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Biomedical subjects

E Newbrun

Publications and source records attributed to E Newbrun.

At least 37 records · Page 2Linked to original sources
PubMed1991

Electroencephalographic changes and periodontal status during short-term vitamin B-6 depletion of young, nonpregnant women.

As part of a larger investigation to determine the effect of animal vs. plant proteins on the vitamin B-6 requirement of young women, clinical changes during vitamin B-6 depletion were documented. Eight healthy young women were confined to a metabolic unit and fed a defined formula diet nearly devoid of vitamin B-6 (less than 0.05 mg/d). Serial electroencephalographic (EEG) tracings, peripheral nervous system tests, periodontal evaluations, and biochemical measures of vitamin B-6 status were conducted. Within 12 d on the depletion diet, two of the eight women exhibited abnormal EEG tracings. These changes were readily reversed by repletion of vitamin B-6 at the 0.5-mg/d level. Biochemical measures reflected lowered vitamin B-6 status but were not predictive of the onset of EEG changes. No detectable alterations in oral or periodontal status were found, nor did plaque flora change markedly. This study is the first report of EEG changes occurring in women undergoing vitamin B-6 depletion and the first report to document EEG changes in adults within 12 d on a vitamin B-6-depletion regimen.

Adult↗
PubMed1989

Frequent sugar intake--then and now: interpretation of the main results.

The Vipeholm Study is a unique diet-caries interventional study that has earned its place as a citation classic. One of the findings, that quantity of sugar consumed at meals in a non-sticky form had little influence on caries rate, has often been misinterpreted, as it is based on an institutional population under supervised dietary control. The other main finding, that sugary foods consumed in a sticky form at high frequency between meals are highly cariogenic, is generally accepted. Although the Vipeholm Study has been criticized on ethical grounds, relatively fewer teeth were extracted for caries than are currently extracted in an adult population. The results of two modern studies in Northumberland, UK, and Michigan, USA, on the relationship between dietary habits and caries increments in children have been compared with the Vipeholm findings. Currently the correlations between dietary habits and caries increments are low because of the low caries increments and relatively small differences in dietary patterns in non-interventional conditions. High frequency of snacking is uncommon and use of topical fluoride agents (dentifrices, rinses) is widespread. However, for the caries-susceptible person, between-meal consumption of sugary foods is still a risk factor.

Adolescent↗
PubMed1989

Effectiveness of water fluoridation.

The efficacy of communal water fluoridation in reducing dental caries has been reviewed based on surveys conducted in the last decade of caries prevalence in fluoridated and nonfluoridated communities in the United States as well as in Australia, Britain, Canada, Ireland, and New Zealand. The efficacy is greatest for the deciduous dentition, with a range of 30-60 percent less caries in fluoridated communities. In the mixed dentition (ages 8 to 12), the efficacy is more variable, about 20-40 percent less caries. In adolescents (ages 14-17), it is about 15-35 percent less caries. Current data on caries prevalence in adults and seniors are extremely limited and include several populations living in communities with higher than optimal fluoride levels. For these adults and seniors, a range of 15-35 percent less caries would also apply. Viewed in toto, the current data for children, adolescents, adults and seniors show a consistently and substantially lower caries prevalence in fluoridated communities. For an accurate measurement of the efficacy of water fluoridation in reducing dental caries, it is essential that only persons with a record of continuous or long-term residency in fluoridated versus nonfluoridated areas be included in such assessments. Because of the high geographic mobility in our society and the widespread use of fluoride dentifrices, supplements, and other topical fluoride agents, such comparisons are becoming more difficult to conduct. Accordingly, the effectiveness (rather than the efficacy) of water fluoridation has decreased as the benefits of other forms of fluoride have spread to communities lacking optimal water fluoridation.

DMF Index↗
PubMed1988

The effect of previous diet on plaque pH response to different foods.

In this study we investigated the effect of previous diet on the response of plaque pH to three test foods. The study population consisted of 11 dental students. Plaque pH was measured, by means of the touch electrode method, on the first two upper molars. The study was conducted at two sessions, one week apart. Subjects followed a 48-hour high-sugar diet before the first test session and a 48-hour low-sugar diet before the second test session. During both 48-hour periods, students refrained from all oral hygiene practices and fluoride utilization. At each session, three foods were ingested at one-hour intervals: cola, beer, and chocolate bar. pH measurements at baseline and at selected times after food ingestion were recorded and analyzed. Multivariate analysis of variance revealed significant independent effects of food, previous diet, and their interaction on plaque pH. After the same foods were ingested, plaque pH response after a previous high-sugar diet was significantly more acidic than after a previous low-sugar diet.

Adult↗
PubMed1987

Topical fluoride therapy: discussion of some aspects of toxicology, safety, and efficacy.

Although ingestion of an acute toxic dose of fluoride is extremely rare in dental treatments, practitioners should be familiar with the signs and symptoms and with emergency measures of treating accidental overdosage. The amount of fluoride ingested chronically from the use of self-applied topical fluoride can be reduced to safe limits by instructing parents to dispense small amounts of toothpaste for their young children and to ensure that fluoride dentifrices and mouthrinses are fully expectorated. Similarly, when custom-fitted trays are used, only minimal amounts of fluoride gels are necessary. The minimal amount of such gels that can be dispensed appears to be influenced by their viscosity. Clinical efficacy does not support a reduction in the concentration of fluoride in commercial dentifrices.

Diet↗
PubMed1986

Clinical and microbiologic effects of single-dose metronidazole or scaling and root planing in treatment of adult periodontitis.

Sites affected with adult periodontitis were observed for 3 months to compare their clinical and microbiologic responses to a single 2 g dose of metronidazole, scaling and root planing, or no treatment. 2 sites with probing depths greater than or equal to 5 mm in each of 18 female subjects (6 in each treatment group) were evaluated clinically (plaque and bleeding indices, probing depth, attachment loss) and microbiologically (%s of cocci, motile rods, non-motile rods and spirochetes, and of obligate anaerobic colony-forming units, black-pigmented Bacteroides, Fusobacterium and Actinobacillus actinomycetemcomitans in subgingival plaque). No significant differences in these variables existed between the 3 groups at baseline. The no-treatment (control) group showed no substantial clinical or microbiologic changes during the study. After 1 month, scaling and root planing had effected significant clinical improvement and significant shifts in the subgingival flora to a pattern more consistent with periodontal health; these changes were still evident at 3 months. In contrast, 1 month after metronidazole, there was some clinical improvement and a significant increase in cocci and a decrease in motile rods, but at 3 months these changes were no longer evident. The results show that the benefits of scaling and root planing are sustained for at least 3 months. However, the benefits of a single 2 g dose of metronidazole are both few and transient, indicating that this regimen, while effective against anaerobic infections in other organ systems, is not clinically or microbiologically effective in the treatment of adult periodontitis.

Adult↗
PubMed1986

Assessing the dental treatment needs of an adult Israeli military population.

The dental treatment needs of an adult population (career army personnel, Israeli Defence Forces, aged 20 to 46) were determined. A method is described for quantitating total restorative, endodontic, oral surgical, periodontal, and prosthetic treatment needs. The amount, and in some categories the complexity, of treatment required per person increased in proportion to age. The estimated time required per adult (all ages) to complete all dental treatments was approximately 10.5 h, including 1 h for dental hygiene therapy. These data permit calculation of cost and professional personnel needed to treat this population.

Adult↗
PubMed1986

Comparison of trends in the prevalence of caries and restorations in young adult populations of several countries.

We compared DMFT (decayed, missing and filled teeth) values of young adult populations (about 18- to 21 yr old) obtained over two decades in five industrialized countries (Denmark, Finland, Israel, Japan, U.S.A.). Trends of the active disease factor (D) and treatment factor (F) within and between these countries during two decades were also compared. No uniform trend in caries prevalence data, based on total DMFT scores, was found. In some countries DMFT scores declined (Denmark, U.S.A.), in some they remained relatively static (Finland), and in some they increased during the last 20 yr (Israel, Japan). However, DMFT scores did not always correlate with untreated lesions, D, which decreased remarkably in Denmark and Finland and moderately in the U.S.A., remained stable in Japan, but increased in Israel. Similarly, treatment of caries, F, varied in different countries, increasing dramatically in Finland and Japan and moderately in Israel, remaining static in Denmark, and decreasing in the U.S.A. These trends appear to be influenced largely by the extent of caries-preventive measures (particularly fluorides) in the respective countries, and to a lesser degree by sugar utilization and the availability of dental personnel. This age population has not been studied in a comparative fashion previously. This study also emphasizes the importance of looking not only at DMFT scores but at the trends in meeting treatment needs, D vs F scores.

Adolescent↗
PubMed1986

A theoretical study of in vivo lesion repair using a controlled-release device.

A theoretical model of lesion remineralization predicts that in vivo caries repair can be effected in a five-day period by means of a controlled- and sustained-release device containing calcium, phosphate, and fluoride. The calculations detail an 80% repair before the remineralization process stops. However, the fluoridated hydroxyapatite formed is calculated to be about 20% more resistant to future attack than is hydroxyapatite, making effective repair complete. Optimal flux (W) conditions for repair of 100 microns lesions are WCa = 1.0 X 10(-6) kg/m2s, stoichiometric phosphate, and WF = 2.0 X 10(-9) kg/m2s.

Adsorption↗
PubMed1985

The public's oral health and the dental research community--participant or observer?

Dental researchers may sometimes find themselves called upon to enter the public arena to promote or defend measures to improve the public's oral health. It is important, therefore, to keep up-to-date information at hand to supply to news media, public officials, and others, and to be aware of the opportunities and the pitfalls involved in communicating with the public.

Communication↗