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Biomedical subjects

E Pretolani

Publications and source records attributed to E Pretolani.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Changes in blood filterability induced by risk factors for cardiovascular disease].

Our research was aimed at testing the role of the main cardiovascular risk factors in modifying the blood flow in microcirculation and in particular red cell deformability. To this end we determined by the method proposed by Reid and Dormandy (J. Clin. Pharmacol. 1976, 29, 855) whole-blood filterability in 15 smokers, 18 diabetics, 14 hypertensives, 16 dislipidemics, without clinical evidence of ischemic pathology and with negative vascular pathology anamnesis. In diabetics, hypertensives and dislipidemics blood filterability turned out to be significantly lower (p less than 0,001) that in 15 controls. In smokers it was also lower, although in a less significant way.

Blood↗
PubMed1983

[Hyperlipemia and erythrocyte filterability].

The erythrocyte filterability was examined in 30 patients presenting identical values of fibrinogen and polymorphonuclear leucocytes (10 patients had normal values of lipemia, cholesterol and triglycerides and in the other 20 patients one or more of these parameters were altered). In the first group filterability values were homogeneous, while in the second group they were higher and widely dispersed. A close proportionality between the reduced filterability rate and cholesterolemic values was also found.

Cholesterol↗
PubMed1980

[Preliminary clinical and experimental data on a new anti-arrhythmic drug: lorcainide].

A first series of personal results in the treatment of arrhythmia with lorcainide is presented. Findings were obtained by recording for 24 hr with Holter and compared with those observed in patients treated with quinidine. An ECG study was also made of the atrial and nodal refractory periods. The conclusion is drawn that lorcainaide possesses an undoubted and protracted anti-arrhythmic effect, and does not exert a significant influence on refractory period values.

Adult↗
PubMed1975

[Importance of digitalemia for a correct therapeutic attitude using cardioactive glycosides].

Recent advances in the quantitation of plasma or serum levels of cardiac glycosides promise to add a new dimension to pharmacologic studies and to the evaluation of clinical problems involving these drugs. A rapid radioimmunoassay technique has been described for the determination of serum digoxin and beta-metyldigoxin concentration in the range encountered clinically. Patients judged clinically to show digitals toxicity in general had higher levels. A relable estimate of serum digoxin and beta-metyldigoxin concentration, considered in the clinical context, has been found to be useful in arriving at acute management decisions.

Administration, Oral↗