The same pretreatment caused an enhancement of haloperidol-induced PRL secretion in further other group of six subjects.

Adult↗
PubMed1982

Evaluation of Prl secretion in elderly subjects.

Prl secretion was evaluated in 76 elderly patients (71-86z years) without endocrine disorders (38 men and 38 women) in basal conditions, after TRH, sulpiride and levodopa administration and during a 24 h period. An impaired Prl response to the administered drugs was found in the elderly women but not in the men. On the contrary, normal sleep-related serum Prl changes were found in the majority of the subjects studied. These results suggest that the pituitary gland can maintain a good Prl secretory pattern in the elderly.

Age Factors↗
PubMed1981

Hormonal changes induced by a partial opiate antagonist, nalorphine. Evaluation of PRL, GH, TSH, LH, FSH and cortisol secretion.

The effects of nalorphine 5 mg i. m., a partial opiate antagonist, on circulating levels of PRL, GH, TSH, LH, FSH and cortisol were studied in six healthy men. Nalorphine produced a produced a prompt and sharp increase in serum PRL and a small, delayed rise in serum GH. Serum LH and cortisol decreased after drug administration and no change in serum FSH and TSH was observed. These findings are discussed and a possible site of action of nalorphine is suggested.

Adult↗
PubMed1981

Effect of a psychoactive drug, trazodone, on prolactin secretion in man.

Administration of 50 mg trazodone, an antidepressant drug, in a single oral dose to 10 normal subjects of both sexes, aged 24--41, resulted in a significant (p less than 0.01) decrease of serum prolactin (PRL) values. The mean serum PRL levels were 8.9 +/- 2.2 ng/ml in basal conditions and 4.5 +/- 1.7 ng/ml 180 min after trazodone. Pretreatment with trazodone does not modify TRH-induced PRL release.

Adult↗
PubMed1981

Dopamine receptor blockade induced by metoclopramide and thyroid-stimulating hormone secretion in man.

20 mg metoclopramide, intramuscularly administered to 10 healthy males and 10 healthy females, induced a significant increase in serum thyroid-stimulating hormone values in female subjects only. This finding suggests that dopamine does not play a major role in the regulation of thyroid-stimulating hormone secretion and that estrogens can act in the modulation of dopamine effects at the hypothalamic and/or pituitary level.

Adult↗
PubMed1981

Prolactin secretion in benign prostatic hypertrophy.

Prolactin secretion was evaluated in 22 patients with benign prostatic hypertrophy, before and after thyrotropin-releasing hormone stimulation. Increased prolactin reserve was found. In 11 patients, in whom the test was performed twice, the prolactin response after surgery was higher than in the pre-surgical test. The possible role of prolactin in the genesis of benign prostatic hypertrophy is discussed.

Aged↗
PubMed1981

Comparison of mezlocillin and carbenicillin as therapy for various infectious diseases.

The efficacy and safety of mezlocillin, a new broad-spectrum semisynthetic penicillin, were compared with those of carbenicillin in a nonblind, controlled clinical study in 89 adult patients. The infections treated were primarily those of the urinary tract, skin, and gastrointestinal or hepatobiliary tract. Escherichia coli, Proteus mirabilis, Proteus morganii, and Pseudomonas aeruginosa were the causative organisms isolated most frequently. A complete resolution of signs and symptoms was achieved in 78% of the mezlocillin patients and in 71% of the carbenicillin patients. In the mezlocillin group, causative organisms were eliminated in 80% of the courses, and in the carbenicillin group the elimination rate was 86%. Two adverse reactions, rash and diarrhea, were reported in mezlocillin-treated patients; none were reported for the carbenicillin group.

Adult↗
PubMed1980

Evaluation of twenty-four-hour secretory patterns of growth hormone and insulin in patients with myotonic dystrophy.

Twenty-four-hour secretory patterns of GH and insulin were evaluated in seven patients with myotonic dystrophy. We found an impairment of sleep-related GH secretion and an increase of nocturnal serum insulin levels. There was no correlation between hormonal behavior and severity of disease. It is possible that the observed hormonal dysfunction is related to a multisystem disorder in myotonic dystrophy.

Adult↗
PubMed1980

Evaluation of anterior pituitary function in patients with posttraumatic diabetes insipidus.

Serum LH, FSH, TSH, PRL, GH, and cortisol were measured in 10 patients with posttraumatic diabetes insipidus both basally and after a combined insulin-induced hypoglycemia, LRH and TRH test. Two patients did not show hormonal abnormalities, while 8 patients had deficiencies of 1 or more hormones. The most frequent abnormality was GH deficiency (50%), followed by TSH (40%), ACTH (30%), FSH (30%0, and LH (20%). These results indicate that anterior pituitary dysfunction frequently accompanies posttraumatic diabetes insipidus.

Adolescent↗
PubMed1980

Evaluation of LH, FSH, TSH, Prl, and GH secretion in patients suffering from prostatic neoplasms.

The concentration of luteinizing hormone (LH), of follicle stimulating hormone (FSH), of thyroid stimulating hormone (TSH), of prolactin (Prl) and of growth hormone (GH) was evaluated, in basal conditions and during stimulation tests, in serum of 32 patients with benign prostatic hypertrophy (BPH), of 29 patients suffering from prostatic carcinoma and of a control group of similar age. Significant difference in pituitary Prl secretion was found between the prostatic patients and the control group.

Aged↗
PubMed1979

[Effects of somatostatin upon prolactin secretion both in normal subjects and in patients presenting pituitary adenoma (author's transl)].

In normal subjects somatostatin cannot modify the plasma levels of prolactin when they are in a normal range or when they are pharmacologically increased. In the case of pituitary adenoma (prolactinic or eosinophilic), the response of prolactin to somatostatin varies widely. In some patients there is a marked decrease of the prolactin levels while in others no modification is observed.

Acromegaly↗