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Biomedical subjects

E Ofstad

Publications and source records attributed to E Ofstad.

At least 19 recordsLinked to original sources
PubMed1990

[Cancer of the pancreatic head and the periampullary region].

Between 1976 and 1988, 16 patients underwent a Whipple resection or total pancreatectomy for carcinoma of the head of the pancreas, the ampulla of Vater or the distal common bile duct. Nine patients had carcinoma of the pancreas. Two of these patients are long-term survivors. The tumors in these patients were highly differentiated and localized close to the common bile duct. Four had ampullary lesions, and are all alive today. Three patients had carcinoma of the common bile duct. One of these patients is alive.

Aged↗
PubMed1982

A single dose tinidazole and doxycycline prophylaxis in elective surgery of colon and rectum. A prospective controlled clinical multicenter study.

Antimicrobial prophylaxis with agents active against aerobic and anaerobic micro-organisms leads to a significant reduction of infectious complications following colorectal surgery. A single dose (1600 mg) of tinidazole (a nitroimidazole derivate) and doxycycline (400 mg) will provide serum and tissue values well above minimum inhibitory concentration (MIC) values for more than 24 hours. To reduce the unwanted side effects and cost of prolonged antimicrobial prophylaxis, a prospective controlled clinical multicenter study comparing the effect of a single dose before operation of tinidazole and doxycycline to five days of prophylaxis before operation in 234 patients undergoing elective colorectal surgery was undertaken. Six patients given a single dose of prophylaxis before operation (n = 118) developed infectious complication (5.1%). Prolongation of prophylaxis before operation for four days after operation (n = 116) did not lead to any further reduction of infectious complications. A single dose of tinidazole and doxycycline before operation is a simple and effective prophylaxis against infectious complications following elective colorectal surgery.

Adolescent↗
PubMed1980

Tinidazole and doxycycline as antimicrobials in elective colorectal surgery. A randomized multicentre trial.

A prospective randomized study on the effect of doxycycline alone, tinidazole alone and the two antimicrobials in two different combinations as prophylactic antimicrobials on elective colorectal surgery is presented (Table II). The number of patients included in the study was 265. Of the four different treatment groups, the one which consisted of a single preoperative dose of tinidazole 2 g and doxycycline 200 mg, seemed to give the most favourable result. In this treatment group (n = 70), wound sepsis was recorded in 7.2% and perineal sepsis in 34.8% of the cases. Only one serious, but non-fatal intra-abdominal complication (1.4%) was observed in this group. The trial did not include a placebo group.

Aged↗