Search PubMed⌕ Search

Biomedical subjects

E Palacios

Publications and source records attributed to E Palacios.

At least 37 records · Page 2Linked to original sources
PubMed2000

Magnetic resonance imaging of the internal auditory canal.

Magnetic resonance imaging (MRI) is presently the study of choice for assessment of the internal auditory canal (IAC). MRI provides excellent assessment of the IAC and the bony changes occurring in the canal walls, and it provides excellent demonstration of the content of the canal. Pathological processes arising within the IAC are well visualized by various MR sequences. The possibility of demonstrating masses as small as 2 mm has propelled MRI into the leading role for diagnosis of vestibular schwannoma. Unfortunately, the high cost of MR has been a limiting factor in its use as a screening test for patients with sensorineural hearing loss (SNHL) of unknown origin. Auditory brain stem response has been widely used as a screening procedure, but this test fails to recognize small lesions and cannot be used whenever hearing loss is severe. In this article, we will discuss our approach to assessment of the IAC in patients with retrocochlear SNHL or vestibular symptoms of central origin, review the pathological processes involving the IAC walls or arising within the canal, emphasizing the appropriate MRI sequences used for diagnosis.

Ear Diseases↗
PubMed1999

Modulation of triglyceride metabolism by glucocorticoids in diet-induced obesity.

The involvement of glucocorticoids (GC) in the development of diet-induced obesity and in the concomitant adaptations of triglyceride (TG)-rich lipoprotein metabolism were examined. Rats were fed either rodent chow, which maintains a low lipid flux, or a diet high in sucrose and fat (HSF) that increases lipid flux, leading to metabolic perturbations similar to those that define the plurimetabolic syndrome in humans. The GC status was manipulated through adrenalectomy (ADX) and corticosterone (Cort) replacement. Compared with chow, the HSF diet increased energy intake (17%) and whole body (8%) and adipose tissue (80%) weights. The HSF diet also increased the acute postprandial rise in plasma insulin (4-fold) and TG (3-fold), fasting liver TG content (3-fold), triglyceridemia (54%), and adipose tissue lipoprotein lipase (LPL) activity (2-fold). ADX decreased energy intake and whole body and adipose tissue weights in both dietary cohorts, but more so in HSF-fed than in chow-fed animals. These ADX-induced effects were totally prevented by Cort replacement in rats fed chow, but only partially so in those fed the HSF diet in proportion to the degree of restoration of energy intake. In the chow-fed cohort, the above indexes of TG metabolism remained unaffected by the Cort status, whereas in the HSF-fed cohort, these variables were decreased by ADX to levels of chow-fed animals. Cort replacement in the HSF-fed animals restored indexes of TG metabolism to intact levels and reestablished the diet-related differences observed in intact animals. These findings indicate that GC modulate fasting TG metabolism only minimally when a diet that maintains a low lipid flux is fed. In contrast, their presence is a necessary condition for the development of diet-induced obesity and the concomitant alterations in insulin sensitivity and TG-rich lipoprotein metabolism.

Adipose Tissue↗