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Biomedical subjects

E P Volpe

Publications and source records attributed to E P Volpe.

At least 19 recordsLinked to original sources
PubMed1979

Clarification of studies on the origin of thymic lymphocytes.

The thesis that lymphocytes originate in situ by the direct transformation of epithelial cells within the thymic primordium in anurous frogs is untenable. On the contrary, in both the leopard frog and the African clawed toad, the lymphocytes that first appear in the embryonic thymus are derived from extrathymic lymphopoietic cells that invaded the developing organ. The exact source of origin of the invading lymphopoietic cells remains problematic.

Animals↗
PubMed1975

Thymus: central role in the immune system of the frog.

In the leopard frog (Rana pipiens), the thymus profoundly influences immunologic development by providing virtually all the progenitor lymphocytic cells for the bone marrow and other peripheral lymphoid organs. The thymus houses a self-perpetuating population of lymphopoietic cells that originally self-differentiated in that gland.

Animals↗
PubMed1973

Ontogeny and peripheralization of thymic lymphocytes.

Reciprocal transplantation of undifferentiated thymic primordia between diploid and triploid chromosomally marked frog embryos has revealed that thymic lymphocytes are ontogenically derived from elements of the thymic primordium rather than from blood-borne stem cells that migrated into the developing organ. Virtually all the lymphocytes in the spleen, kidneys, and bone marrow of adult frogs are descendants of these original thymic stem lymphocytes.

Animals↗
PubMed1968

Frog germ cells.

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Animals↗