Biomedical subjects
Publications and source records attributed to E R Carlson.
Myospherulosis is a complication of wound healing which results from an action between lipids and extravasated erythrocytes. A case of myospherulosis of the mandible is reviewed with its history, histopathology and occurrence.
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Polycythemia vera is a stem cell disorder that results in an increase in the production of red blood cells. Although numerous mechanisms have been suggested, the cause of the disease is unknown. Diagnosis is based on clinical and laboratory presentation. This article reviews the history of polycythemia vera and illustrates a representative case report of the disease process. Postoperative morbidity in the surgical patient is discussed with respect to preoperative therapeutic control. Recommendations are made for preoperative therapy in patients undergoing oral and maxillofacial surgery.
The lupus anticoagulant is a unique inhibitor of hemostasis. Its occurrence in patients with systemic lupus erythematosus reportedly varies from 5% to 50%. The inhibitor is endogenously produced and occurs in a diverse number of clinical states. The present case report reviews an inadvertent discovery of circulating lupus anticoagulant in a patient scheduled for surgery of the temporomandibular joint.
A retrospective study of 27 cases of untreated orbital blow-out fractures is presented. These patients were managed non-surgically because they presented with minimal ophthalmologic symptoms, or they sustained other injuries that prevented early repair. Twelve patients returned for follow-up examination and eight were contacted by telephone. In evaluating patients for diplopia, enophthalmos, hypesthesia, and restricted ocular movement, 85% showed complete resolution of symptoms. Based on these findings, surgical intervention is recommended only in those patients who demonstrate residual diplopia in primary gaze and restricted ocular motility that persist after 10 to 14 days, the presence of enophthalmos greater than 2 mm, and gross disruption of the orbital floor as confirmed by CT or tomography.
Absence of precipitation of calcium phosphate salts onto tooth surfaces from human saliva, which is supersaturated with respect to calcium phosphate salts, has been attributed in part to the presence in the salivary secretions of a group of acidic proline-rich phosphoproteins (PRP). These macromolecules are considered to act by adsorbing onto dental enamel where they inhibit surface-induced precipitation of calcium phosphate salts. The inhibitory activity is known to be associated primarily with the amino-terminal region of the PRP. The aim of this study was to determine the features of the primary structure of this molecular segment responsible for inhibitory activity. The 30-residue, amino-terminal segment of PRP-3, which contains the two phosphoserines and 11 of the 13 carboxyl groups present in PRP-3, was obtained by tryptic digestion. This peptide, designated PRP-3(TI), was treated with thermolysin to give the monophosphopeptides, Val-PSer-Gln-Glu-Asp-Val-Pro and Leu-Val-Ile-Ser-Asp-Gly-Gly-Asp-PSer-Glu-Gln, and with alkaline phosphatase to give the dephosphorylated analog, PRP-3(TI)DP. The inhibitory activities of PRP-3(TI) and the derived peptides, a synthetic peptide, phosphoseryl-phosphoserine (PSer-PSer), and O-phosphoserine (PSer), were determined using an assay based on inhibition of seeded precipitation of calcium phosphate. Inhibitory activities, expressed as concentrations of inhibitors required to give standard inhibitory activities, were PRP-3(TI), 0.59 microM; PSer-PSer, 3.5 microM; the two monophosphopeptides, 29 and 32.5 microM; PRP-3(TI)DP, 56 microM; PSer, 329 microM.(ABSTRACT TRUNCATED AT 250 WORDS)
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The use of PRP and rhBMP-2 in facial skeletal reconstruction is supported by theoretical and practical human and animal data that represent exciting prospects for the 21st century. Although the use of PRP in conjunction with autogenous grafting of the maxillofacial complex increases the already impressive predictability of this technique, it is possible that improvement of the clinical use of rhBMP-2 may one day obviate the need for a donor site harvest of bone.