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Biomedical subjects

E Padilla

Publications and source records attributed to E Padilla.

50 records · Page 3Linked to original sources
PubMed1992

Endothelin-1 is an autocrine factor in rat inner medullary collecting ducts.

Endothelin-1 (ET-1) may be an important factor in the regulation of inner medullary collecting duct (IMCD) physiology. This segment of the nephron synthesizes ET-1, expresses endothelin receptors, and responds to exogenous ET-1 by reducing Na(+)-K(+)-ATPase activity and water transport. Taken together, these findings suggest an autocrine role for ET-1 in the regulation of IMCD function; however, because of the polarized nature of the IMCD, it is not known if ET-1 secretion, receptors, and receptor activation occur on the same side of the cell. To examine this question, rat IMCD cells were grown to confluence on semipermeable membranes. These cells exhibited polar morphology with high transepithelial electrical resistances. Immunoreactive ET-1 was secreted primarily into the basolateral side. Furthermore, 125I-ET-1 bound predominantly to the basolateral surface. Finally, ET-1 (10(-8) M) stimulated prostaglandin E2 production only when added to the basolateral side. These data indicate, therefore, that ET-1 is capable of autocrine regulation of IMCD cells and that this effect occurs predominantly on the basolateral side.

Animals↗
PubMed1977

MMPI differences among black, Mexican-American, and white male offenders.

MMPI scores of black, Mexican-American, and white male offenders were compared in order to investigate whether cultural and/or socioeconomomic factors affect this personality inventory. Comparisons were performed on unmatched and matched (education and occupation) groups that utilized all profiles or valid ones only and examined both trait (individual scales) and type (Goldberg indices) differences. Black-white differences on the MA, K, and HY scales appeared to reflect cultural factors, while differences on MF and alcoholism seemed to be accounted for by socieconomic differences among the groups. Cultural factors seemed to be related to differences between Mexican-Americans and white on the L,K,and overcontrolled hostility scales, while socioeconomic factors appeared to explain differences on the Hs scale. Type differences were not apparent except that Mexican-Americans were classified more often as psychiatric, while whites and blacks scored well into the sociopathic range.

Adult↗
PubMedDate not supplied

Lipoprotein profiles and their relation to animal fat intake in healthy old people from four Spanish localities.

In studies carried out on 401 individuals from different Spanish regions, blood lipoprotein levels do not show a clear relationship to amounts of animal fat intake because diet habits change in old age. But in these persons there was a significant and positive correlation between actual LDL levels and animal fat intake when they were 40-45 years old. Similar results are obtained with HDL, but correlations are inversely proportional. Our study leads to the interpretation that diet habits during the first phase of the adult life span are determinant for the lipoprotein profiles in older ages, which can still be observed in very old individuals.

Adult↗
PubMedDate not supplied

[Evoked potentials in the sacred baboon: long-term follow-up of intracerebroventricular infusion of nerve growth factor].

INTRODUCTION AND OBJECTIVE: It is well known that in aged animals cognitive deficit occurs, homologous with that occurring in Alzheimer's disease in humans, and as has been shown in others species, this may be attenuated by administration of nerve growth factor (NGF). Therefore the basic aim of this study was to make an electrophysiological evaluation of the repercussion that there might be after long-term administration of this neurotropin in the sacred baboon (Papio hamadryas) comparing aged with young animals. MATERIAL AND METHODS: We studied a six year old male and a 39 year old female, after sedation. Long-term intraventricular administration of NGF was carried out using a continuous infusion pump, at a dose of 2.1 micrograms/kg/day. Recordings were made before installing the pump and 1, 3 and 6 months after insertion. A Neuropack Four-mini set for evoked potentials (Nihon Kohden) was used to record auditory evoked potentials from the brain stem and visual evoked potentials due to flash. RESULTS AND CONCLUSION: In both animals there were modifications of their electrophysiological responses. These reached a maximum after one month, more markedly in the older animal and this could possibly be related to the neuromodulator effect of NGF.

Animals↗