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Biomedical subjects

E Peters

Publications and source records attributed to E Peters.

120 records · Page 7Linked to original sources
PubMedDate not supplied

Malignant neuroendocrine tumor presenting in the mandible.

The carotid body, jugulotympanic, vagal, and laryngeal paragangliomas are the most common paragangliomas respectively within the head and neck, although unusual examples in other sites have been described. Among these are several references in the literature to a mandibular or "alveolar body" paraganglioma, even though such an entity does not appear to have been adequately documented. This report describes a case which presented as an extensive osteoblastic tumor involving the mandible and which radiographically appeared as a typical osteosarcoma. However, the immunohistochemical and electron microscopic features were of a neuroendocrine tumor and the histologic pattern suggested a paraganglioma. The tumor was nonfunctional and an extensive search failed to reveal any further lesions. Eight months after resection of the lesion, metastatic deposits appeared within the left iliac crest and lumbar vertebra. The origin of this tumor is discussed.

Aged↗
PubMedDate not supplied

Primary or established liver cells for a hybrid liver? Comparison of metabolic features.

It is currently in discussion whether or not established liver cell lines can be used for an extracorporeal liver assist device. Thus, metabolic features of primary hepatocytes, immortalized hepatocytes, and hepatoma cells were compared. The ability of these cells to process toxic blood of patients with hepatic failure was investigated by testing their viability in toxin enriched medium that was obtained by toxin separation from patients' blood via a molecular adsorbents recirculating system (MARS). In addition, glucose metabolism, urea synthesis, P450 dependent verapamil metabolism using high performance liquid chromatography, and interleukin-6 induced "acute phase" reaction by sulfodesoxysalicylic acid-polyacrylamide gel electrophoresis detected changes of albumin synthesis were determined in primary hepatocytes and in established liver cells. The viability of hepatoma cells after contact with the toxic compounds coming from the patients' blood was significantly decreased in comparison to that of immortalized hepatocytes and primary hepatocytes. Immortalized hepatocytes and hepatoma cells showed a significantly higher consumption of glucose associated with a significantly higher lactate synthesis. A basic urea synthesis rate could be measured in immortalized hepatocytes and hepatoma cells, but it was significantly lower than that of primary cells. P450 with its subenzyme CYP2C was inducible only in primary hepatocytes and in immortalized cells, but in the latter the enzymatic activity was lower than that of primary cells. The incubation with acute phase mediators resulted in a decrease of albumin synthesis in primary hepatocytes and in hepatoma cells, but it increased the albumin synthesis in immortalized hepatocytes. Summarizing these data, partially beneficial effects can be assumed if established cells are used in an extracorporeal liver assist device. These might include synthesis of some compounds and basic metabolic activities, such as urea synthesis. However, established liver cells showed clearly altered metabolic characteristics. The sufficient removal of toxic compounds requires additional strategies for detoxification by primary hepatocytes in sufficient amounts.

Acute-Phase Reaction↗
PubMedDate not supplied

Immunogenetic studies of multiple sclerosis patients in Caithness County, Scotland.

The present report indicates that there is an increased frequency of HLA-B7 in multiple sclerosis patients compared to unrelated controls and unaffected siblings. HLA-A3 was not significantly increased. The increased frequency of certain HLA antigens was not reflected in increased titres of serum measles antibodies in this group. In contrast to our previous studies, there were only minimal differences in the cellular response to measles antigen in multiple sclerosis patients as compared to siblings and unrelated controls.

Adult↗
PubMedDate not supplied

Bilateral congenital oral mucous extravasation cysts.

This report documents the bilateral presentation of oral mucous extravasation cysts on the left mucobuccal fold and right buccal mucosa of a neonate. The lesions were noted at birth and subsequently enlarged to the point that they interfered with eating. The left lesion ruptured but persisted as an exophytic fibrotic mass. Both lesions were surgically removed at eight months and the diagnosis was confirmed by histopathologic examination. Post-operative follow-up after nine months shows no recurrence. The presentation and diagnostic considerations are discussed.

Biopsy↗
PubMedDate not supplied

Disturbing effects of low frequency sound immissions and vibrations in residential buildings.

Noise immissions with predominant low frequency sound components may exert considerably disturbing effects in dwellings. This applies in particular to sounds which are excitated by transmission of structure-borne noise, and to low frequency sounds emitted by ventilators. Exposed persons usually declare such immissions as being "intolerable" even at very low A-weighted sound levels. If mechanical vibrations in the frequency range below 20 Hz (ground-borne vibrations) affect dwelling rooms, the annoying effects are perceived only by a small portion of exposed individuals as a physical effect. For the most part the immissions are observed as vibratory effects on the building and on objects inside the dwelling. The disturbing effects of vibration frequencies above 20 Hz (structure-borne sound) are determined by the airborne sound field generated inside a particular room and its given surface and extension.

Housing↗
PubMedDate not supplied

A template for cultural diversity workshops.

PURPOSE/OBJECTIVES: To present a model for a series of workshops designed to improve the ability of oncology nurses to understand and fulfill culturally based needs of racially and ethnically diverse patients with cancer. DATA SOURCES: Published literature and author experience. DATA SYNTHESIS: Most nurses work with patients from a variety of ethnic or cultural backgrounds yet know little of how this affects patients' cancer experiences. Four workshops were presented that focused on the most common ethnic groups in the geographic area. A content template was developed that worked well to ensure complete topic coverage. CONCLUSIONS: Workshops were well-received. Nurses identified barriers to care and interventions that are appropriate for diverse patient populations. The follow-up survey indicated that some anticipated program outcomes may not be feasible if attendees do not regularly work with target populations. IMPLICATIONS FOR NURSING PRACTICE: The model can be modified for use in any geographic area. Such workshops should be repeated at regular intervals.

Black or African American↗