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Biomedical subjects

E Pascali

Publications and source records attributed to E Pascali.

33 records · Page 2Linked to original sources
PubMed1986

Serum and urine monoclonal immunoglobulins in malignant non-Hodgkin's lymphoma.

62 consecutive patients with newly diagnosed malignant non-Hodgkin's lymphoma (NHL) were investigated for the presence, type, and amount of serum and urine monoclonal immunoglobulin abnormalities. The overall incidence of monoclonal gammopathy (MG) was 81%. M components of the IgM and IgG classes were found in the serum of 52% of the patients. Their concentration was below 10 g/l in 54% of cases and above 20 g/l in 26% of cases. The highest incidence of serum M components (75%) was seen in plasmacytoid lymphocytic lymphoma (PLL) and the lowest (38%) in follicular center cell lymphoma. A monoclonal free light chain, i.e., Bence Jones protein (BJP), was documented in the urine of 61% of cases with a daily excretion comprised between 0.01 and 9.24 g. The isolated urinary excretion of BJP was a major finding accounting for 36% of all MG found in association with NHL. It occurred in all histopathological subtypes with a frequency ranging from 17% of PLL to 37% of small lymphocytic lymphoma.

Adult↗
PubMed1984

'Senile' myeloma: a possible variant form of multiple myeloma.

Fifty-four patients were recognized as having multiple myeloma after the coincidental finding of a serum and/or urine M component on agarose gel electrophoresis during a survey for monoclonal gammopathies of a large random hospital population sample over 70 yr of age. Analysis of the presenting features and the clinical characteristics revealed that about two-thirds of the myeloma patients over 80 yr were asymptomatic at the time of the discovery of their monoclonal gammopathy. Follow-up studies and serial evaluations of changes in the myeloma cell mass without chemotherapy showed a subset of the older patients exhibiting a distinct pattern of slow tumor growth. The results of the study would suggest the possible existence of a variant form in the advanced age group of myeloma patients. This 'senile' type of myeloma would appear to be characterized primarily by non-specific presenting features, a fairly symptom-poor status, and a relatively protracted and benign course without chemotherapy.

Aged↗
PubMed1981

'Bis'-fibrinogenaemia.

During routine investigation of plasma proteins by agarose gel electrophoresis, a double fibrinogen band was found in a 79-year-old woman without previous history or clinical symptoms of bleeding tendency. The finding was not associated with prolonged thrombin clotting time, and other routine coagulation tests gave normal results. The plasma fibrinogen concentration was normal when assayed as thrombin clottable protein and by immunological methods. The fibrinogen abnormality was not drug-induced and was apparently unrelated to liver disease. Family studies failed to confirm or exclude its genetic origin.

Aged↗
PubMed1980

Amyloid casts within renal tubules: a singular finding in myelomatosis.

This study was carried out in order to investigate a possible relationship between multiple myeloma and the occurrence of material exhibiting the properties of amyloid within renal tubules. Two groups of autopsied patients, with myelomatosis and benign monoclonal gammopathy were examined for the presence of amyloid deposits in renal and extra-renal sites. Urines were analysed for the presence and amount of Bence Jones protein and the pattern of the associated proteinuria was characterized. Renal tubular casts exhibiting the histochemical characteristics of immuno-amyloid were found exclusively in myeloma patients with Bence Jones proteinuria but without the renal lesions classically described as "myeloma kidney". This finding was independent of the occurrence of immuno-amyloid deposits in other renal and extra-renal sites, suggesting involvement of local factors in the pathogenesis of amyloid formation and deposition within renal tubular lumina. The results of present study suggest the conclusion that the presence of amyloid intratubular casts is to be regarded as a peculiar finding in myelomatosis.

Aged↗
PubMed1980

Pseudotumoral (para-articular) amyloidosis in non-myelomatous monoclonal gammopathy.

A case of non-myelomatous monoclonal gammopathy, with the unusual presenting features of recurrent "pseudotumoral" localized amyloid deposits in intimate relation with the shoulder joints, is described. The peculiar anatomo-clinical features, which make this case quite different from the most reported ones of amyloid arthropathy and of localized amyloidosis, are discussed. The pathogenetic implications are analyzed with special reference to the various known mechanisms, none of which seems to provide a completely satisfactory explanation of the genesis of this form.

Aged↗
PubMed1980

Incidence of paraproteinaemia in blood donors.

Paraproteinemia was detected by agarose gel electrophoresis in 13 out of 3,800 apparently healthy blood donors of an Italian district. None of the subjects with a serum M component developed overt B cell malignancy over a prolonged period of observation. The incidence of paraproteinaemia was higher than that reported from previous surveys of similar populations of blood donors in other European countries, possibly due to the sensitivity of the technique adopted for the screening investigation. The main implications of the detection of monoclonal immunoglobulin abnormalities are briefly discussed with particular reference to the possible indications for routine screening of blood donors for the presence of paraproteins.

Adolescent↗
PubMed1980

Nodular lymphoma eventuating into lymphoplasmocytic lymphoma with monoclonal IgM/lambda cold agglutinin and Bence-Jones proteinuria.

A case of nodular lymphocytic (centroblastic/centrocytic) lymphoma that developed within 5 months after the initial diagnosis of lymphoplasmocytic lymphoma is described. The change in the histopathological picture, consisting of the development of a functionally more differentiated B cell neoplasm, occurred in the abdominal lymph nodes while the original pattern persisted in the bone marrow, liver and spleen. The patient was also found to have a serum IgM/lambda monoclonal immunoglobulin exhibiting cold agglutinin activity with specificity for the 'non-I' erythrocyte antigens.

Agglutinins↗
PubMed1979

[Detection of paraproteinemia in blood donors. Results of systematic analysis of 3800 donors in Trieste].

A systematic analysis of plasma protein pattern performed by agarose gel electrophoresis has detected paraproteinemia in 13 out of 3800 blood donors in the district of Trieste. The variations in the incidence of monoclonal gammopathies in surveys of blood donors could be related not only with geographical origin and the age and sex distribution of the population studied but also with the sensitivity of the screening technique employed. The physiopathological and clinical implications of the detection of paraproteins favour the inclusion of the screening plasma electrophoretic analysis among the laboratory investigations for blood donors.

Adolescent↗
PubMed1976

[Considerations about the physiopathological and clinical significance of the oligclonal serum pattern (author's transl)].

The fortuitous report of the change of serum electrophoretic pattern from the oligoclonal to the monoclonal type in a patient with Hodgkin's disease has been the starting point for some considerations about the physiopathological and clinical significance of the oligoclonal serum pattern. The AA. carry out a critical review of the ordinary electrophoretic methods, underlining some problems related to a good visualization of the oligoclonal serum pattern.

Adult↗
PubMedDate not supplied

[CT angiography for the evaluation of adult orthotopic liver transplantation arterial complications].

PURPOSE: In this study we compared duplex Doppler sonography, conventional angiography and CT angiography for the evaluation of hepatic arterial complications following orthotopic liver transplantation (OLT). MATERIAL AND METHODS: CT angiography, with Maximum Intensity Projection (MIP) and Volume Rendering reconstructions, was performed in 11 patients with well-grounded suspect of hepatic artery stenosis or thrombosis after routine duplex Doppler examination. Eight patients underwent conventional angiography. RESULTS: CT detected three out of four duplex doppler false positives and confirmed the diagnostic suspect in four cases. In two cases it showed a shift of the blood flow towards the splenic artery with hepatic hypoperfusion. In one case a wrong delay rendered the study unuseful. In seven out of eight patients conventional angiography confirmed CT angiography findings. DISCUSSION. The follow up of OLT arterial complications is now performed with duplex doppler sonography; this technique has a satisfactory sensitivity and specificity, but far from 100%. Therefore in some patients the diagnosis of arterial obstruction might be delayed, with the risk of serious complications; in other cases with ultrasonographic false positive findings, useless angiographic examinations are performed. In our experience CT angiography proved to be a precious tool, which might be included in the diagnostic algorithm of arterial complications after OLT. Particularly CT angiography seems to be suitable for the cases of discordance between clinical and duplex doppler findings, to improve the overall diagnostic accuracy. CONCLUSION: In our experience CT-angiography proved to be accurate and satisfactory as a second step examination after duplex-doppler in the diagnostic algorythm of adult OLT arterial complications.

Adult↗
PubMedDate not supplied

Serum and urinary monoclonal immunoglobulins in Hodgkin's disease. Report of two cases.

Two patients with histologically unequivocal Hodgkin's disease (HD) (lymphocyte-depleted type, stage IIIA, and mixed cellularity variety, stage IVA) were found to have, respectively, a serum IgGk M-component and pure Bence Jones proteinuria of the lambda type. Unlike most of the previously reported patients with HD-associated monoclonal gammopathy (MG), they had simultaneous occurrence of HD and M-components, and no evidence of concurrent multiple myeloma or any other related B-lymphoproliferative disorder was found either at presentation or at postmortem examination. Both M-components were demonstrated before starting any cytotoxic treatment, and their appearance was unrelated to other disorders which may be associated with persistent antigenic overstimulation. In both patients the size of the M-components was reduced significantly by treatment for HD. Such findings make these patients of interest for exploring the significance of the coexistence of HD with MG.

Aged↗