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Biomedical subjects

E Paice

Publications and source records attributed to E Paice.

At least 37 records · Page 2Linked to original sources
PubMed1986

Autonomic neuropathy in systemic sclerosis: a case report and evaluation of six patients.

We describe a case of systemic sclerosis with sympathetic and parasympathetic neuropathy and detail autonomic testing in six further patients. Of these six patients, three showed early parasympathetic damage. None of the patients had evidence of peripheral neuropathy, and there was no correlation between the presence of autonomic dysfunction and the severity of Raynaud's phenomenon.

Adult↗
PubMed1984

An immunohistological study of secondary Sjögren's syndrome.

The labial biopsies from 13 patients with secondary Sjögren's syndrome (SS) and four disease controls were examined with a panel of monoclonal antibodies to human leucocyte antigens. Large numbers of T cells were found in most of the biopsies. In seven SS patients the T helper/inducer subset was found to be predominant. Antibody to HLA class I antigens consistently stained leucocytes, but other cell types stained more variably. Although the staining with antibody to HLA class II antigen was often weak, approximately as many cells stained with this antibody as with an antileucocyte antibody, implying that the T cells were activated. Anti-IgD revealed membrane staining of a corona of IgD-positive cells in structures resembling germinal centres. Isolated cells throughout the sections also showed strong cytoplasmic staining with anti-IgD. These results suggest a role for T-cell-dependent local antibody synthesis in the pathogenesis of the disease.

Adult↗
PubMed1983

The use of C3d as a means of monitoring clinical activity in systemic lupus erythematosus and rheumatoid arthritis.

Plasma samples from 44 patients with systemic lupus erythematosus (SLE) and 43 with rheumatoid arthritis (RA) were assayed for C3d, a breakdown product of the third component of complement (C3), which was also measured in parallel. Levels of C3d varied in direct proportion with disease activity in RA, whereas C3 showed little change. Although C3d values also increased with worsening clinical condition in SLE, this trend was not considered to be sufficiently clear to be useful and did not provide any advantage over the routinely performed C3 assay.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Senior house officer training: are overseas graduates treated differently?

In a survey of senior house officers' (SHOs') satisfaction with training, overseas graduates rated their posts at least as highly as British graduates. Overseas graduates were older, more experienced and more likely to be training in district general hospitals.

Foreign Medical Graduates↗
PubMedDate not supplied

A charter for house officers.

Recently there have been several initiatives to improve the working conditions and training of junior doctors. However, monitoring is infrequent considering the rapid changes in the health service, thus a mechanism to detect early problems is necessary. With this in mind, we have drawn up a charter for house officers that outlines standards which they should expect and the action they should take if they are not met.

Education, Medical, Continuing↗
PubMedDate not supplied

Future training of hospital doctors.

Many changes are occurring in the organization and management of postgraduate medical education and training. Hospital Doctors: Training for the Future (Department of Health, 1993) highlights the need for shorter training programmes and structured curricula. A number of issues still require analysis, particularly the resource implications of expanding the consultant grade.

Costs and Cost Analysis↗
PubMedDate not supplied

On-site modular management training for junior doctors.

A structured, modular management training programme has been developed to introduce junior doctors to basic management skills and concepts, successfully improving the efficiency of the organization.

Education, Medical, Continuing↗