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Biomedical subjects

E Popescu

Publications and source records attributed to E Popescu.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Morphogenesis and pathogenesis of chronic lung diseases. XX. Effects of repeated hypersensitivity reactions upon experimental immuno-granulomas of the lung.

In order to analyse the effects of repeated hypersensitivity reactions upon chronic lung lesions, lung granulomas were experimentally induced in rabbits by an intravenous injection of 1 ml of the complete Freund's adjuvant added with 10 per cent human gammaglobulin. Groups of rabbits with 14- and 21-day-granulomas were intratracheally challenged with 1.000 I.U. human gammaglobulin injected two or three times at 7-9 days interval. The responses of the lung tissue were of the Arthus type with neutrophil granulocytic accumulations and proteasic action; the intensity of cell accumulations was decreasing after the 2nd and 3rd challenge. The lesional evolution after challenge showed intra- and perigranulomatous infiltrations with alkaline-phosphatase positive lymphocytes and plasma cells. The density of the intragranulomatous reticulin network developed after the hypersensitivity reactions increased progressively and was morphometrically assessed as statistically significant. Cellular and fibrillar lesions led to the restructuring of the lung tissue.

Animals↗
PubMedDate not supplied

[Volvulus of the gallbladder].

An observation is presented concerning a volvulus of the gallbladder, a rare cause of acute abdomen. This affection is mostly encountered in aged people or in those with various background diseases, and its development is favoured by the presence of congenital malformations, visceral ptoses, or by exaggerated intestinal peristaltism. The preoperative diagnosis is only exceptional and indications for surgical intervention are made on the basis of signs suggesting peritoneal irritation, or the presence of a "tumor" in the right flank. Cholecystectomy, facial in most of the cases is followed by full recovery in all the cases when the intervention is performed at an early stage.

Abdomen, Acute↗
PubMedDate not supplied

Isolation of parainfluenza virus type 3 from an infant with meningoencephalitis.

A parainfluenza virus type 3 strain was isolated from the cerebrospinal fluid of an infant with a clinical diagnosis of meningoencephalitis. Specific HAI antibodies to parainfluenza virus type 3, ranging in titer from 1/80 to 1/160 could be detected in the infant's serum. A 2-fold rise in the level of complement fixing serum antibodies-from 1/16 at the first to 1/32 at the second collection-was recorded.

Antibodies, Viral↗
PubMedDate not supplied

Gastrin cells in stomach and duodenal ulcers.

By means of cytochemical and electron microscopy methods, the behavior of gastrin cells in ulcers of the stomach and duodenum were investigated. The study was performed on specimens of surgical resection from stomach and duodenal ulcers with gastric normacidity. The results point out a significant decrease of gastrin cells in stomach ulcers in comparison with the duodenal ones. These findings in stomach ulcers were attributed to the high intensity of gastritis lesions, histopathologically evidenced. Electron microscopy revealed that gastrin cells were loaded with secretion granules presenting suggestive images of synthesis activity.

Duodenal Ulcer↗
PubMedDate not supplied

[Formolization of the bladder mucosa for hemostatic purposes].

The authors have used formalin solutions for the control of haematuria induced by bladder tumours. The 10 percent solution was efficient but induced severe side effects, such as peritonitis due to vesical necrosis, urethral fistulae, etc. The 1 percent solution is also efficient, and the local aggressivity is practically lacking, provided only 1--3 applications are carried out. The method should be used only in cases of haematuria that cannot be stopped by classical conservative means and in which surgery is not indicated, either temporarily or definitively.

Aged↗
PubMedDate not supplied

Bronchiolar pathology. IV. a morphometric analysis of the incidence and location of lesions induced in rabbits by intratracheally injected detergent solutions.

An experimental model of bronchiolar lesions was elaborated. It consisted of three intratracheal administrations in rabbits of 2 ml of a 3 per cent detergent solution, pH 2.5-3; the adequate development of the process was induced when the second injection was given 48 h after the first and the third on days 5-6. The induced process evolved during three phases: a) hypertrophy with hyperfunction of Clara cells, cell beheading by apo- and merocrinia and denudation of basement membranes; b) lesions of subepithelial components, mainly of capillaries, with granulative response and restructuration of the peribronchiolar tissue, and c) tardy regenerative response of epithelial cells, sometimes with neoformation of bronchioli. The morphometric analysis of this experimental process asserted the validity of the model which led to damages involving at less 70 per cent of the bronchioli (under 200 epithelial nuclei on a circumferential section) and of the small bronchi (with 200-500 epithelia nuclei); the other small and large bronchi were never involved. The morphometric analysis also showed the relations of the intervals between injections to the lesional intensity and stereotyping.

Animals↗