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Biomedical subjects

E Roegel

Publications and source records attributed to E Roegel.

At least 37 records · Page 2Linked to original sources

[Diffuse interstitial pneumopathy related to tungsten carbide, confirmed by bronchoalveolar lavage, and responding to corticotherapy].

The authors report a case of severe diffuse interstitial hard metal lung disease responding to corticosteroid therapy. They point out that the course of this disease may be regressive and emphasise that analysis of broncho-alveolar washings showed no abnormality in the differential cell count. Mineralogical study of the same material confirmed exposure.

Adrenal Cortex Hormones↗

[Recurrent sarcoidosis in skin scars disclosing repeated thoracic sarcoidosis].

Recurrence of thoracic sarcoidosis after spontaneous regression is extremely rare. Its existence is proven by two new cases associating sarcoidosis with L ofgren 's syndrome and sarcoid in skin scars, the latter facilitating the recognition of the presence of thoracic disease. Surveillance of the behaviour of scars forms part of routine examinations in the sarcoid patient. Even when there has been total spontaneous regression, subsequent clinical and radiological follow-up every two years must be continued.

Adult↗

[Home oxygen therapy of chronic bronchitis patients. Clinical, functional and pulmonary hemodynamic results. Apropos of 17 cases].

UNLABELLED: Seventeen subjects (16 male, 1 female) with a mean age of 60 +/- 7 years were studied. INCLUSION CRITERIA: severe chronic bronchitis (mean FEV1 = 960 ml with frank hypoxaemia (PaO2 less than 60 mmHg); past history of right heart failure or electrical signs of right ventricular hypertrophy or pulmonary hypertension (PAP greater than 20 mmHg); oxygen therapy at home for greater than 10/24 hours (most often greater than or equal to 12 hours) for more than a year; interval of more than 6 months between the first haemodynamic investigation (before the start of O2) and the last, this period being on average 23.9 +/- 18.6 months. From a clinical standpoint, there were 5 deaths occurring 11 to 30 months after the start of O2. Effort dyspnoea was stable or worsened but hospitalisations for cardiorespiratory decompensation were less frequent than before the start of O2. There were no significant changes in arterial blood gases: PaO2 rose from 51.9 +/- 8.1 to 52.5 +/- 7.0 mmHg. PAP improved in 12 cases out of 17, and for the group as a whole the difference was not statistically significant. However in the sub-group where the daily duration of administration was greater than 12/24 hours (n = 7), PAP improved in all the individual cases and fell on average from 26.4 +/- 6.8 to 19.9 +/- 3.4 mmHg (p less than 0.02) whilst in the 10-12 hours sub-group there was no mean change in PAP.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

[5-year survival of resected bronchial cancer. Multifactorial analysis of its prognosis].

Prognosis in patients having undergone surgery for a bronchial carcinoma (oat cell. carcinoma excluded) was studied by comparing, with two statistical methods, a group of 178 patients surviving five years and more (group I) and a group of 178 patients who died within five years (group II). The two groups had undergone treatment during the same period. Comparison of the two groups suggested that the following factors were indicators of a good prognosis: ratio weight-height within normal limits without recent weight loss, fortuitous detection of the carcinoma; normal aspect on bronchoscopy; T1 N0 type without vascular extension, limited exeresis. Recurrences of the carcinoma were generally observed in group II but could be present in group I. The differential prognosis between pulmonary metastases and a "new" bronchial carcinoma was difficult. Survival was finally determined by the frequency of recurrences and metastases. By a correspondences factorial analysis it was possible to separate and to define the main characteristics of the patients with a good prognosis and a long survival and of those with a poor prognosis and a short survival. However this proved to be exact in only 30% of the individual cases because occurrence of metastases was generally unforeseable. From these data it appears that surgery alone is indicated in only one kind of tumours; T1 N0 carcinomas detected by routine examinations.

Aged↗

[Pleural effusion as the presenting feature of rheumatoid disease. The value of the level of complement in the pleural fluid. A propos of 2 cases].

The authors report two cases of rheumatoid pleural effusion where the pleural syndrome preceded the joint manifestations. From a clinical standpoint, there was an effusion of moderate volume, pseudo-purulent in one case and straw coloured in the other. Signs of rheumatoid arthritis developed after a period of seven weeks in the first case and after a few days only in the second. Amongst the various characteristics of the pleural fluid which were analysed, the authors noted the value of a fall in glucose level, the lack of specificity of anti-gamma globulin factors, and the diagnostic value of the fall in pleural complement and its fractions. In view of the difficulty in obtaining specific histological proof by pleural biopsy, the reduced complement level is of valuable assistance in the aetiological diagnosis of rheumatoid pleural effusion, exceptional as a presenting feature.

Aged↗

[Three new cases of pulmonary fibrosis in finishers of tools reinforced with tungsten carbide (author's transl)].

On the basis of three new cases of pulmonary fibrosis due to heavy metals, the authors review the various clinical, radiological and respiratory function test criteria which lead to the diagnosis of this type of occupational fibrosis. This is an uncommon disease (21 cases published up to the present in France), insufficiently known, but with significant and sometimes severe risks. On July 19th 1980, the disease was added to the list of occupational diseases with No 70.

Adult↗

[Silicosis with a rapid and pseudo-tumoral course occurring in a case of pre-existant progressive and treated pulmonary sarcoidosis in a miner little exposed to silicosis risk : sarcoido-silicosis (author's transl)].

The authors report the case of a miner suffering from pulmonary and nodal sarcoidosis treated with corticosteroids where during a multivisceral exacerbation with iritis and erythema nodosum there developed rapidly progressive pseudo-tumoral silicosis. Pulmonary and nodal biopsies by thoracotomy revealed silicotic masses in the upper lobe, penetrated and bordered by sarcoid granulomas. In the middle lobe and hilar nodes, only sarcoid process was present. This new entity, sarcoido-silicosis, follows its own course, insensitive to corticosteroids. By virtue of its immune status, sarcoidosis favourised the rapid development of silicosis, the latter being unexpected since exposure had been moderate. Deficiency in the elimination of silica particles from the lungs is discussed. A trial of treatment using aluminium hydroxy-allantoinate did not lead to any conclusion.

Adrenal Cortex Hormones↗

[Transbronchial lymph node biopsy in the diagnosis of sarcoidosis (author's transl)].

Two hundred and fifty eight transbronchial lymph node biopsies using a Menghini type needle 1.5 mm in diameter were performed in 193 patients with a radiological and clinical picture suggestive of sarcoidosis. In 73 cases, the histological argument for the diagnosis was provided solely by this technique. The combination of two methods of obtaining material (multiple biopsies and transbronchial puncture) during rigid bronchoscopy led to a histological diagnosis in 77.7% of patients. The authors emphasize the relative safety of the method, as well as its value when material obtained by fibroscopy has proven to be unsatisfactory.

Biopsy↗

[Indication or surgical abstention in the treatment of emphysematous bullae (author's transl)].

During a 9-year period from 1968 to 1977, in the case of bullae measuring at least 10 cm diameter, 21 surgical interventions and 31 conservative treatments were performed. The indications were either peremptory (irreductible pneumothorax, acute extension of the bullae) or spontaneously determined using a series of detailed criteria. The frequency of bronchial cancer occurring in the emphysematous bullae is noteworthy (8 cases out of 55 observations).

Bronchial Neoplasms↗

[Pulmonary aspergillosis. Apropos of 5 anatomo-clinical cases].

The authors report five cases of invading and diffuse pulmonary aspergillosis. Clinically they are characterized by a development in a still clear pulmonary field in patients with a lessened organic resistance and under corticosteroid treatment. Necrotic phenomenons occurred very quickly and prognosis was poor. Anatomically, foci were spreading, rapidly necrosing and contained Aspergillus. Diagnosis was based, besides etiological circumstances, on the presence of Aspergillus in sputum and of anti-aspergillus precipitins in serum.

Adrenal Cortex Hormones↗