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Biomedical subjects

E R Jacobson

Publications and source records attributed to E R Jacobson.

At least 109 records · Page 6Linked to original sources
PubMed1985

Serum concentrations of gentamicin in cats.

Twenty-one adult cats, allotted into 2 groups, were given gentamicin sulfate at dosages of either 5.0 mg/kg of body weight or 2.5 mg/kg as a single IM injection. During a 24-hour period, serum concentrations of gentamicin were measured serially, using a fluorescence immunoassay. The mean peak serum concentration of gentamicin in cats given 5.0 mg/kg was 23.1 micrograms/ml at postinjection hour (PIH) 0.5; thereafter, the mean serum concentration steadily decreased to 2.0 micrograms/ml at PIH 24. The mean peak serum concentration for cats administered 2.5 mg/kg was 9.1 micrograms/ml at PIH 0.5; thereafter, the mean serum concentration steadily decreased to 1.3 micrograms/ml at PIH 12. Serum therapeutic concentrations, without exceeding toxic concentrations, were attained at the 2.5 mg/kg dosage.

Animals↗
PubMed1984

Epornitic of papova-like virus-associated disease in a psittacine nursery.

Of 45 fledgling psittacine birds being raised in an avian nursery, 14 died over a 6-week period. At necropsy, several birds were found to have a moderate amount of subcutaneous hemorrhage over the crop and across the dorsum. Histologically, all birds had hepatic necrosis. Large pale to lightly basophilic intranuclear inclusions were seen in the spleen of 6 birds and in the liver of 5 birds examined. Ultrastructural evaluation demonstrated intranuclear virus particles resembling the papovavirus incriminated as the agent responsible for budgerigar fledgling disease.

Animals↗
PubMed1984

Sarcocystis encephalitis in a cockatiel.

A sporozoan organism was considered to be the causative agent of central nervous system disease in a cockatiel. The ultrastructural characteristics were typical of the coccidian group Apicomplexa, and the fact that organisms were free within the cytoplasm of infected cells and not within a vacuole, indicated they were Sarcocystis. Light and electron microscopic evaluation of brain tissue demonstrated protozoal organisms associated with areas of necrosis. Differential diagnosis of central nervous system disease in pet birds should include protozoal encephalitis.

Animals↗
PubMed1983

Panophthalmitis and otitis interna in fire-bellied toads.

Microbiologic and histologic studies were made of fire-bellied toads with signs of ocular and central nervous system disease. Providencia alcalifaciens, Citrobacter freundii, Aeromonas hydrophila, and other gram-negative bacilli were isolated from the eyes and multiple tissues of ill toads. The histologic evaluations revealed severe panophthalmitis and otitis interna.

Animals↗
PubMed1983

Steatitis and fat necrosis in captive alligators.

Steatitis and fat necrosis were identified in a group of 123 American alligators (Alligator mississippiensis) kept in an enclosed pond and fed a diet of only fish for more than 10 years. All affected animals were outwardly healthy and had had no signs of disease in the period immediately before slaughter. The diagnosis was made at the time of commercial slaughter for harvest of meat and hides. Lesions consisted of firm yellow-brown masses distributed in fat tissue throughout the body. The histopathologic diagnosis was granulomatous steatitis, with fat necrosis, based on the finding of multinucleated giant cells, ceroid, and multiple foci of inflammatory cells.

Acute Disease↗
PubMed1983

Hematologic and serum chemical effects of a ketamine/xylazine combination when used for immobilizing springbok.

A ketamine hydrochloride/xylazine combination was found effective for immobilizing springbok. Following intramuscular injection by hand, the onset of immobilization ranged from 3 to 10 minutes and duration of immobilization ranged from 1 hour to 2 hours 20 minutes. Hematologic and serum chemical values before and after immobilization were compared. Serum alanine transaminase and serum glucose values were significantly higher after immobilization, whereas serum potassium was significantly lower.

Animals↗
PubMed1982

Herpesvirus-like infection in map turtles.

Two map turtles housed in an aquarium with a group of other map turtles became lethargic and anorectic, and subcutaneous edema developed prior to their deaths. Gross postmortem findings included subcutaneous edema and swollen, diffusely pale livers. Histologic examination of the livers revealed multifocal to diffuse areas of necrosis, with intranuclear eosinophilic inclusions in hepatocytes. Intranuclear and intracytoplasmic aggregates of particles morphologically resembling herpesvirus were identified in degenerating hepatocytes by electron microscopy.

Animals↗
PubMed1982

Papilloma-like virus infection in Bolivian side-neck turtles.

Five Bolivian side-neck turtles had multifocal small, round to confluent, white skin lesions distributed over the head. Several gram-negative microorganisms were isolated from the lesions. Light microscopy revealed hyperkeratosis and hyperplasia of the epidermis. Ultrastructural evaluation demonstrated crystalline aggregates of virus particles within nuclei of cells in the stratum granulosum and free within the stratum corneum. On the basis of size, location, arrangement, and tissue affected, the particles resembled papillomaviruses.

Animals↗
PubMed1982

Polycystic kidney and liver disease in Springbok: I. Morphology of the lesions.

Spontaneous polycystic kidney and liver disease in an inbred herd of Springbok (Antidorcas marsupialis) was studied by light microscopy, transmission electron microscopy, and microdissection. Springbok are a small species of gazelle of the family Bovidae native to South Africa. Since 1976, 18% of all live calves born have had nephromegaly and died within 2 weeks of birth. Examination of kidney and liver from ten calves which had died or were sacrifices since 1978 revealed bilateral, symmetrical nephromegaly due to moderate to marked focal dilatation of tubules predominately in the outer zone of the medulla. Microdissection of renal tissue from three affected calves indicated polycystic kidneys had cysts in all of the bends of Henle's loops, over half of the ascending limbs, and about one fourth of the collecting ducts. All of these calves had proliferation and cystic dilatation of bile ducts in most hepatic portal areas. The bile ducts were irregularly dilated and confluent with only a slight increase in periductular connective tissue. Ultrastructural studies revealed no consistent changes in the basement membranes of either the renal or hepatic cysts. This disease has several features similar to the autosomal recessive form of polycystic kidney disease in man and may prove a useful animal model.

Animals↗