[Pancreatic and bronchial anaplastic cancer].
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Bronchial Neoplasms↗
Biomedical subjects
E Quoix
Publications and source records attributed to E Quoix.
[Preliminary results concerning the value of chemotherapy in the treatment of inoperable bronchial carcinoma (excluding small-cell anaplastic carcinoma)].
Inoperable non- microcellular primary bronchial carcinomas have been reputed up to now to be chemo-resistant. The introduction of Cis-platinum into a polychemotherapy protocol leads to revision of this concept. The authors report the preliminary results of a polychemotherapy protocol (including Cis-platinum, Vindesine, CCNU, Cyclophosphamide) associated, in cases of non- metastasized carcinomas, with radiotherapy to the tumour itself, the mediastinum and the supraclavicular fossae. These results confirmed the value of such chemotherapy in forms with metastases. In localised inoperable forms, conclusions could be reached only on the basis of a randomised comparative trial of chemotherapy + radiotherapy versus radiotherapy alone.
Adult↗
[Bronchial asthma associated with anguilluliasis].
The authors present a case of a 46 year old man without any past history of allergy, who presented with severe asthma of recent onset associated with moderate eosinophilia, a raised total IgE level and a Larva currens type of dermatitis. Serology and stool culture revealed anguillulosis. The negative DLAC and the fact that the asthma disappeared after treatment of the parasitic infestation suggest that it was related to the anguillulosis.
Asthma↗
[Current review apropos of a case of unilateral agenesis of the pulmonary artery].
The authors review this rare malformation - unilateral agenesis of the pulmonary artery - on the basis of a recent case seen in the department. They point out the absence of any effect upon bronchial development of such an abnormality which may be explained by embryology and Reid's laws.
Adult↗
[Mac Leod syndrome].
The Mac Leod syndrome is a unilateral pulmonary hypoplasia with emphysema. Onset usually occurs in childhood. The authors delineate this well-defined nosologic entity which is one of the many etiologies of the unilateral hyperlucent lung.
Angiography↗
[Hereditary antithrombin III deficiency causing recurrent thrombo-embolic problems (author's transl)].
A marked deficiency in antithrombin III (AT III) was demonstrated in a 39-year-old man suffering from recurrent thrombo-embolic problems. The patient's father had died following a thrombo-embolic disorder. A certain number of members of the family also showed evidence of a marked decrease in AT III levels. Although it was not possible to study the patient's parents, it would seem reasonable to conclude that the diagnosis was one of hereditary deficiency in AT III. The various aspects of this disorder discovered by Egeberg are reviewed: early onset, in several members of the same family, or recurrent thrombo-embolic problems, accompanied by a decrease in functional activity of one of the principal inhibitors of thrombin (AT III), with autosomal dominant transmission and treatment based upon anti-vitamin K agents.
Adult↗
[Radiochemotherapy and radiosensitization for locally advanced non-small-cell bronchial cancer].
Combined chemotherapy and radiotherapy can improve the survival of patients with locally advanced non-small cell lung cancer, when compared to irradiation alone. This survival benefit is essentially due to an increased control of distant micrometastases, whereas local control remains poor. In order to improve local control, new radiotherapy modalities such as 3D conformal treatment, hyperfractionation or accelerated hyperfractionation, are under development. Cytotoxic drugs given at low doses concomitantly to radiotherapy may act as radiosensitizers on the primary tumor. Concomitant chemotherapy at cytotoxic doses and radiotherapy would also allow better control on micrometastases and better local control due to radiosensitization by chemotherapy. However, the concomitant use of chemotherapy and radiotherapy is limited by increased toxicity on normal tissues, more particularly on the esophagus. Randomized comparisons of these modalities versus induction chemotherapy followed by radiotherapy are needed to determine the optimal treatment sequence.
Antineoplastic Combined Chemotherapy Protocols↗
[IFCT --French Intergroup of Thoracic Cancerology: presentation, protocols].
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Bronchial Neoplasms↗
Small cell lung cancer: patients surviving longer than thirty months. Groupe d'oncologie de langue française.
The long-term survivors of SCLC are described in 3 different types of study: analysis of prognostic factors of phase II and III chemotherapy trials (3,4,5,6,7,17,18), epidemiological studies (8) and medical registries of LTS (9,10). A small number of patients with small cell lung cancer achieve long-term survival. Most of these patients have a disease limited to the chest at the time of diagnosis. The major concerns of these LTSs are: the relapse of the SCLC, the occurrence of a second primary tumour and the occurrence of a disease related to tobacco consumption. About 20% of the LTSs die of non-cancer related causes and this exceeds the age adjusted mortality. There is a high risk of relapse in the first 4 years after the diagnosis; this risk decreases later, but relapses may be seen until 7 years. Nearly 8% of LTSs developed a SPTs are alive at 8 years; this indicates that cure is possible in SCLC, however, these patients account for less than 3% of the overall population.
Aged↗