Search PubMed⌕ Search

Biomedical subjects

E Rodin

Publications and source records attributed to E Rodin.

At least 37 records · Page 2Linked to original sources
PubMed1982

Brainstem auditory evoked potential recording in patients with epilepsy.

The brain stem auditory evoked potential (BSAEP) was recorded in 32 normal control subjects and 81 epileptic patients. Statistically significant differences in regard to sex and laterality of ear stimulated were found to exist in both groups. The epileptic patients also had significantly longer latencies for all wave components and interwaves I-III as well as I-IV than the normal controls. There were no differences in regard to interwave latency III-V. Clinically significant latency prolongations (more than three standard deviations from the norm) were encountered especially in regard to waves I and III. Correlations of wave and interwave latencies with a large variety of clinical variables showed that statistically significant relationships existed mainly in regard to presence or absence of brain damage and the severity of the seizure disorder, as expressed by the number of different seizure types to which a given patient was subject. Waves II and III showed the most consistent latency prolongations for these variables. Anticonvulsant medication levels did affect wave latencies, but apart from Primidone, it involved waves IV through VII rather than II and III. Carbamazepine levels were related to prolongation of I-III interwave latency. It is concluded that severely brain-damaged epileptic patients have demonstrable brain stem dysfunction affecting mainly the medullo-pontine rather than midbrain or thalamic structures.

Adult↗
PubMed1982

Epileptic patients who are refractory to anticonvulsant medications.

To evaluate criteria that predict success or failure of currently available anticonvulsant medications, we studied 194 epileptic patients who were admitted to an intensive treatment unit. Seizures were present in the hospital in 78.3% and could not be controlled in 33.7%. Combinations of at least two of the following criteria were associated with limited treatment responses: multiple handicap (intellectual limitations or abnormal neurologic signs), different seizure types, cluster seizures, slowing of EEG background rhythms, and seizures discharges in the EEG despite adequate anticonvulsant blood levels. Presumed etiology was not associated with predictive ability. Patients who were neurologically and intellectually intact and had frequent clinical attacks, normal EEG background rhythms, and no seizure discharges usually had pseudoseizures.

Adult↗
PubMed1977

The results of penicillin G Administration of chronic unrestrained cats: electrographic and behavioral observations.

Intramuscular administration of penicillin G was carried out in a series of 27 chronic cat preparations. In addition to the EEG, the high frequency components of cerebral electrical activity were also recorded from cortical and deep structures. Videotape recordings using split-screen technique allowed correlations of the animal's clinical state with the EEG. The results showed that 'spike-wave' type activity occurred earliest in the cortex. The discharges were also best formed in cortical and thalamic structures. The other deep structures showed characteristic bursting, but not of the 'spikewave' type variety. The cerebellum showed also early participation. Clinical expressivity of the bursts depended upon the state of alertness of the animal, the height of the spike components and the extent of depth participation. The high frequency recordings revealed characteristic alternation of decrease and increase in activity mostly in cortical structures and to a lesser extent in thalamus. Pontine and medullary reticular formation areas showed usually no changes in the high frequency records during the bursts. When major seizures were induced, they were always of focal onset rather than of the primary generalized type as one sees with pentylenetetrazol. Different cortical or deep structures served as the initiating site in different animals. It was concluded that systemic penicillin adminstration does not lead to a truly primary generalized form of epilepsy, but produces its effects by multifocal activation of various cerebral structures, with cortex and cerebullum usually showing earliest involvement.

Animals↗
PubMed1976

The grand mal pattern of Gibbs, Gibbs and Lennox.

The "grand mal" pattern of Gibbs, Gibbs and Lennox was observed in records of 14 patients during the past 3 years. It occurs most commonly in those epileptic patients who suffer from primary generalized seizures of more than one seizure type and in whom akinetic attacks are the main clinical problem. In addition, there is usually some degree of intellectual limitations. The EEG features and clinical accompaniments of the discharge were described and since the term "grand mal" discharge is not appropriate, it is suggested that it be replaced by either "generalized repetitive fast discharge", as had been suggested in the European literature, or "beta band seizure pattern".

Adolescent↗