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Biomedical subjects

E R Morgan

Publications and source records attributed to E R Morgan.

35 records · Page 2Linked to original sources
PubMed1988

Single copies of the N-myc oncogene in neuroblastomas from children presenting with the syndrome of opsoclonus-myoclonus.

Patients with neuroblastoma who present with the syndrome of opsoclonus and myoclonus enjoy a remarkably good prognosis independent of their stage of disease or their age at diagnosis. The presence of N-myc amplification also has been found to be an independent prognostic factor in neuroblastoma. Patients with multicopy N-myc tumors have rapid tumor progression whereas those with single-copy tumors have a significantly better progression-free survival. The authors examined four primary, untreated neuroblastomas for the N-myc copy number from patients who presented with opsoclonus and myoclonus. All four tumors had single copies of N-myc, and all four patients are alive with no evidence of recurrent disease with 6+ to 54+ months' follow-up. This appears to be the only report of N-myc analysis in this group of children. It would be interesting to analyze more neuroblastomas from patients who present with opsoclonus and myoclonus to determine how many of these patients have single N-myc copy tumors.

Child, Preschool↗
PubMed1987

The spectrum of metabolic bone disease in lymphoblastic leukemia.

Eight patients with childhood acute lymphoblastic leukemia (ALL) and hypercalcemia, osteopenia, or vertebral compression fractures seen at our institution during the last 12 years were evaluated for biochemical evidence of bone disease. Five patients were hypercalcemic, three had abnormal phosphorous levels, and four had elevated alkaline phosphatase values. Parathyroid hormone (PTH) was measured by a polyvalent radioimmunoassay in five patients and these levels were abnormally high in three patients. Four of these five patients also had PTH measured by a midregion-specific radioimmunoassay. One patient had a high PTH value. Two patients had low levels and one patient had a normal PTH level. Although these studies suggest diverse biochemical mechanisms may be contributing to the bone changes and hypercalcemia seen in childhood ALL, ectopic PTH production as well as ectopically produced fragments of PTH may have a role in mediating bone resorption and hypercalcemia.

Adolescent↗
PubMed1985

Enhancement of antigen expression on acute lymphoblastic leukemia (ALL) cells by cell incubation.

Leukemic cells from blood and/or marrow specimens of 64 acute lymphoblastic leukemia (ALL) patients were examined for the expression of the Ia-like antigen (Ia) or ALL cell-associated antigen (ALLA) employing indirect immunofluorescent techniques before and after overnight incubation (18 hours) at room temperature in Roswell Park Memorial Institute medium 1640. In 20 cases, the post-incubation cells showed an augmented intensity of the fluorescent stain and an increased (greater than 15%) percentage of the ALLA and/or Ia-bearing cells. Evaluation of cell viability after incubation and of non-specific staining in control preparations using normal rabbit serum in lieu of specific rabbit antiserum to ALLA or Ia excluded selective cell death and increased non-specific stain as causes of the observed increase in fluorescent cell staining. The enhanced antigen expression was observed in those samples in which antigens were detectable on only a small fraction of the leukemic cells. The results demonstrate the necessity of re-examination of leukemic cells for the presence of ALLA and Ia following overnight incubation especially in antigen negative cases.

Antigens, Neoplasm↗
PubMed1983

Varicella in immunocompromised children. Incidence of abdominal pain and organ involvement.

The medical records of 31 immunocompromised patients who experienced varicella infections from 1975 to 1982 were reviewed. Fifteen of these patients had visceral involvement. In these 15 patients, two clinical patterns of progression were noted: (1) Eleven patients with life-threatening involvement experienced hepatitis (n = 11), pneumonitis (n = 11), abdominal pain (n = 11), encephalopathy (n = 10), coagulopathy (n = 10), inappropriate antidiuretic hormone (ADH) syndrome (n = 10), back pain or myalgia (n = 5), and myocarditis (n = 1). Seven of these patients survived, all without sequelae. (2) Four patients with a milder course experienced subclinical hepatitis (n = 4), mild pneumonitis (n = 4), postinfectious encephalitis (n = 1), and septic arthritis associated with disseminated intravascular coagulopathy (n = 1). All four of these patients recovered completely. In patients with severe involvement, intense abdominal pain was frequently the first sign of dissemination. Abdominal pain and inappropriate ADH syndrome were unexplained and have not been previously described in progressive varicella. A predictable pattern of organ involvement enabled starting therapy early and resulted in the survival of 11 of 15 patients.

Abdomen↗
PubMed1983

Wilms' tumor.

Explore the source record for details and available documents.

Child↗
PubMed1982

Myelofibrosis in neuroblastoma.

Myelofibrosis, a rare childhood disorder, has been reported as an associated complication of certain hematologic malignancies or as an isolated idiopathic process. In this report, we describe a patient with metastatic neuroblastoma whose initial presentation included the findings of myelofibrosis and leukoerythroblastosis. The myelofibrosis regressed with chemotherapy and did not recur when the patient's tumor reappeared.

Abdominal Neoplasms↗
PubMed1982

Endodermal sinus tumor: a clinical and pathological correlation.

Endodermal sinus tumors occur in the gonads and in a variety of extragonadal locations, particularly as the malignant component of sacral teratomas. Light and electron microscopic studies as well as the presence of alpha fetoprotein support the concept that these lesions arise from germ cells that migrate from the extraembryonic yolk sac. These tumors in all locations are highly malignant and metastasize to lymph nodes, lung, liver and bone. Peritoneal implants are seen from tumors in the ovary, testis, and following ventriculoperitoneal shunts for yolk sac tumors of the pineal gland. There is no satisfactory therapy for the endodermal sinus tumor, regardless of location, when there are distant metastases at the time of diagnosis; however, we have documented complete regression of metastases in one child following therapy with vinblastine, bleomycin, and cis-platinum. Nine of 13 boys with endodermal sinus tumors of the testis survived in this series of patients. All survivors were treated with orchiectomy and lymph node excision. Surgical excision combined with chemotherapy and radiation led to survivors in children with large extragonadal pelvic and retroperitoneal tumors. We recommend vigorous multimodal therapy with surgery and chemotherapy. Radiation is given to the primary lesion when it is too extensive for initial resection or to eradicate residual disease following chemotherapy. Alpha fetoprotein is a valuable tumor marker.

Adolescent↗
PubMed1981

Ovarian granulocytic sarcoma as the primary manifestation of acute infantile myelomonocytic leukemia.

The first known instance of granulocytic sarcoma of the ovary as the presenting manifestation of acute nonlymphocytic leukemia in infancy is reported. The clinical and laboratory findings for a 3-month-old infant who had anemia and a lower abdominal mass subsequently found to represent bilateral ovarian granulocytic sarcomas are discussed. Results of light and electron microscopic examination of bone marrow biopsy specimen were consistent with a diagnosis of acute myelomonocytic leukemia. Hematopoietic (and lymphoproliferative) disorders must be included in the differential diagnosis of ovarian masses in children.

Bone Marrow↗
PubMed1981

Nail hyperpigmentation secondary to therapy with doxorubicin.

Hyperpigmentation of the fingernails can occur during therapy with doxorubicin (Adriamycin). Two patterns are common: diffuse, and transversely banded. The pigment is believed to be melanin, and both patterns disappeared with discontinuation of therapy and subsequent nail growth.

Adolescent↗
PubMed1978

Detection of B-lymphocyte (B-cell)-associated antigens on human leukemic lymphocytes. Masking of membrane antigens.

An indirect immunofluorescent technic has been used for rabbit antisera (anti-EP) that demonstrated complement-dependent cytotoxicity against human leukemic lymphocytes but not against normal blood lymphocytes. With the immunofluorescent technic, the antisera were found to react with 2--23% of normal blood lymphocytes. Simultaneous staining of normal cells with anti-EP and for surface immunoglobulins (SIg) on bone-marrow-derived B-cells showed that the proportions of stained cells were similar to percentages of cells stained by anti-EP alone or for SIg alone. The percentage of anti-EP reactive cells also approximated the percentages of cells reactive to a known antiserum to human B-cell associated, or Ia-like, antigens. The anti-EP reacted with lymphoblastoid cells from two B-cell lines lacking the Epstein-Barr viral genome. The antigens detected by anti-EP probably are B-cell-associated. The anti-EP intensely stained neoplastic cells of acute or chronic lymphocytic leukemia and lymphosarcoma-cell leukemia. Cells from two patients with chronic lymphocytic leukemia and from two patients with acute lymphocytic leukemia showed increased intensity of anti-EP staining and/or increased proportions of stained cells following overnight incubation in culture medium, compared with the preincubation samples. This observation suggests the presence of a "blocking component(s)" on cell surfaces, which interfered with anti-EP reactivity. After overnight incubation, the component might have been removed from the antigenic sites on cell surfaces. Further studies of leukemia lymphocytes using anti-EP for the cell-bound "blocking component" may reveal important pathogenetic mechanisms.

Antigens, Surface↗