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Biomedical subjects

E Pasargiklian

Publications and source records attributed to E Pasargiklian.

At least 19 recordsLinked to original sources
PubMed1984

Evaluation of plasma iodothyronines in various stages of pregnancy.

Evaluation of thyroid status during the whole normal pregnancy was carried out by measuring serum total thyroxine (TT4), total 3,5,3' triiodothyronine (TT3), T3 resin uptake (T3(U)), 3,3',5' triiodothyronine (rT3), free thyroxine index (FTI), free thyroxine (FT4) and thyrotrophin (TSH) in 70 serum samples from 42 pregnant women being in a variable period from the 6th to the 40th week of pregnancy and in 14 serum samples from 14 non pregnant healthy women. The serum samples were divided in 7 groups, according to the gestational age of the subjects. Every group was formed by 10 samples collected within the same five weeks period. The levels of TT4, TT3, T3 (U) and rT3 were found significantly elevated during pregnancy, above the levels of the control group (p less than 0.01); the increase is very early. FTI remained in the range of normal non pregnant subjects without any significant change in all groups studied. FT4 concentration showed a progressive downward trend with gestational age. This fall became significant in the second group (11th to 15th weeks), when compared to the levels of non pregnant women (p less than 0.01) TSH mean values remained in the normal range within the three trimesters, though they showed some fluctuations.

Adult↗
PubMed1984

Effect of estrogens on luteinizing hormone release in testicular feminization syndrome before and after gonadectomy.

The effect of exogenous estrogens on luteinizing hormone release was studied in three siblings with complete testicular feminization syndrome. Two subjects, 21 and 20 years old, were postpubertal. The third, 15 years old, was in the early pubertal stage. An estrogen provocation test was performed in which 20 mg of conjugated estrogens were administered intravenously and serum follicle-stimulating hormone and luteinizing hormone levels were assessed every 12 hours for 96 hours under basal conditions, on day 5 of an eight-day treatment with 0.2 mg/day ethinyl estradiol orally, and on day 5 of a subsequent eight-day treatment with 0.2 mg/day ethinyl estradiol and 120 mg/day cyproterone acetate orally. The first two tests were repeated one month after gonadectomy. During pregonadectomy treatments there was an overall luteinizing hormone fall. After gonadectomy, the two postpubertal subjects exhibited luteinizing hormone surges during ethinyl estradiol treatment -in one as a single peak and in the other as multiple peaks. A positive feedback effect was not induced in the youngest patient either before or after gonadectomy as in normal prepubertal and early pubertal females. The data suggest that testosterone or some other testicular factor inhibits estrogen induced positive feedback for luteinizing hormone. This inhibition mechanism acts independently of the testosterone cytosol receptor.

Adolescent↗
PubMed1983

Endocrine study of anorexia nervosa.

The main objective of the study was to evaluate the endocrinological picture of anorexia. The sample consisted of 23 anorectic patients (20 females, 3 males) with a control group of 10 normal females and 5 normal males. All participants underwent a work-up which included testing for hypothalamic, hypophyseal, thyroidal, adrenal, gonadal functioning and glucose metabolism. Our results revealed a reduced urinary output and low serum levels of gonadotropins with different responses to LHRH correlating with the stage of the illness. We found reduced urinary estrogens and elevated testosterone levels in females. Males demonstrated a reduction of testosterone. While basal prolactinemia was normal in both sexes, males showed an exaggerated response to TRH. The thyroid function study in anorectic patients revealed a decrease in T3 and in free T3 and an increase in reverse T3. Free T4 was slightly increased with normal T4 levels. Basal TSH was normal with a delayed peak after TRH. We also noticed in the anorectic population reduced basal glucose levels with a flat glucose curve; reduced insulin levels with a slight increase after glucose administration; elevated basal GH with a fair response to L-Dopa; elevated serum cortisol with loss of circadian rhythm and slightly inhibited by dexamethasone. In addition, both noradrenalin and VMA were reduced. We concluded that the multiple endocrine abnormalities found are consistent with hypothalamic dysfunction. The etiology of this dysfunction remains for the endocrinologist highly controversial.

Adolescent↗
PubMed1983

Thyroid function in altered nutritional state.

We studied plasma concentrations of TSH (basal and after TRH), thyroxine (T4), 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (reverse T3; rT3), free T4 and free T3 in thirty obese subjects, twenty patients with anorexia nervosa, fifteen malnourished subjects and twenty normal weight subjects. Total serum T4 values were similar for the four groups of subjects while serum free T4 values were slightly increased in anorexia nervosa and normal in the other groups. Serum total and free T3 levels were both significantly decreased in anorexia nervosa and malnutrition, and within normal limits in obesity. The mean serum rT3 level was increased in anorexia nervosa and malnutrition while was reduced in obesity. A delay in peak response of TSH to TRH stimulation (30' rather than 20') was noted in anorexia and malnourished patients. The results suggest that these alterations of serum iodothyronines are due to a different peripheral conversion of T4 to T3 according to nutritional status.

Adolescent↗
PubMed1978

Comparative studies in two cases of testicular feminization syndrome, one with and the other without the fluorescent distal band q12 of the Y.

In two patients with testicular feminization syndrome, one Yq12-positive and the other Yq12-negative, we compared phenotype, gonadal histology and ultrastructure, in vivo steroid response of the testes to the administration of exogenous gonadotropin during adrenal suppression, and of the adrenal gland to ACTH. The assumption that the constitutive Y heterochromatin could function as a regulator of steroid biosynthesis and metabolism, with or without effect at other levels, was not firmly supported by the observations reported here. However, further studies along this line may help elucidate the biologic role of this portion of the Y chromosome in humans.

Adrenal Glands↗
PubMed1975

Thyroidal accumulation of 131I during adrenal gland scintigraphy with 131I-19-iodocholesterol: effects of thyroid blocking agents.

131I-19-iodocholesterol has been used by Beierwaltes et al., to visualize human adrenal glands. The tissue distribution of 131I-19-iodocholesterol was determined by Morita et al., both in dogs and men. No data have been reported on thyroidal 131I accumulation after administration of the radiopharmaceutical. We calculated the percentage uptake of radioactivity in the human thyroid gland inhibited with various therapeutic agents (triiodothyronine (T3), Lugol's solution, potassium perchlorate (KC1O4).

Adrenal Gland Diseases↗