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Biomedical subjects

E Röder

Publications and source records attributed to E Röder.

At least 19 recordsLinked to original sources
PubMed2003

Bronchodilating effects of cumulative doses of formoterol from a novel multi-dose inhaler (Airmax).

The bronchodilating properties of formoterol from a novel multi-dose inhaler, Airmax 6 microg and from a single-dose dry powder inhaler Foradil Aeroliser 12 microg were investigated in 31 adult asthmatics with FEV1 > or = 60% predicted and a reversibility > or = 12%. Patients received on a single day four doses of formoterol: cumulative dose 6, 12, 24 and 48 microg from Airmax, or 12, 24, 48 and 96 microg from Aeroliser. The mean FEV1 (SD) from baseline to 1 h after the final cumulative dose increased by 0.81 l from 2.62 (0.58) to 3.43 l (0.70) with Airmax and by 0.85 l from 2.65 (0.60) to 3.5 l (0.68) with Aeroliser. All 90% CIs for all four dose comparisons were within the equivalence range +/- 0.11. There was a higher incidence of hypokalaemia and hyperglycaemia at highest doses during treatment with the Aeroliser than with Airmax. In conclusion, formoterol delivered from Airmax provides a dose-dependent bronchodilating effect which is similar to that obtained by Aeroliser, at double the dose.

Administration, Inhalation↗
PubMed1998

Generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine.

Monoclonal antibodies against retrorsine were established using a retrorsine-hemisuccinate::bovine-thyroglobuline conjugate as antigen for immunization. In competitive enzyme-linked immunoassays the specificity of the obtained antibodies was tested with 20 different pyrrolizidine alkaloids. Among these the alkaloids acetylgynuramine, gynuramine, integerrimine, neoplatyphylline, platyphylline, rosmarinine, senecionine, and seneciphylline were able to bind the antibody. There was no cross-reactivity with the alkaloids senkirkine, angeloyl-heliotridine, heliotridine, axillarine, anacrotine, monocrotaline, madurensine, otosenine, retronecine, tussilagine, triangularine, and jacoline as well as with seneciphylline N-oxide. From this antigen spectrum it can be concluded that besides the necic structure itself the dominant and discriminative epitope consists of the exocyclic ethylidene group of the various diesters.

Animals↗
PubMed1989

[Studies on the effect of an alkaloid extract of Symphytum officinale on human lymphocyte cultures].

An alkaloid extract of Symphytum officinale was investigated for its chromosome-damaging effect in human lymphocytes in vitro. In concentrations of 1.4 micrograms/ml and 14 micrograms/ml the alkaloids had no effect, in concentrations of 140 micrograms/ml and 1400 micrograms/ml the alkaloids induced sister chromatid exchanges (SCE) as well as chromosome aberrations. Additionally, the influence of rat liver enzymes (S9) was tested. The SCE-inducing capacity and the clastogenic effect of Symphytum alkaloids was increased by simultaneous application of S9-Mix.

Alkaloids↗
PubMed1982

Carcinogenic and mutagenic activity of an alkaloidal extract of Senecio nemorensis ssp. fuchsii.

The alkaloidal residue obtained after extraction of dried and pulverized Senecio nemorensis ssp. fuchsii contains two pyrrolizidine alkaloids, i.e. fuchsisenecionine and senecionine. In a chronic experiment doses of 8 mg/kg and 40 mg/kg b.w. of the alkaloidal extract were given five times a week by gavage to male and female Sprague-Dawley rats. The study was terminated after 114 weeks. Repeated serum analysis demonstrated a dose-related elevation of serum glutamic oxalacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and alkaline phosphatase (AP). Beside its hepatotoxic effect, the treatment proved to be hepatocarcinogenic, showing female rats to be more sensitive than males. Tumors diagnosed were of hepatocellular and angiogenic origin. In age-adjusted analysis the occurrence of these neoplasms revealed a clear dose-related trend (p less than 0.00005). In the in-vitro mutagenicity test system with V 79 Chinese hamster cells, the alkaloidal extract exerted a weak but dose-related mutagenic activity. Under the conditions used the alkaloidal extract of Senecio nemorensis ssp. fuchsii is a genotoxic carcinogen.

Alkaline Phosphatase↗
PubMed1981

[On the stability of homoeopathic dilutions in glass and plastic containers (author's transl)].

Adsorption of traces of gold, iron, zinc and mercury, labelled with 195Au, 59Fe, 65ZN, 203Hg, was studied in dependence on time as well as on the container-material and composition of the solution. With exception of the zinc-solutions in all other solutions a considerable decrease was ascertained. Acid- or silicone-treatment of the surfaces shortly cause altered adsorption properties, but cannot prevent a sorption. From the different adsorption behaviour of the investigated elements one can conclude that the different affinity and adhesive power of the ions must be referred to their different chemical and physical properties.

Adsorption↗