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Biomedical subjects

E Richter

Publications and source records attributed to E Richter.

At least 361 records · Page 20Linked to original sources
PubMed1975

Heteroagglutinins and spontaneous rosette-forming cells in obese strain (OS) chickens.

Sera of OS chickens with spontaneous autoimmune thyroiditis (SAT) and of normal white Leghorn (NWL) controls, aged 4-20 weeks, were studied for the presence of heteroagglutinins to sheep (SRBC) and rabbit red blood cells (RRBC). Significantly higher frequency and titers of SRBC- and RRBC-agglutinins were found in OS as compared to NWL birds, the difference being more accentuated with RRBC. The number of spontaneously rosette-forming peripheral blood lymphocytes (RFC) with SRBC and RRBC was determined in 20-week-old OS and NWL chickens. The number of RRBC-RFC was found to be significantly elevated in the OS. The value of RFC did not correlate with the individual heteroagglutinin titers. RFC and heteroagglutinin secreting cells are considered to be nonidentical. These results are discussed in the light of the previously established hyperreactivity of the B-dependent portion of the immune system in OS chickens.

Animals↗
PubMed1975

Thyroglobulin-binding lymphoid cells in obese strain (OS) chickens.

The binding of chicken thyroglobulin-coated chicken red blood cells by splenic, thymic, and bursal lymphoid cells was analysed in Obese strain (OS) chickens with spontaneous autoimmune thyroiditis and normal white Leghorn controls aged 1 week to 2.5 yr. Chicken erythrocytes coated with pneumococcal polysaccharide SIIII served as controls. The specificity of thyroglobulin-rosette-forming cells was verified by inhibition experiments. OS chickens showed significantly higher counts of thyroglobulin-rosette-forming cells in the spleen and thymus as compared to normal controls while no such difference was found for SII-rosette-forming cells. The values obtained with bursal lymphoid cells were in the same range in both OS and normal white Leghorn birds. The appearance of thyroglobulin-rosette-forming cells and their peak values clearly preceded the maximum frequency and severity of thyroiditis and the peak of the thyroglobulin antibody curve. It is concluded that the presence of thyroglobulin rosette-forming cells is a prerequisite for the future development of spontaneous autoimmune thyroiditis in the OS. Inhibition studies with specific turkey anti-chicken bursa and thymus cell sera revealed the B cell nature of active thyroglobulin-rosette-forming cells and suggested that passive rosette-forming cells were of T cell origin.

Animals↗