Pituitary response to repeated injections of different doses of LH-RH in patients affected by hypogonadotropic hypogonadism.
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Follicle Stimulating Hormone↗
Biomedical subjects
E Porcu
Publications and source records attributed to E Porcu.
Induction of ovulation in polycystic ovary: human menopausal gonadotropin or human urinary follicle stimulating hormone?
One group of 21 and one group of 22 anovulatory women with polycystic ovaries (PCO) underwent induction of ovulation with human urinary follicle stimulating hormone (HU-FSH)/human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG)/HCG, respectively. No statistically significant differences in ovulation rate were found between patients treated with HU-FSH (95.2%) and those treated with HMG (100%). Eight (38.1%) and 11 (50.0%) patients conceived, six (28.5%) and eight (36.3%) delivered, and two (9.5%) and three (13.6%) aborted with HU-FSH and HMG, respectively. No multiple pregnancies occurred. Serum 17 beta-estradiol (E2) levels and the number of maturing follicles prior to HCG injection were significantly higher with HU-FSH than HMG, while there were no differences in the diameter of the dominant follicle before HCG. Ovarian hyperstimulations were discovered more frequently after HU-FSH/HCG (40%) than HMG/HCG treatments (22.2%). These data do not confirm an effective advantage in the use of HU-FSH in ovulation induction in cases of PCO.
Anovulation↗
The effects of desogestrel and ethinylestradiol combination in normal and hyperandrogenic young girls: speculations on contraception in adolescence.
Hormone profile and ovarian morphology were studied in two groups of adolescents (group 1:19 girls with slight signs of hyperandrogenism; group 2: 14 normal adolescents) in basal conditions and during a contraceptive combination of 30 micrograms ethinyl estradiol (EE) and 150 micrograms desogestrel (D). Treatment was associated with a low incidence of side effects in both groups. In group 1, acne generally improved within 12 months while hirsutism was only reduced in some subjects (58%) after 12 months of therapy (basal hair score 8.50 +/- 1.60 vs 5.81 +/- 1.53 p less than 0.001). Significant falls in plasma levels of LH, total and free testosterone and an increase in sex-hormone-binding globulin levels were observed during treatment especially in group 1. High percentage of multifollicular ovaries (75%) characterized hyperandrogenic subjects. Ovarian volume and number of follicles, higher in group 1 than 2 in basal conditions, showed a significant reduction in both groups and normal ovarian morphology was restored in hyperandrogenic subjects. Considering the high incidence of hyperandrogenemia in adolescence and its implications, our data suggest that the EE.D combination suits adolescent biological condition and is one of the suitable contraceptive methods in adolescents which also has therapeutic effects.
Acne Vulgaris↗
Induction of ovulation and pregnancy with HU-FSH (Metrodin) in women with polycystic ovarian disease: summary of clinical experience.
Ten infertile patients with polycystic ovaries, who failed to conceive with clomiphene citrate, were treated with human urinary follicle stimulating hormone. In the same group of subjects, three cycles of treatment were performed to induce ovulation and pregnancy. Ovulation occurred in sixteen cycles out of eighteen. Eight pregnancies were obtained; three ended in abortions, one was an extra-uterine pregnancy and four resulted in normal deliveries. No cases of real hyperstimulation were observed.
Adult↗
[The ovary at puberty].
Our investigation includes two groups of subjects in which the relationships between ovarian growth, steroidogenesis and gonadotropin secretion were studied. The first group consists of premenarchal girls studied in a cross-sectional program; the second group includes girls after menarche with irregular cycles who were investigated with a long term follow up. In the first group an increase in ovarian volume and in the number of developing follicles were seen with increasing chronological age and pubertal stages. With advancing pubertal development, a progressive increase of LH pulse frequency and amplitude can be observed. These variables appear strongly linked to the ovarian morphological and functional development as the significant correlation between LH mean levels and pulsatile characteristics on the one hand, and ovarian volume and steroid production on the other hand demonstrate. In the maturational stage just before menarche, the ovaries may show increased volume and a very dishomogeneous structure; ovarian steroidogenesis may be often mainly directed towards the androgen synthesis. After menarche ovarian volume and structure continue to change and normal or enlarged ovaries, with homogeneous, multifollicular or polycystic structure can be frequently observed. However normal and homogeneous ovaries prevail in adolescents with regular and ovulatory cycles, while enlarged and dishomogeneous ovaries prevail in irregular anovulatory cycles. A trend towards normal adult ovarian morphology and structure is present in ovulatory subjects with normal gonadotropin pulsatile release and steroid synthesis. On the other hand, deranged gonadotropin profiles imply irregular cycles anovolation, hyperandrogenemia and enlarged polycystic ovaries during adolescence.(ABSTRACT TRUNCATED AT 250 WORDS)
Adolescent↗