Sixty-nine patients with multiple sclerosis from 12 to 53 years of age were examined. The titre of measles antibody in the blood serum (geometric mean) was 9.0 log2 in the patients and 5.1 log2 in normal subjects of the control group. The antibody titre was found to depend upon the stage of the disease: the sera collected in the period of remission had a titre of 7.3 log2, and those collected in the exacerbation stage 10.7 log2. Nineteen patients were examined both during remission and at the time of exacerbation: their antibody titres were 6.8 and 10.7 log2, respectively. The antibody titre did not depend upon duration of the disease, sex or age of the patients. Antibody in the cerebrospinal fluid was detected in 3 out of 8 patients in the stage of remission and in 6 out of 9 patients in the stage of exacerbation. In 4 out of 11 patients, measles immunoglobulins of the M class were found by means of serum fractionation in sucrose density gradient.

Adolescent↗

PubMedDate not supplied

[The incidence of epidemic mumps and the rate of antibody detection in different age groups of Moscow population].

Sera from Moscow residents of different ages were studied by the HI test for antibody to mumps virus. In newborn babies antibody was found in 94%. The number of subject possessing antibody decreased with age and was minimal among children of 3-4 years (40%) but then increased and reached 94% among adults (20 years or more).

Adolescent↗

PubMedDate not supplied

[Bovine viruses and methods for their detection].

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Adenoviridae↗

PubMedDate not supplied

[Characteristics of Namalwa cells--a substrate for production of human interferon].

The properties of lymphoid Namalwa cell line propagated at the USSR Academy of Medical Sciences Research Institute of Viral Preparations for interferon production are described. The scanning and transmissive electron microscopy studies of the cells showed their morphological stability and the absence of microbial contamination. The 46-48-chromosome cells comprised 85% of the population, hypodiploid cells (44-45 chromosomes), 9%, tetraploid and hypertetraploid cells, 3%. Spontaneous aberrations were detected in 3% of the chromosome. Inoculation of the cells into unsuppressed laboratory animals (rabbits, guinea pigs, adult or suckling mice) or chick embryos did not cause the development of any pathological process. Namalwa cells were shown to produce interferon after multiple (up to 4 times) induction with Newcastle disease virus.

Burkitt Lymphoma↗

PubMedDate not supplied

[Interferon and therapy of oncological diseases].

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Humans↗

PubMedDate not supplied

[Isolation of purified and concentrated human interferon from Namalwa cells].

The interferon produced in the cultured Namalwa cells was purified and concentrated according to the method of K. Cantell and S. Hirvonen developed for purification of leukocyte interferon. A preparation concentrated 500-fold had the antiviral activity of 10(6) IU/ml at a specific activity of 1-3 X 10(6) per 1 mg of protein. The amount of protein in the preparation was approximately 0.6 mg/ml, that of cell DNA less than 100 ng/ml. The experiments demonstrated that the virus inducer of interferon and possible contaminant viruses were removed on purification. The preparation had no oncogenic potency on inoculation of newborn Syrian hamsters, was harmless by intraperitoneal inoculation of mice and on multiple inoculations on rabbit eye cornea, was not toxic in cell cultures.

Animals↗

PubMedDate not supplied