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Biomedical subjects

E Rebentisch

Publications and source records attributed to E Rebentisch.

At least 19 recordsLinked to original sources

[Hearing loss caused by leisure noise].

Although noise in general can induce hearing loss, environmental noise represents an important risk for children, teenagers and young adults. Epidemiological investigations now support the occurrence of an increasing number of irreversible hearing losses in these groups. Major causes of hearing loss are toys (guns), explosives and electroacoustically amplified music delivered by head sets or heard in discotheques and open air concerts. Clinical indications are discussed.

Adolescent↗

Improvement in inner ear blood flow by nitric oxide following experimentally induced cochlear thrombosis in anesthetized guinea pigs.

The nitric oxide (NO) donor sodium nitropruside (SNP) applied to the round window membrane has recently been found to increase cochlear blood flow (CoBF) in normal guinea pigs and in normal and presbyacusic mice. This study examined the effect of topical applications of SNP on experimentally impaired CoBF in anesthetized guinea pigs. Small (3 microliters) portions of 3% SNP were applied to the round window niche of both normal and thrombosed cochleas. Local vascular impairment was produced by ferromagnetic thrombosis of cochlear blood vessels and the microcirculation measured using laser Doppler flowmetry. Ferromagnetic thrombosis resulted in a mean decrease of CoBF to 52% of baseline. There was a clear improvement in mean CoBF to 84% of baseline by the topical application of SNP that depended on the degree of ischemic damage produced. Under neuroleptanalgesia and ketamine-xylazine anesthesia, significant increases in CoBF were measured in normal ears as well as in the thrombosed ones. However, several SNP applications were needed to improve the impaired CoBF, while a single portion was sufficient in the normal cochlea to cause a drastic increase in mean CoBF to 234% of baseline. In urethane-anesthetized animals, no flow increase was found despite repeated drug administration. Careful evaluation of the laser Doppler signals was necessary to accurately determine the concentrations of the moving blood cells and their mean velocities.

Administration, Topical↗

Oral magnesium supplementation as prophylaxis for noise-induced hearing loss: results of a double blind field study.

The effect of oral Mg-supplementation as prophylaxis against noise-induced hearing loss was tested in a placebo-controlled double blind study involving 320 voluntary subjects during a 2-month period of military training. The hearing thresholds of all subjects were checked and only persons with normal hearing were accepted. Before and after the 2-month training, blood samples were collected and Mg was analysed in serum, erythrocytes and lymphocytes. Seven days after the last exposure to firearm noise, the audiograms of all test subjects were checked and permanent threshold shifts (PTS) were determined. The total group received a drink containing either 4g Mg granulate verum (6.7 mmol Mg aspartate) or placebo every working day during the 2-month training period. The primary source of noise exposure were firearms: 420 shots per person, mean peak level 164 dB(A). The recruits used ear plugs with a mean insertion loss of 25 dB. In both groups Mg-concentration in serum and in erythrocytes increased with time. Lymphocyte Mg increased in the Mg group only. In the placebo group the percentages of ears with PTS > 25 dB at 4 kHz/6 kHz and/or 8 kHz after exposure to firearm noise were twice as high as in the Mg group.

Administration, Oral↗

Annoyance and health risk caused by military low-altitude flight noise.

Effects of noise of low-flying military jet aircraft were investigated from demoscopic and epidemiological points of view. Areas with different low-altitude flight noise exposure were compared with one another as to subjective annoyance, casual blood pressure and ear symptoms. With the same energy equivalent sound pressure level (Leq), the subjective disturbance caused by military low-altitude flight noise was essentially greater than that due to ordinary flight noise (in the neighbourhood of civil airports). A comparison of several areas revealed that frequencies of ear symptoms (tinnitus lasting more than one hour and permanent hearing threshold shifts of greater than 30 dB) were higher only in areas where maximal flight noise levels considerably exceeded 115 dB (A) accompanied by rapid noise level increases. Blood pressure measurements yielded significantly higher values (group difference 9 mm Hg systolic) in girls living in these highly exposed areas. Acoustic limits are proposed with respect to public health.

Adolescent↗

Acute circulatory effects of military low-altitude flight noise.

Volunteers aged 70 to 89 years living in a senior citizen's home in Haifa were exposed to flight noise via earphones while watching video films. Their blood pressure and heart rates were measured simultaneously. A high-quality recording and reproduction technique was employed. They were exposed to the noise of two to three overflights with Lmax = 99-114 dB(A) and slow sound pressure level increase (aircraft take off) or with Lmax = 95-112 dB(A) and a fast sound pressure level increase (low-altitude flight at high subsonic speed) at intervals of 10 to 15 min. The systolic and diastolic blood pressure was raised at Lmax = 112 dB(A) and high speed level increase at the average of 23 and 13 mmHg, respectively with individual maximal values of about 40 mm Hg (systolic). In order to prevent risks to the subjects' health, the noise exposure was not raised to levels above 112 dB(A) and fast level increase, although Lmax = 125 dB(A) has been measured in 75 m-low-altitude flight areas. The blood pressure response to a repeated single exposure increased in proportion to the preceding noise exposure. At high intensities and fast level increase an up to fourfold reaction intensification was detected in the majority of subjects. This change in reactivity is regarded as the result of sensitization toward the special type of noise and the implications of these observations for the long-term effects of chronic exposure to low-altitude flight noise are considered. On the basis of these results, proposals are made for limiting values for Lmax and for the speed of sound pressure level increase, the implementation of which would lead to a marked reduction in health risks from low-altitude flight noise.

Aged↗

Correlations between ventricular arrhythmias and electrolyte disturbances after acute myocardial infarction.

Seven 24-hour ECG recordings and blood samples were taken within 3 weeks in 42 patients who had suffered an acute myocardial infarction (AMI). Ca, K and Mg concentrations in serum, and K and Mg in the erythrocytes, were determined by atomic absorption spectroscopy. One half of the patients were infused with 81 mval/day MgSO4 for 3 days. In patients who exhibited intense electrolyte alterations 10-20 days after AMI, there was a significantly higher rate in the frequency of couplets and/or tachycardia in the 2- to 20-day period after AMI. In patients infused with MgSO4, the fluctuation in serum electrolytes and the rate of arrhythmias were significantly reduced.

Aged↗

Protection against salicylate ototoxicity by zinc.

One day after oral application of 700 mg (5.5 mmol)/kg salicylic acid given as Na salicylate, hearing thresholds in rats, measured by acoustically evoked responses at 10 and 20 kHz, were increased. Salicylate-induced hearing loss was completely prevented by simultaneous s.c. injection of 6 mg (92 mumol)/kg Zn, whereas simultaneous s.c. injection of 1.5 mmol/kg MgCl2 had no effect. Simultaneous s.c. injection of 100 mg (152 mumol)/kg desferrioxamine had only a minor beneficial effect indicating that salicylate-induced Fe accumulation plays no significant role in salicylate ototoxicity.

Animals↗

Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency.

In rats, Mg deficiency caused a moderate hearing loss, measured by means of evoked potentials at 10 and 20 kHz, which was repaired after refeeding a normal diet. Application of 700 mg/kg salicylic acid or injection of 5 x 100 mg/kg gentamicin also caused a reversible hearing loss in normally fed rats. Treatment of Zn-deficient rats with salicylic acid produced a stronger although reversible hearing loss than in normally fed salicylate-treated rats. Treatment of Mg-deficient rats with gentamicin induced a strong hearing loss that was nearly complete and irreversible in 9 of 25 rats.

Animals↗

[State dependent modification of auditory brain stem potentials].

It is well known, amplitudes and latencies of auditory brain stem potentials are almost independent of viligance state. Contrary to that, simple cognitive requirements effect amplitude changes (enhancement of variance, amplitude reduction) in a part 2/3) of the subjects.

Adolescent↗