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Biomedical subjects

E Ritz

Publications and source records attributed to E Ritz.

At least 1,099 records · Page 61Linked to original sources
PubMedDate not supplied

Atherogenesis in experimental uremia.

The development of experimental atherosclerosis was studied in subtotally nephrectomized rats which were subjected to preimmunization with horseradish peroxidase and subsequent feeding with atherogenic diet. Both in sham-operated pair-fed control animals and in uremic animals, the atherogenic diet caused hyperlipemia which was more pronounced in uremic than in control animals (control animals: triglycerides 1.11 +/- 0.04 mmol/l; cholesterol 5.82 +/- 0.21 mmol/l; uremia: triglycerides 1.33 +/- 0.06; cholesterol 10.9 +/- 0.31). An increase of cholesterol was seen both in the VLDL and in the LDL fractions. Despite more pronounced hyperlipemia, lipid concentration in the aortic wall was not increased nor were more marked histological abnormalities encountered in the aorta of uremic animals (cholesterol-fed control: cholesterol 95.4 +/- 4.4 micrograms/mg protein; phospholipids 2.42 +/- 0.9 micrograms/ml protein; cholesterol-fed uremia: cholesterol 96.8 +/- 4.9; phospholipids 2.52 +/- 0.8). The results suggest that despite hyperlipemia short-term experimental renal insufficiency does not promote atherogenesis.

Animals↗
PubMedDate not supplied

Anaphylactoid reactions in dialysis patients: role of ethylene-oxide.

To determine whether anaphylactoid reactions during dialysis are the result of allergy to ethylene oxide (EtO) used for sterilisation of dialysis equipment, EtO-specific cytophilic antibodies on basophils were detected by means of a sensitive protease-release assay. Antibodies were found in 2 of 44 healthy controls, 2 of 16 staff members, 4 of 17 patients with preterminal uraemia, and 35 of 83 dialysis patients. 22 of the dialysis patients with antibodies, but only 9 of those without had anaphylactoid reactions during dialysis. Symptoms were more common in patients with antibodies. Symptoms and antibodies were less in a unit where dialysers were rinsed more thoroughly, and were increased in patients with a history of atopy. EtO antibodies decreased or became undetectable in patients who were dialysed with non-EtO-sterilised equipment for eight weeks, and symptoms improved strikingly. On re-exposure to EtO-sterilised material, symptoms returned and EtO-induced protease release increased. EtO sterilisation of dialysis equipment should be discontinued.

Adult↗